Search Results - "Spreen, Russell C"

A high throughput dried DMSO Log D lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection by Alelyunas, Yun W., Pelosi-Kilby, Luciana, Turcotte, Pascal, Kary, Mary-Britt, Spreen, Russell C.

“…A rapid throughput octanol–water lipophilicity measurement based on 96-well shake-flask and LC/UV/APPI/MS is described. The method utilizes central liquid…”
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Experimental solubility profiling of marketed CNS drugs, exploring solubility limit of CNS discovery candidate by Alelyunas, Yun W., Empfield, James R., McCarthy, Dennis, Spreen, Russell C., Bui, Khanh, Pelosi-Kilby, Luciana, Shen, Cindy

“…We determined the experimental solubility of CNS marketed drugs. Of the 98 drugs measured, greater than 90% had solubility >10 μM in pH 7.4 buffer. Only seven…”
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A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection by Alelyunas, Yun W., Pelosi-Kilby, Luciana, Turcotte, Pascal, Kary, Mary-Britt, Spreen, Russell C.

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Open access MS : A walk-up MS service by SPREEN, R. C, SCHAFFTER, L. M

“…A mass spectrometry system that is easy for nonspectrometrists to use can provide data that improve efficiency and productivity. Russell and Schaffter discuss…”
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Effects of site-specific acetylation on .omega.-conotoxin GVIA binding and function by Lampe, Richard A, Lo, Mathew M. S, Keith, Richard A, Horn, Michael B, McLane, Michael W, Herman, Joseph L, Spreen, Russell C

“…Chemical modification of omega-conotoxin GVIA (omega-CgTXGVIA) was performed using nonsaturating concentrations of acetic anhydride to generate seven distinct…”
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Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly by SCOTT, C. W, SPREEN, R. C, HERMAN, J. L, CHOW, F. P, DAVISON, M. D, YOUNG, J, CAPUTO, C. B

“…Tau protein is an integral component of paired helical filaments, a pathological feature of Alzheimer's disease. tau extracted from these filaments displays…”
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Peer Reviewed: Open Access MS: A Walk-up MS Service by SPREEN, Russell C., SCHAFFTER, Lisa M.

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Casein kinase II preferentially phosphorylates human tau isoforms containing an amino-terminal insert. Identification of threonine 39 as the primary phosphate acceptor by GREENWOOD, J. A, SCOTT, C. W, SPREEN, R. C, CAPUTO, C. B, JOHNSON, G. V. W

“…The in vitro phosphorylation of the microtubule-associated protein tau by casein kinase II was studied. Purified human brain tau was phosphorylated by casein…”
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Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses by Lampe, R A, Defeo, P A, Davison, M D, Young, J, Herman, J L, Spreen, R C, Horn, M B, Mangano, T J, Keith, R A

“…omega-Grammotoxin SIA, a peptidergic blocker of voltage-sensitive calcium channel (VSCC) responses, was purified from Grammostola spatulata (tarantula spider)…”
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A high throughput dried DMSO LogD lipophilicity measurement based on 96-well shake-flask and atmospheric pressure photoionization mass spectrometry detection by Alelyunas, Yun W, Pelosi-Kilby, Luciana, Turcotte, Pascal, Kary, Mary-Britt, Spreen, Russell C

“…A rapid throughput octanol-water lipophilicity measurement based on 96-well shake-flask and LC/UV/APPI/MS is described. The method utilizes central liquid…”
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Peer Reviewed: Open Access MS: A Walk-up MS Service: An MS system that is easy for nonspectrometrists to use can provide data that improve efficiency and productivity by Spreen, Russell C, Schaffter, Lisa M

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The influence of amino acid sequence on the fibrillogenicity and amyloidogenicity of the carboxy-terminus of beta-amyloid precursor protein by Caputo, C B, Sobel, I R, Sygowski, L A, Lampe, R A, Spreen, R C

“…C-APP, a synthetic peptide corresponding to the C-terminal 20 amino acids of beta-amyloid precursor protein, forms amyloid fibrils in vitro. We investigated…”
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