Search Results - "Sprague, Daniel J"

Mu-opioid receptor selective superagonists produce prolonged respiratory depression by Malcolm, Nicholas J., Palkovic, Barbara, Sprague, Daniel J., Calkins, Maggie M., Lanham, Janelle K., Halberstadt, Adam L., Stucke, Astrid G., McCorvy, John D.

“…Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor…”
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Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin by AbuEid, Mahmoud, Keyes, Robert F., McAllister, Donna, Peterson, Francis, Kadamberi, Ishaque Pulikkal, Sprague, Daniel J., Chaluvally-Raghavan, Pradeep, Smith, Brian C., Dwinell, Michael B.

“…Triphenylphosphonium (TPP+) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date,…”
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Enantio- and periselective nitroalkene Diels-Alder reaction by Narcis, Maurice J, Sprague, Daniel J, Captain, Burjor, Takenaka, Norito

“…The periselective Diels-Alder reaction of 5-substituted pentamethylcyclopentadienes and nitroethylene has been realized by helical-chiral hydrogen bond donor…”
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Adaptation of a Small-Molecule Hydrogen-Bond Donor Catalyst to an Enantioselective Hetero-Diels–Alder Reaction Hypothesized for Brevianamide Biosynthesis by Sprague, Daniel J, Nugent, Benjamin M, Yoder, Ryan A, Vara, Brandon A, Johnston, Jeffrey N

“…Chiral diamine-derived hydrogen-bond donors were evaluated for their ability to effect stereocontrol in an intramolecular hetero-Diels–Alder (HDA) reaction…”
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Count on It! Accurately Measured Respiratory Rate Is Associated with Lung Function and Clinical Severity in Children with Acute Asthma Exacerbations by Arnold, Donald H., MD, MPH, Penrod, Cody H., MD, Sprague, Daniel J., BS, Hartert, Tina V., MD, MPH

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Identification of a dihydropyridine scaffold that blocks ryanodine receptors by Gunaratne, Gihan S., Rebbeck, Robyn T., McGurran, Lindsey M., Yan, Yasheng, Arzua, Thiago, Frolkis, Talia, Sprague, Daniel J., Bai, Xiaowen, Cornea, Razvan L., Walseth, Timothy F., Marchant, Jonathan S.

“…Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca2+ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in…”
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Substituted Imidazoline Synthesis: A Diastereo- and Enantioselective aza-Henry Route to a Human Proteasome Modulator by Sprague, Daniel J, Johnston, Jeffrey N

“…The first enantio- and diastereoselective synthesis of Tepe’s human proteasome modulator is described. Routes to this and other highly substituted chiral…”
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Diastereo- and enantioselective additions of α-nitro esters to imines for anti -α,β-diamino acid synthesis with α-alkyl-substitution by Sprague, Daniel J, Singh, Anand, Johnston, Jeffrey N

“…The discovery that a -symmetric bis(AMidine) [BAM] catalyst promotes an -selective addition of α-substituted α-nitro esters to imines is described, providing…”
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Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity by Rohr, Claudia M, Sprague, Daniel J, Park, Sang-Kyu, Malcolm, Nicholas J, Marchant, Jonathan S

“…The drug praziquantel (PZQ) is the key clinical therapy for treating schistosomiasis and other infections caused by parasitic flatworms. A schistosome target…”
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The anthelmintic meclonazepam activates a schistosome transient receptor potential channel by Park, Sang-Kyu, Sprague, Daniel J, Rohr, Claudia M, Chulkov, Evgeny G, Petrow, Ian, Kumar, Sushil, Marchant, Jonathan S

“…Parasitic flatworms cause various clinical and veterinary infections that impart a huge burden worldwide. The most clinically impactful infection is…”
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Molecular and cellular basis of praziquantel action in the cardiovascular system by Yahya, Nawal A, Lanham, Janelle K, Sprague, Daniel J, Palygin, Oleg, McCorvy, John D, Marchant, Jonathan S

“…The anthelmintic drug praziquantel (PZQ) causes contraction of parasitic schistosomes as well as constriction of blood vessels within the mesenteric…”
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Target-based discovery of a broad-spectrum flukicide by Sprague, Daniel J., Park, Sang-Kyu, Gramberg, Svenja, Bauer, Lisa, Rohr, Claudia M., Chulkov, Evgeny G., Smith, Emery, Scampavia, Louis, Spicer, Timothy P., Haeberlein, Simone, Marchant, Jonathan S.

“…Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases—for example, the parasitic blood fluke…”
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Covalent-Fragment Screening of BRD4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites by Olp, Michael D, Sprague, Daniel J, Goetz, Christopher J, Kathman, Stefan G, Wynia-Smith, Sarah L, Shishodia, Shifali, Summers, Steven B, Xu, Ziyang, Statsyuk, Alexander V, Smith, Brian C

“…BRD4, a member of the bromodomain and extraterminal domain (BET) family, has emerged as a promising epigenetic target in cancer and inflammatory disorders. All…”
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The TRIM33 Bromodomain Recognizes Histone Lysine Lactylation by Nuñez, Raymundo, Sidlowski, Paul F. W., Steen, Erica A., Wynia-Smith, Sarah L., Sprague, Daniel J., Keyes, Robert F., Smith, Brian C.

“…Histone lysine lactylation (Kla) regulates inflammatory gene expression in activated macrophages and mediates the polarization of inflammatory (M1) to…”
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Development of activity-based probes for the protein deacylase Sirt1 by Goetz, Christopher J., Sprague, Daniel J., Smith, Brian C.

“…[Display omitted] •Development of a Sirt1-selective activity-based probe (ABP).•Activity-based labeling measured Sirt1 activity in vitro and in HEK293T…”
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Zinc‐Chelating BET Bromodomain Inhibitors Selectively Accumulate and Affect Gene Expression in Pancreatic β‐Cells by Jones Lipinski, Rachel A., Stancill, Jennifer S., Wynia‐Smith, Sarah L., Sprague, Daniel J., Nunez, Raymundo, Bird, Amir, Corbett, John A., Smith, Brian C.

“…The islets of Langerhans are a heterogeneous mixture of endocrine (hormone‐secreting) cells in the mammalian pancreas. Of particular interest are the β‐cells…”
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TRP drop, TRP drop: a steady patter of anti-schistosomal target illumination by Sprague, Daniel J., Rohr, Claudia M., Marchant, Jonathan S.

“…Infections caused by parasitic flatworms impart a significant disease burden. This is well exemplified by the neglected tropical disease schistosomiasis, which…”
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The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure-Activity Relationships at TRPM PZQ Orthologs by Sprague, Daniel J, Kaethner, Marc, Park, Sang-Kyu, Rohr, Claudia M, Harris, Jade L, Maillard, David, Spangenberg, Thomas, Lundström-Stadelmann, Britta, Marchant, Jonathan S

“…The anthelmintic drug praziquantel remains a key clinical therapy for treating various diseases caused by parasitic flatworms. The parasite target of…”
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The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure-Activity Relationships at TRPMPZQ Orthologs by Sprague, Daniel J, Kaethner, Marc, Park, Sang-Kyu, Rohr, Claudia M, Harris, Jade L, Maillard, David, Spangenberg, Thomas, Lundström-Stadelmann, Britta, Marchant, Jonathan S

“…The anthelmintic drug praziquantel remains a key clinical therapy for treating various diseases caused by parasitic flatworms. The parasite target of…”
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Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12 by Sprague, Daniel J., Getschman, Anthony E., Fenske, Tyler G., Volkman, Brian F., Smith, Brian C.

“…CXCL12, a CXC-type chemokine, binds its receptor CXCR4, and the resulting signaling cascade is essential during development and subsequently in immune…”
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