Search Results - "Spratt, Kaye"

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV by Tebas, Pablo, Stein, David, Tang, Winson W, Frank, Ian, Wang, Shelley Q, Lee, Gary, Spratt, S. Kaye, Surosky, Richard T, Giedlin, Martin A, Nichol, Geoff, Holmes, Michael C, Gregory, Philip D, Ando, Dale G, Kalos, Michael, Collman, Ronald G, Binder-Scholl, Gwendolyn, Plesa, Gabriela, Hwang, Wei-Ting, Levine, Bruce L, June, Carl H

“…In this small study, investigators genetically disrupted the HIV receptor CCR5 in CD4 T cells of aviremic persons who were infected with HIV. After reinfusion…”
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Delayed administration of a bio-engineered zinc-finger VEGF-A gene therapy is neuroprotective and attenuates allodynia following traumatic spinal cord injury by Figley, Sarah A, Liu, Yang, Karadimas, Spyridon K, Satkunendrarajah, Kajana, Fettes, Peter, Spratt, S Kaye, Lee, Gary, Ando, Dale, Surosky, Richard, Giedlin, Martin, Fehlings, Michael G

“…Following spinal cord injury (SCI) there are drastic changes that occur in the spinal microvasculature, including ischemia, hemorrhage, endothelial cell death…”
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An engineered transcription factor which activates VEGF-A enhances recovery after spinal cord injury by Liu, Yang, Figley, Sarah, Spratt, S. Kaye, Lee, Gary, Ando, Dale, Surosky, Richard, Fehlings, Michael G

“…Abstract Spinal cord injury (SCI) leads to local vascular disruption and progressive ischemia, which contribute to secondary degeneration. Enhancing…”
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Treatment of traumatic brain injury using zinc-finger protein gene therapy targeting VEGF-A by Siddiq, Ishita, Park, Eugene, Liu, Elaine, Spratt, S Kaye, Surosky, Richard, Lee, Gary, Ando, Dale, Giedlin, Marty, Hare, Gregory M T, Fehlings, Michael G, Baker, Andrew J

“…Vascular endothelial growth factor (VEGF) plays a role in angiogenesis and has been shown to be neuroprotective following central nervous system trauma. In the…”
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Induction of angiogenesis in a mouse model using engineered transcription factors by Giordano, Frank J, Rebar, Edward J, Huang, Yan, Hickey, Reed, Nath, Anjali K, Meoli, David, Nath, Sameer, Chen, Bingliang, Xu, Lei, Liang, Yuxin, Jamieson, Andrew C, Zhang, Lei, Spratt, S Kaye, Case, Casey C, Wolffe, Alan

“…The relationship between the structure of zinc-finger protein (ZFP) transcription factors and DNA sequence binding specificity has been extensively studied…”
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A Designed Zinc-finger Transcriptional Repressor of Phospholamban Improves Function of the Failing Heart by Zhang, H Steve, Liu, Dingang, Huang, Yan, Schmidt, Stefan, Hickey, Reed, Guschin, Dmitry, Su, Haili, Jovin, Ion S, Kunis, Mike, Hinkley, Sarah, Liang, Yuxin, Hinh, Linda, Spratt, S Kaye, Case, Casey C, Rebar, Edward J, Ehrlich, Barbara, Gregory, Philip D, Giordano, Frank J

“…Selective inhibition of disease-related proteins underpins the majority of successful drug–target interactions. However, development of effective antagonists…”
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Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy by PRICE, Sally A, DENT, Carolyn, TOMLINSON, David R, DURAN-JIMENEZ, Beatriz, YUXIN LIANG, LEI ZHANG, REBAR, Edward J, CASE, Casey C, GREGORY, Philip D, MARTIN, Tyler J, KAYE SPRATT, S

“…Gene Transfer of an Engineered Transcription Factor Promoting Expression of VEGF-A Protects Against Experimental Diabetic Neuropathy Sally A. Price 1 , Carolyn…”
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Zinc-Finger Protein-Targeted Gene Regulation: Genomewide Single-Gene Specificity by Tan, Siyuan, Guschin, Dmitry, Davalos, Albert, Lee, Ya-Li, Snowden, Andrew W., Jouvenot, Yann, Zhang, H. Steven, Howes, Katherine, McNamara, Andrew R., Lai, Albert, Ullman, Chris, Reynolds, Lindsey, Moore, Michael, Isalan, Mark, Berg, Lutz-Peter, Campos, Bradley, Qi, Hong, Spratt, S. Kaye, Case, Casey C., Pabo, Carl O., Campisi, Judith, Gregory, Philip D.

“…Zinc-finger protein transcription factors (ZFP TFs) can be designed to control the expression of any desired target gene, and thus provide potential…”
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Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes by PAWSON, Elizabeth J, DURAN-JIMENEZ, Beatriz, SUROSKY, Richard, BROOKE, Heather E, SPRATT, S. Kaye, TOMLINSON, David R, GARDINER, Natalie J

“…Engineered Zinc Finger Protein–Mediated VEGF-A Activation Restores Deficient VEGF-A in Sensory Neurons in Experimental Diabetes Elizabeth J. Pawson 1 , Beatriz…”
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ZFN-Mediated Gene Targeting at the Albumin Locus in Liver Results in Therapeutic Levels of Human FIX in Mice and Non-Human Primates by Wechsler, Thomas, Meyer, Kathleen E., Spratt, S. Kaye, Greengard, Judith, Santiago, Yolanda, Sproul, Scott, Surosky, Richard, Paschon, David E., Dubois-Stringfellow, Nathalie, Ando, Dale Genji, Nichol, Geoff, Rebar, Edward J., Holmes, Michael C.

“…Hemophilia is an attractive target for gene therapy, since activity levels as low as 1% to 2% of normal are beneficial and levels of ~5% prevent spontaneous…”
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Efficient clinical scale gene modification via zinc finger nuclease-targeted disruption of the HIV co-receptor CCR5 by Maier, Dawn A, Brennan, Andrea L, Jiang, Shuguang, Binder-Scholl, Gwendolyn K, Lee, Gary, Plesa, Gabriela, Zheng, Zhaohui, Cotte, Julio, Carpenito, Carmine, Wood, Travis, Spratt, S Kaye, Ando, Dale, Gregory, Philip, Holmes, Michael C, Perez, Elena E, Riley, James L, Carroll, Richard G, June, Carl H, Levine, Bruce L

“…Since HIV requires CD4 and a co-receptor, most commonly C-C chemokine receptor 5 (CCR5), for cellular entry, targeting CCR5 expression is an attractive…”
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Persistent and therapeutic concentrations of human factor IX in mice after hepatic gene transfer of recombinant AAV vectors by Snyder, Richard O, Miao, Carol H, Patijn, Gijsbert A, Spratt, S. Kaye, Danos, Olivier, Nagy, Dea, Gown, Allen M, Winther, Brian, Meuse, Leonard, Cohen, Lawrence K, Thompson, Arthur R, Kay, Mark A

“…Haemophilia B, or factor IX deficiency, is a X-linked recessive disorder that occurs in about one in 25,000 males, and severely affected people are at risk for…”
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Prolonged Production of NADPH Oxidase-Corrected Granulocytes after Gene Therapy of Chronic Granulomatous Disease by Malech, H L, Maples, P B, Whiting-Theobald, N, Linton, G F, Sekhsaria, S, Vowells, S J, Li, F, Miller, J A, DeCarlo, E, Holland, S M, Leitman, S F, Carter, C S, Butz, R E, Read, E J, Fleisher, T A, Schneiderman, R D, Van Epps, D E, Spratt, S K, Maack, C A, Rokovich, J A, Cohen, L K, Gallin, J I

“…Little is known about the potential for engraftment of autologous hematopoietic stem cells in human adults not subjected to myeloablative conditioning…”
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Efficient and stable adeno-associated virus-mediated transduction in the skeletal muscle of adult immunocompetent mice by Snyder, R O, Spratt, S K, Lagarde, C, Bohl, D, Kaspar, B, Sloan, B, Cohen, L K, Danos, O

“…Recombinant adeno-associated virus (rAAV) vectors were evaluated for gene transfer into the skeletal muscle of adult immunocompetent mice. A study using a…”
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Ocular Gene Transfer with Self-Complementary AAV Vectors by Yokoi, Katsutoshi, Kachi, Shu, Zhang, H. Steve, Gregory, Philip D, Spratt, S. Kaye, Samulski, R. Jude, Campochiaro, Peter A

“…Self-complementary AAV (scAAV) vectors have been developed to circumvent rate-limiting second-strand synthesis in single-stranded AAV vector genomes and to…”
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Gene therapy for traumatic central nervous system injury and stroke using an engineered zinc finger protein that upregulates VEGF-A by D'Onofrio, Philippe M, Thayapararajah, Mahinthan, Lysko, Meghan D, Magharious, Mark, Spratt, S Kaye, Lee, Gary, Ando, Dale, Surosky, Richard, Fehlings, Michael G, Koeberle, Paulo D

“…Recent studies have identified anti-apoptotic functions for vascular endothelial growth factor (VEGF) in the central nervous system (CNS). However, VEGF…”
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Selective uptake and sustained expression of AAV vectors following subcutaneous delivery by Donahue, Brian A., McArthur, James G., Spratt, S. Kaye, Bohl, Delphine, Lagarde, Catherine, Sanchez, Lisa, Kaspar, Brian A., Sloan, Barbara A., Lee, Ya Li, Danos, Olivier, Snyder, Richard O.

“…Background Recombinant adeno‐associated viral (rAAV) vectors are capable of long‐term expression of secreted and intracellular proteins following delivery to…”
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Isolation and characterization of the human pulmonary surfactant apoprotein gene by White, R. Tyler, Damm, Deborah, Miller, Judith, Spratt, Kaye, Schilling, James, Hawgood, Samuel, Benson, Brad, Cordell, Barbara

“…Pulmonary surfactant is a phospholipid-protein complex which serves to lower the surface tension at the air-liquid interface in the alveoli of the mammalian…”
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Combination dosing of CLN1 gene therapy extends lifespan in a mouse model of infantile neuronal ceroid lipofuscinosis by Rozenberg, Alejandra J., Lykken, Erik, Spratt, Kaye, Miller, Timothy J., Gray, Steven J.

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Intravenous administration of CLN3 gene therapy for juvenile neuronal ceroid lipofuscinosis by Kerns, Scott, Daum, J., Bosch, M., Fallet, R., Odvody, J., Henson, Kari, Spratt, Kaye, Kielian, Tammy

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