Search Results - "Spratley, Samantha J."

The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure by Hill, Chris H., Cook, Georgia M., Spratley, Samantha J., Fawke, Stuart, Graham, Stephen C., Deane, Janet E.

“…Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient…”
Get full text

A simeprevir-inducible molecular switch for the control of cell and gene therapies by Chin, Stacey E., Schindler, Christina, Vinall, Lisa, Dodd, Roger B., Bamber, Lisa, Legg, Sandrine, Sigurdardottir, Anna, Rees, D. Gareth, Malcolm, Tim I. M., Spratley, Samantha J., Granéli, Cecilia, Sumner, Jonathan, Tigue, Natalie J.

“…Chemical inducer of dimerization (CID) modules can be used effectively as molecular switches to control biological processes, and thus there is significant…”
Get full text

Protein Kinase D Regulates Cofilin Activity through p21-activated Kinase 4 by Spratley, Samantha J., Bastea, Ligia I., Döppler, Heike, Mizuno, Kensaku, Storz, Peter

“…Dynamic reorganization of the actin cytoskeleton at the leading edge is required for directed cell migration. Cofilin, a small actin-binding protein with…”
Get full text

Protein kinase d isoforms differentially modulate cofilin-driven directed cell migration by Döppler, Heike, Bastea, Ligia I, Borges, Sahra, Spratley, Samantha J, Pearce, Sarah E, Storz, Peter

“…Protein kinase D (PKD) enzymes regulate cofilin-driven actin reorganization and directed cell migration through both p21-activated kinase 4 (PAK4) and the…”
Get full text

Protein kinase D-mediated phosphorylation at Ser99 regulates localization of p21-activated kinase 4 by Bastea, Ligia I, Döppler, Heike, Pearce, Sarah E, Durand, Nisha, Spratley, Samantha J, Storz, Peter

“…PAKs (p21-activated kinases) are effectors of RhoGTPases. PAK4 contributes to regulation of cofilin at the leading edge of migrating cells through activation…”
Get more information

A Tetrameric Assembly of Saposin A: Increasing Structural Diversity in Lipid Transfer Proteins by Shamin, Maria, Spratley, Samantha J., Graham  , Stephen C., Deane , Janet E.

“…Saposins are lipid transfer proteins required for the degradation of sphingolipids in the lysosome. These small proteins bind lipids by transitioning from a…”
Get full text

New therapeutic approaches for Krabbe disease: The potential of pharmacological chaperones by Spratley, Samantha J., Deane, Janet E.

“…Missense mutations in the lysosomal hydrolase β‐galactocerebrosidase (GALC) account for at least 40% of known cases of Krabbe disease (KD). Most of these…”
Get full text

Molecular Mechanisms of Disease Pathogenesis Differ in Krabbe Disease Variants by Spratley, Samantha J., Hill, Chris H., Viuff, Agnete H., Edgar, James R., Skjødt, Karsten, Deane, Janet E.

“…Krabbe disease is a devastating neurodegenerative disorder caused by defects in the lysosomal hydrolase galactocerebrosidase (GALC). Over 100 different…”
Get full text

Azasugar inhibitors as pharmacological chaperones for Krabbe disease by Hill, Chris H, Viuff, Agnete H, Spratley, Samantha J, Salamone, Stéphane, Christensen, Stig H, Read, Randy J, Moriarty, Nigel W, Jensen, Henrik H, Deane, Janet E

“…Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the…”
Get full text

Abstract 2364: Regulation of cofilin activity and tumor cell migration through protein kinase D by Spratley, Samantha J., Storz, Peter

“…Abstract During early metastatic events in cancer, reorganization of the actin cytoskeleton must occur to allow for cell invasion and migration. A key enzyme…”
Get full text

Azasugar inhibitors as pharmacological chaperones for Krabbe diseaseElectronic supplementary information (ESI) available: Details of IGF, AGF, IGL and DIL syntheses including NMR spectra. Table containing X-ray data collection and refinement statistics. Dose dependence of thermal stabilization of GALC. Controls for DSF assays. IGF- and AGF-mediated stabilization of GALC is buffer and pH dependent. See DOI: 10.1039/c5sc00754bData deposition: the atomic coordinates and structure factors have been by Hill, Chris H, Viuff, Agnete H, Spratley, Samantha J, Salamone, Stéphane, Christensen, Stig H, Read, Randy J, Moriarty, Nigel W, Jensen, Henrik H, Deane, Janet E

“…Krabbe disease is a devastating neurodegenerative disorder characterized by rapid demyelination of nerve fibers. This disease is caused by defects in the…”
Get full text

Azasugar inhibitors as pharmacological chaperones for Krabbe disease† †Electronic supplementary information (ESI) available: Details of IGF, AGF, IGL and DIL syntheses including NMR spectra. Table containing X-ray data collection and refinement statistics. Dose dependence of thermal stabilization of GALC. Controls for DSF assays. IGF- and AGF-mediated stabilization of GALC is buffer and pH dependent. See DOI: 10.1039/c5sc00754b Click here for additional data file. ‡ ‡Data deposition: the atomic by Hill, Chris H., Viuff, Agnete H., Spratley, Samantha J., Salamone, Stéphane, Christensen, Stig H., Read, Randy J., Moriarty, Nigel W., Jensen, Henrik H., Deane, Janet E.

“…Modified azasugar molecules have been synthesized and characterized as excellent pharmacological chaperone candidates to treat the neurodegenerative disorder…”
Get full text