Search Results - "Springer, Caroline J."

Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF by Heidorn, Sonja J., Milagre, Carla, Whittaker, Steven, Nourry, Arnaud, Niculescu-Duvas, Ion, Dhomen, Nathalie, Hussain, Jahan, Reis-Filho, Jorge S., Springer, Caroline J., Pritchard, Catrin, Marais, Richard

“…We describe a mechanism of tumorigenesis mediated by kinase-dead BRAF in the presence of oncogenic RAS. We show that drugs that selectively inhibit BRAF drive…”
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Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF by Wan, Paul T.C, Garnett, Mathew J, Roe, S.Mark, Lee, Sharlene, Niculescu-Duvaz, Dan, Good, Valerie M, Project, Cancer Genome, Jones, C.Michael, Marshall, Christopher J, Springer, Caroline J, Barford, David, Marais, Richard

“…Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kinase domain. Here we…”
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Primary melanoma of the CNS in children is driven by congenital expression of oncogenic NRAS in melanocytes by Pedersen, Malin, Küsters-Vandevelde, Heidi V N, Viros, Amaya, Groenen, Patricia J T A, Sanchez-Laorden, Berta, Gilhuis, Jacobus H, van Engen-van Grunsven, Ilse A, Renier, Willy, Schieving, Jolanda, Niculescu-Duvaz, Ion, Springer, Caroline J, Küsters, Benno, Wesseling, Pieter, Blokx, Willeke A M, Marais, Richard

“…NRAS mutations are common in human melanoma. To produce a mouse model of NRAS-driven melanoma, we expressed oncogenic NRAS (NRAS(G12D)) in mouse melanocytes…”
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Attenuated Salmonella Targets Prodrug Activating Enzyme Carboxypeptidase G2 to Mouse Melanoma and Human Breast and Colon Carcinomas for Effective Suicide Gene Therapy by FRIEDLOS, Frank, LEHOURITIS, Panos, OGILVIE, Lesley, MEDLEY, Douglas, DAVIES, Lawrence, BERMUDES, David, KING, Ivan, MARTIN, Jan, MARAIS, Richard, SPRINGER, Caroline J

“…Purpose: We engineered the oncolytic Salmonella typhimurium –derived bacterium VNP20009 as a vector to target delivery to tumors of the prodrug-activating…”
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Synthesis of Novel Cationic Lipids:  Effect of Structural Modification on the Efficiency of Gene Transfer by Heyes, James A, Niculescu-Duvaz, Dan, Cooper, Robert G, Springer, Caroline J

“…A series of novel cationic lipids was designed and synthesized in an effort to understand the importance of the various structural features with respect to…”
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A Phase I Study of Single Administration of Antibody-Directed Enzyme Prodrug Therapy with the Recombinant Anti–Carcinoembryonic Antigen Antibody-Enzyme Fusion Protein MFECP1 and a Bis-Iodo Phenol Mustard Prodrug by Mayer, Astrid, Francis, Roslyn J, Sharma, Surinder K, Tolner, Berend, Springer, Caroline J, Martin, Jan, Boxer, Geoff M, Bell, James, Green, Alan J, Hartley, John A, Cruickshank, Clare, Wren, Julie, Chester, Kerry A, Begent, Richard H J

“…Purpose: Antibody-directed enzyme prodrug therapy is a two-stage treatment whereby a tumor-targeted antibody-enzyme complex localizes in tumor for selective…”
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BRAF as a therapeutic target: a patent review (2006 - 2012) by Zambon, Alfonso, Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Marais, Richard, Springer, Caroline J

“…After its identification as an oncogene in 2002, mutant BRAF has become the target of a number of drug discovery programmes, primarily aimed at the treatment…”
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Investigating the Contribution of Collagen to the Tumor Biomechanical Phenotype with Noninvasive Magnetic Resonance Elastography by Li, Jin, Zormpas-Petridis, Konstantinos, Boult, Jessica K R, Reeves, Emma L, Heindl, Andreas, Vinci, Maria, Lopes, Filipa, Cummings, Craig, Springer, Caroline J, Chesler, Louis, Jones, Chris, Bamber, Jeffrey C, Yuan, Yinyin, Sinkus, Ralph, Jamin, Yann, Robinson, Simon P

“…Increased stiffness in the extracellular matrix (ECM) contributes to tumor progression and metastasis. Therefore, stromal modulating therapies and accompanying…”
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Small molecule inhibitors of BRAF in clinical trials by Zambon, Alfonso, Niculescu-Duvaz, Ion, Niculescu-Duvaz, Dan, Marais, Richard, Springer, Caroline J

“…Over the last few years, BRAF has emerged as a validated target in melanoma. This review summarises recent advances in the development of BRAF inhibitors,…”
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A Novel, Selective, and Efficacious Nanomolar Pyridopyrazinone Inhibitor of V600EBRAF by WHITTAKER, Steven, MENARD, Delphine, LAMBROS, Maryou, REIS-FILHO, Jorge S, MARAIS, Richard, SPRINGER, Caroline J, KIRK, Ruth, OGILVIE, Lesley, HEDLEY, Douglas, ZAMBON, Alfonso, LOPES, Filipa, PREECE, Natasha, MANNE, Helen, RANA, Sareena

“…Oncogenic BRAF is a critical driver of proliferation and survival and is thus a validated therapeutic target in cancer. We have developed a potent inhibitor,…”
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Hyperpolarized 13C magnetic resonance detection of carboxypeptidase G2 activity by Jamin, Yann, Gabellieri, Cristina, Smyth, Lynette, Reynolds, Steven, Robinson, Simon P., Springer, Caroline J., Leach, Martin O., Payne, Geoffrey S., Eykyn, Thomas R.

“…Carboxypeptidase G2 (CPG2) is a bacterial enzyme that is currently employed in a range of targeted cancer chemotherapy strategies such as gene‐directed enzyme…”
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Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma by Bridgeman, Victoria L, Wan, Elaine, Foo, Shane, Nathan, Mark R, Welti, Jonathan C, Frentzas, Sophia, Vermeulen, Peter B, Preece, Natasha, Springer, Caroline J, Powles, Thomas, Nathan, Paul D, Larkin, James, Gore, Martin, Vasudev, Naveen S, Reynolds, Andrew R

“…Sunitinib and pazopanib are antiangiogenic tyrosine kinase inhibitors (TKI) used to treat metastatic renal cell carcinoma (RCC). However, the ability of these…”
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Novel Fluorinated Prodrugs for Activation by Carboxypeptidase G2 Showing Good in Vivo Antitumor Activity in Gene-Directed Enzyme Prodrug Therapy by Davies, Lawrence C, Friedlos, Frank, Hedley, Douglas, Martin, Jan, Ogilvie, Lesley M, Scanlon, Ian J, Springer, Caroline J

“…Sixteen novel polyfluorinated benzoic acid mustards have been synthesized for use in gene-directed enzyme prodrug therapy (GDEPT). Eight of these were benzoic…”
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B-RAF is a therapeutic target in melanoma by KARASARIDES, Maria, CHILOECHES, Antonio, SPRINGER, Caroline J, MARAIS, Richard, HAYWARD, Robert, NICULESCU-DUVAZ, Dan, SCANLON, Ian, FRIEDLOS, Frank, OGILVIE, Lesley, HEDLEY, Douglas, MARTIN, Jan, MARSHALL, Christopher J

“…B-RAF is a serine/threonine-specific protein kinase that is mutated in approximately 70% of human melanomas. However, the role of this signalling molecule in…”
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Contrasting effects of sunitinib within in vivo models of metastasis by Welti, Jonathan C., Powles, Thomas, Foo, Shane, Gourlaouen, Morgane, Preece, Natasha, Foster, Julie, Frentzas, Sophia, Bird, Demelza, Sharpe, Kevin, van Weverwijk, Antoinette, Robertson, David, Soffe, Julie, Erler, Janine T., Pili, Roberto, Springer, Caroline J., Mather, Stephen J., Reynolds, Andrew R.

“…Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data…”
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Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents by Niculescu-Duvaz, Dan, Niculescu-Duvaz, Ion, Suijkerbuijk, Bart M.J.M., Ménard, Delphine, Zambon, Alfonso, Davies, Lawrence, Pons, Jean-Francois, Whittaker, Steven, Marais, Richard, Springer, Caroline J.

“…The RAS–RAF–MEK–ERK pathway is hyperactivated in 30% of human cancers. BRAF is a serine–threonine kinase, belonging to this pathway that is mutated with high…”
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Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2 by SCHEPELMANN, Silke, OGILVIE, Lesley M, HEDLEY, Douglas, FRIEDLOS, Frank, MARTIN, Janet, SCANLON, Ian, PING CHEN, MARAIS, Richard, SPRINGER, Caroline J

“…We have designed a targeted systemic suicide gene therapy that combines the advantages of tumor-selective gene expression, using the human telomerase promoter…”
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Detection of the Prodrug-Activating Enzyme Carboxypeptidase G2 Activity with Chemical Exchange Saturation Transfer Magnetic Resonance by Jamin, Yann, Eykyn, Thomas R., Poon, Evon, Springer, Caroline J., Robinson, Simon P.

“…Purpose The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using…”
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Selective activation of anticancer prodrugs by monoclonal antibody–enzyme conjugates by Senter, Peter D, Springer, Caroline J

“…A great deal of interest has surrounded the activities of monoclonal antibodies (mAbs), and mAb–drug, toxin and radionuclide conjugates for the treatment of…”
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Long Functionalized Poly(ethylene glycol)s of Defined Molecular Weight: Synthesis and Application in Solid-Phase Synthesis of Conjugates by Niculescu-Duvaz, Dan, Getaz, Jayne, Springer, Caroline J

“…A concise synthesis of long-chain poly(ethylene glycol) (PEG) of defined molecular weight up to 29 ethyleneoxy units is described. These PEG diols were…”
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