Search Results - "Spray, D"

P2X7 receptor-Pannexin1 complex: pharmacology and signaling by Iglesias, R, Locovei, S, Roque, A, Alberto, A P, Dahl, G, Spray, D C, Scemes, E

“…Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7) receptor (P2X(7)R)…”
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Severe COVID-19 and healthcare-associated infections on the ICU: time to remember the basics? by Sturdy, A., Basarab, M., Cotter, M., Hager, K., Shakespeare, D., Shah, N., Randall, P., Spray, D., Arnold, A.

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Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes by He, Z, Leong, D.J, Zhuo, Z, Majeska, R.J, Cardoso, L, Spray, D.C, Goldring, M.B, Cobelli, N.J, Sun, H.B

“…Summary Objective To determine the strain-induced signaling pathways involved in regulating the transactivation of the transcription regulator Cbp/p300…”
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Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy by Friedman, L. K., Mancuso, J., Patel, A., Kudur, V., Leheste, J. R., Iacobas, S., Botta, J., Iacobas, D. A., Spray, D. C.

“…Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained…”
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The connexin43-dependent transcriptome during brain development: Importance of genetic background by Iacobas, S, Iacobas, D.A, Spray, D.C, Scemes, E

“…Abstract Use of null mutant mice is a powerful way to evaluate the role of specific proteins in brain function. Studies performed on knockout mice have…”
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How to close a gap junction channel. Efficacies and potencies of uncoupling agents by Rozental, R, Srinivas, M, Spray, D C

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The role of aquaporin-4 in the blood–brain barrier development and integrity: Studies in animal and cell culture models by Nicchia, G.P., Nico, B., Camassa, L.M.A., Mola, M.G., Loh, N., Dermietzel, R., Spray, D.C., Svelto, M., Frigeri, A.

“…Aquaporin-4 (AQP4) is the major water channel expressed in brain perivascular astrocyte processes. Although the role of AQP4 in brain edema has been…”
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Mechanisms of glutamate release from astrocytes: gap junction “hemichannels”, purinergic receptors and exocytotic release by Parpura, Vladimir, Scemes, Eliana, Spray, David C

“…Neuronal exocytotic release of glutamate at synapses involves a highly specialized vesicular apparatus, consisting of a variety of proteins connected to the…”
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Quinine Blocks Specific Gap Junction Channel Subtypes by Srinivas, Miduturu, Hopperstad, Matthew G., Spray, David C.

“…We demonstrate that the antimalarial drug quinine specifically reduces currents through gap junctions formed by some connexins (Cx) in transfected mammalian…”
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Gap junctions remain open during cytochrome c-induced cell death: relationship of conductance to 'bystander' cell killing by Cusato, K, Ripps, H, Zakevicius, J, Spray, D C

“…Previous reports have shown that gap junctions relay cell death in many cell types. However, changes in electrical coupling and their dynamics during cell…”
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Human and mouse microglia express connexin36, and functional gap junctions are formed between rodent microglia and neurons by Dobrenis, K., Chang, H.-Y., Pina-Benabou, M.H., Woodroffe, A., Lee, S.C., Rozental, R., Spray, D.C., Scemes, E.

“…Microglia, the tissue macrophages of the central nervous system (CNS), intimately interact with neurons physically and through soluble factors that can affect…”
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Sex-dependent gene regulatory networks of the heart rhythm by Iacobas, D. A., Iacobas, S., Thomas, N., Spray, D. C.

“…Expression level, control, and intercoordination of 66 selected heart rhythm determinant (HRD) genes were compared in atria and ventricles of four male and…”
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Gap junctions in the brain: where, what type, how many and why? by Dermietzel, R, Spray, D C

“…Gap junctions represent well-documented means of intercellular communication in various tissues, including the brain, where they function as portals allowing…”
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Molecular and Functional Diversity of Neural Connexins in the Retina by Dermietzel, R, Kremer, M, Paputsoglu, G, Stang, A, Skerrett, I. M, Gomes, D, Srinivas, M, Janssen-Bienhold, U, Weiler, R, Nicholson, B. J, Bruzzone, R, Spray, D. C

“…Electrical synapses (gap junctions) in neuronal circuits have become a major focus in the study of network properties such as synchronization and oscillation…”
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Hypertension in connexin40-null mice: a renin disorder by Spray, D.C.

“…Studies described in this issue indicate that the gap junction protein connexin40 (Cx40) appears to play an unexpected role in blood pressure regulation. In…”
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Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro by Elshami, A A, Saavedra, A, Zhang, H, Kucharczuk, J C, Spray, D C, Fishman, G I, Amin, K M, Kaiser, L R, Albelda, S M

“…Tumor cells transduced with the herpes simplex virus thymidine kinase (HSVtk) gene are sensitive to the anti-viral drug ganciclovir (GCV). However, nearby…”
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Gap junctions: new tools, new answers, new questions by Bennett, M V, Barrio, L C, Bargiello, T A, Spray, D C, Hertzberg, E, Sáez, J C

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Gap Junctions in Vascular Tissues: Evaluating the Role of Intercellular Communication in the Modulation of Vasomotor Tone by Christ, George J, Spray, David C, El-Sabban, Marwan, Moore, Lisa K, Brink, Peter R

“…Integration and coordination of responses among vascular wall cells are critical to the local modulation of vasomotor tone and to the maintenance of…”
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Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis by Dermietzel, R, Hertberg, EL, Kessler, JA, Spray, DC

“…The properties of astroglial gap junction channels and the protein that constitutes the channels were characterized by immunocytochemical, molecular…”
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Reciprocal Regulation of the Junctional Proteins Claudin-1 and Connexin43 by Interleukin-1beta in Primary Human Fetal Astrocytes by Duffy, Heather S, John, Gareth R, Lee, Sunhee C, Brosnan, Celia F, Spray, David C

“…Vertebrate tissues use multiple junctional types to establish and maintain tissue architecture, including gap junctions for cytoplasmic connectivity and tight…”
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