Search Results - "Spring, Alexander M."

Structural Impact of Single Ribonucleotide Residues in DNA by Evich, Marina, Spring-Connell, Alexander M., Storici, Francesca, Germann, Markus W.

“…Single ribonucleotide intrusions represent the most common nonstandard nucleotide type found incorporated in genomic DNA, yet little is known of their…”
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Combination Treatment with Sublethal Ionizing Radiation and the Proteasome Inhibitor, Bortezomib, Enhances Death-Receptor Mediated Apoptosis and Anti-Tumor Immune Attack by Cacan, Ercan, Spring, Alexander M, Kumari, Anita, Greer, Susanna F, Garnett-Benson, Charlie

“…Sub-lethal doses of radiation can modulate gene expression, making tumor cells more susceptible to T-cell-mediated immune attack. Proteasome inhibitors…”
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Recognition of Damaged DNA: Structure and Dynamic Markers by Germann, Markus W., Johnson, Christopher N., Spring, Alexander M.

“…DNA damage, a consequence of external factors and inherent metabolic processes, is omnipresent. Nature has devised multiple strategies to safeguard the genetic…”
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Evaluating the Validity of Risk Scoring in Predicting Pacemaker Rates following Transcatheter Aortic Valve Replacement by Yu, Pey-Jen, Koss, Elana, Rutkin, Bruce, Prasad, Vikram, Catalano, Michael A., Spring, Alexander M., Hartman, Alan

“…Introduction. Requirement of permanent pacemaker (PPM) implantation is a known and common postoperative consequence of transcatheter aortic valve replacement…”
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Nonproteolytic roles of 19S ATPases in transcription of CIITApIV genes by Maganti, Nagini, Moody, Tomika D, Truax, Agnieszka D, Thakkar, Meghna, Spring, Alexander M, Germann, Markus W, Greer, Susanna F

“…Accumulating evidence shows the 26S proteasome is involved in the regulation of gene expression. We and others have demonstrated that proteasome components…”
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Structural Basis of the RNase H1 Activity on Stereo Regular Borano Phosphonate DNA/RNA Hybrids by Johnson, Christopher N, Spring, Alexander M, Sergueev, Dimitri, Shaw, Barbara R, Germann, Markus W

“…Numerous DNA chemistries for improving oligodeoxynucleotide (ODN)-based RNA targeting have been explored. The majority of the modifications render the ODN/RNA…”
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Multifocal extracranial mycotic aneurysms in a patient with endocarditis by Spring, Alexander M., Catalano, Michael A., Farber, Bruce F., Krishnasastry, Kambhampaty V., Yu, Pey-Jen

“…This report describes the case of a 44-year-old man with Streptococcus gallolyticus (formerly S. bovis) endocarditis requiring surgical mitral valve…”
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Early Experience With Devices That Reduce Kidney Vascular Afterload From the Veins by SPRING, ALEXANDER M., MARSELA, ENKLAJD, JORDE, ULRICH P.

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Routine postdilation after 23 mm Sapien 3 Ultra implantation in the aortic position by Leone, Pier Pasquale, Sturla, Matteo, Spring, Alexander M., Echarte‐Morales, Julio, Scotti, Andrea, Ludwig, Sebastian, Coisne, Augustin, Slipczuk, Leandro, Assafin, Manaf, Chau, Mei, Ho, Edwin C., Granada, Juan F., Latib, Azeem

“…Background Residual transprosthetic gradient (TG) after transcatheter aortic valve replacement (TAVR) with balloon‐expandable valves (BEV) may be due to…”
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Racial and socioeconomic disparities in urgent transcatheter mitral valve repair: A National Inpatient Sample analysis by Spring, Alexander M., Catalano, Michael A., Rutkin, Bruce, Hartman, Alan, Yu, Pey‐Jen

“…Background Cardiac interventions performed urgently are known to be associated with poor outcomes compared with electively performed procedures. Transcatheter…”
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Prophylactic intra-aortic balloon pump in transfemoral transcatheter aortic valve implantation by Scotti, Andrea, Leone, Pier Pasquale, Sturla, Matteo, Curio, Jonathan, Spring, Alexander M, Ressa, Gaia, Ludwig, Sebastian, Sugiura, Tadahisa, Assafin, Manaf, Granada, Juan F, Chau, Mei, Doolittle, James, Latib, Azeem

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The Importance of Pre-Operative Imaging and 3-D Printing in Transcatheter Tricuspid Valve-in-Valve Replacement by Spring, Alexander M., Pirelli, Luigi, Basman, Craig L., Kliger, Chad A.

“…Pre-operative multimodality imaging has become an integral part of the planning and execution of transcatheter heart valve procedures. 3D printing of a…”
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Survival and readmission among patients with advanced cardiomyopathy undergoing transcatheter edge‐to‐edge mitral valve repair: Are we applying COAPT findings too broadly? by Catalano, Michael A., Delijani, David, Rutkin, Bruce, Spring, Alexander M., Hill, Matthew, Wilson, Sean, Kennedy, Kevin F., Hartman, Alan, Yu, Pey‐Jen

“…Objective Transcathether edge‐to‐edge mitral valve repair (TEER) has been shown to be an effective treatment for secondary mitral regurgitation (MR). However,…”
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NMR Structure Determination for Oligonucleotides by Spring-Connell, Alexander M, Evich, Marina, Germann, Markus W

“…NMR spectroscopy is a versatile tool for determining the structure and dynamics of nucleic acids under solution conditions. In this unit, we provide an…”
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Caffeine alters emotion and emotional responses in low habitual caffeine consumers by Giles, Grace E, Spring, Alexander M, Urry, Heather L, Moran, Joseph M, Mahoney, Caroline R, Kanarek, Robin B

“…Caffeine reliably increases emotional arousal, but it is unclear whether and how it influences other dimensions of emotion such as emotional valence. These…”
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E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction by De Lange, Willem J, Grimes, Adrian C, Hegge, Laura F, Spring, Alexander M, Brost, Taylor M, Ralphe, J Carter

“…Mutations in cardiac myosin binding protein C (cMyBP-C) are prevalent causes of hypertrophic cardiomyopathy (HCM). Although HCM-causing truncation mutations in…”
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DNA Sequence Context Conceals α-Anomeric Lesions by Johnson, Christopher N., Spring, Alexander M., Desai, Sunil, Cunningham, Richard P., Germann, Markus W.

“…DNA sequence context has long been known to modulate detection and repair of DNA damage. Recent studies using experimental and computational approaches have…”
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Supercooled aqueous nuclear magnetic resonance using agarose gels by Spring, Alexander M., Germann, Markus W.

“…Low-temperature nuclear magnetic resonance (NMR), especially under supercooled conditions, can give critical insight into biomolecular systems via slowed…”
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Heparin-induced thrombocytopenia in patients readmitted after open cardiac surgical procedures: A case series by Catalano, Michael A., Prasad, Vikram, Spring, Alexander M., Cassiere, Hugh, Chang, Tylis Y., Hartman, Alan, Yu, Pey-Jen

“…Heparin-induced thrombocytopenia (HIT) is an immune-mediated complication that occurs in a small percentage of patients exposed to heparin. Concerns of HIT are…”
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The importance of fitting in: conformational preference of selenium 2′ modifications in nucleosides and helical structures by Thompson, R. Adam, Spring, Alexander M., Sheng, Jia, Huang, Zhen, Germann, Markus W.

“…Selenomethionine incorporation has proven useful in X-ray crystallography of proteins to obtain phase information. In nucleic acids, the introduction of…”
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