Search Results - "Sprenger, Kayla G"

Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV by Conti, Simone, Ovchinnikov, Victor, Faris, Jonathan G, Chakraborty, Arup K, Karplus, Martin, Sprenger, Kayla G

“…The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system…”
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Common framework mutations impact antibody interfacial dynamics and flexibility by Rhodes, Emily R, Faris, Jonathan G, Petersen, Brian M, Sprenger, Kayla G

“…With the flood of engineered antibodies, there is a heightened need to elucidate the structural features of antibodies that contribute to specificity,…”
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Moving the needle: Employing deep reinforcement learning to push the boundaries of coarse-grained vaccine models by Faris, Jonathan G, Orbidan, Daniel, Wells, Charles, Petersen, Brenden K, Sprenger, Kayla G

“…Highly mutable infectious disease pathogens (hm-IDPs) such as HIV and influenza evolve faster than the human immune system can contain them, allowing them to…”
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Investigating how HIV-1 antiretrovirals differentially behave as substrates and inhibitors of P-glycoprotein via molecular dynamics simulations by Fuchs, Daisy I., Serio, Lauren D., Balaji, Sahana, Sprenger, Kayla G.

“…HIV-1 can rapidly infect the brain upon initial infection, establishing latent reservoirs that induce neuronal damage and/or death, resulting in HIV-Associated…”
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Regulatory Approved Monoclonal Antibodies Contain Framework Mutations Predicted From Human Antibody Repertoires by Petersen, Brian M, Ulmer, Sophia A, Rhodes, Emily R, Gutierrez-Gonzalez, Matias F, Dekosky, Brandon J, Sprenger, Kayla G, Whitehead, Timothy A

“…Monoclonal antibodies (mAbs) are an important class of therapeutics used to treat cancer, inflammation, and infectious diseases. Identifying highly developable…”
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Roadmap on biology in time varying environments by Murugan, Arvind, Husain, Kabir, Rust, Michael J, Hepler, Chelsea, Bass, Joseph, Pietsch, Julian M J, Swain, Peter S, Jena, Siddhartha G, Toettcher, Jared E, Chakraborty, Arup K, Sprenger, Kayla G, Mora, T, Walczak, A M, Rivoire, O, Wang, Shenshen, Wood, Kevin B, Skanata, Antun, Kussell, Edo, Ranganathan, Rama, Shih, Hong-Yan, Goldenfeld, Nigel

“…Biological organisms experience constantly changing environments, from sudden changes in physiology brought about by feeding, to the regular rising and setting…”
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Optimizing immunization protocols to elicit broadly neutralizing antibodies by Sprenger, Kayla G., Louveau, Joy E., Murugan, Pranav M., Chakraborty, Arup K.

“…Natural infections and vaccination with a pathogen typically stimulate the production of potent antibodies specific for the pathogen through a Darwinian…”
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Sequence–Structure–Binding Relationships Reveal Adhesion Behavior of the Car9 Solid-Binding Peptide: An Integrated Experimental and Simulation Study by Hellner, Brittney, Alamdari, Sarah, Pyles, Harley, Zhang, Shuai, Prakash, Arushi, Sprenger, Kayla G, De Yoreo, James J, Baker, David, Pfaendtner, Jim, Baneyx, François

“…Solid-binding peptides (SBPs) recognizing inorganic and synthetic interfaces have enabled a broad range of materials science applications and hold promise as…”
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One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening by Francino-Urdaniz, Irene M., Steiner, Paul J., Kirby, Monica B., Zhao, Fangzhu, Haas, Cyrus M., Barman, Shawn, Rhodes, Emily R., Leonard, Alison C., Peng, Linghang, Sprenger, Kayla G., Jardine, Joseph G., Whitehead, Timothy A.

“…The potential emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) escape mutants is a threat to the efficacy of existing…”
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Correction: Analysis of Poly(ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding mode by Linda Zhong-Johnson, En Ze, Dong, Ziyue, Canova, Christopher T., Destro, Francesco, Cañellas, Marina, Hoffman, Mikaila C., Maréchal, Jeanne, Johnson, Timothy M., Zheng, Maya, Schlau-Cohen, Gabriela S., Lucas, Maria Fátima, Braatz, Richard D., Sprenger, Kayla G., Voigt, Christopher A., Sinskey, Anthony J.

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Analysis of Poly(ethylene terephthalate) degradation kinetics of evolved IsPETase variants using a surface crowding model by Zhong-Johnson, En Ze Linda, Dong, Ziyue, Canova, Christopher T., Destro, Francesco, Cañellas, Marina, Hoffman, Mikaila C., Maréchal, Jeanne, Johnson, Timothy M., Zheng, Maya, Schlau-Cohen, Gabriela S., Lucas, Maria Fátima, Braatz, Richard D., Sprenger, Kayla G., Voigt, Christopher A., Sinskey, Anthony J.

“…Poly(ethylene terephthalate) (PET) is a major plastic polymer utilized in the single-use and textile industries. The discovery of PET-degrading enzymes…”
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Inhibition of the Exoglucanase Cel7A by a Douglas-Fir-Condensed Tannin by Oleson, Karl R, Sprenger, Kayla G, Pfaendtner, Jim, Schwartz, Daniel T

“…Douglas-fir forestry residues are a potential feedstock for saccharification-based biofuels, and condensed tannins are expected to make up ∼3% of the dry mass…”
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Determining dominant driving forces affecting controlled protein release from polymeric nanoparticles by Smith, Josh, Sprenger, Kayla G, Liao, Rick, Joseph, Andrea, Nance, Elizabeth, Pfaendtner, Jim

“…Enzymes play a critical role in many applications in biology and medicine as potential therapeutics. One specific area of interest is enzyme encapsulation in…”
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An in Silico Investigation into Polyester Adsorption onto Alumina toward an Improved Understanding of Hydrogenolysis Catalysts by Dong, Ziyue, Dunphy, Erin E, Wegner, Aidan B, Medlin, J Will, Toney, Michael F, Sprenger, Kayla G

“…Chemical recycling of end-of-life plastic wastes through hydrogenolysis is a promising pathway for achieving a circular plastics economy and reducing overall…”
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Multiscale affinity maturation simulations to elicit broadly neutralizing antibodies against HIV by Simone Conti, Victor Ovchinnikov, Jonathan G Faris, Arup K Chakraborty, Martin Karplus, Kayla G Sprenger

“…The design of vaccines against highly mutable pathogens, such as HIV and influenza, requires a detailed understanding of how the adaptive immune system…”
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Elucidating the role of carrier proteins in cytokine stabilization within double emulsion‐based polymeric nanoparticles by Rhodes, Emily R., Day, Nicole B., Aldrich, Emma C., Wyatt Shields, C., Sprenger, Kayla G.

“…Polymeric micro‐ and nanoparticles are useful vehicles for delivering cytokines to diseased tissues such as solid tumors. Double emulsion solvent evaporation…”
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Assessing cathode–electrolyte interphases in batteries by Xiao, Jie, Adelstein, Nicole, Bi, Yujing, Bian, Wenjuan, Cabana, Jordi, Cobb, Corie L., Cui, Yi, Dillon, Shen J., Doeff, Marca M., Islam, Saiful M., Leung, Kevin, Li, Mengya, Lin, Feng, Liu, Jun, Luo, Hongmei, Marschilok, Amy C., Meng, Ying Shirley, Qi, Yue, Sahore, Ritu, Sprenger, Kayla G., Tenent, Robert C., Toney, Michael F., Tong, Wei, Wan, Liwen F., Wang, Chongmin, Weitzner, Stephen E., Wu, Bingbin, Xu, Yaobin

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Development and Use of Molecular Simulation Tools to Study the Structure and Function of Biomolecules at Interfaces by Sprenger, Kayla G

“…Predicting and controlling the biophysical chemistry of protein/host interactions remains a pressing challenge of high fundamental interest across many…”
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