Search Results - "Spracklen, Cassandra"

Maternal Hyperlipidemia and the Risk of Preeclampsia: A Meta-Analysis by SPRACKLEN, Cassandra N, SMITH, Caitlin J, SAFTLAS, Audrey F, ROBINSON, Jennifer G, RYCKMAN, Kelli K

“…Published reports examining lipid levels during pregnancy and preeclampsia have been inconsistent. The objective of this meta-analysis was to test the…”
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Progress in Defining the Genetic Contribution to Type 2 Diabetes in Individuals of East Asian Ancestry by Spracklen, Cassandra N., Sim, Xueling

“…Purpose of Review Prevalence of type 2 diabetes (T2D) and progression of complications differ between worldwide populations. While obesity is a major…”
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Multi-SNP mediation intersection-union test by Zhong, Wujuan, Spracklen, Cassandra N, Mohlke, Karen L, Zheng, Xiaojing, Fine, Jason, Li, Yun

“…Abstract Summary Tens of thousands of reproducibly identified GWAS (Genome-Wide Association Studies) variants, with the vast majority falling in non-coding…”
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Validation of birth certificate and maternal recall of events in labor and delivery with medical records in the Iowa health in pregnancy study by Ziogas, Christina, Hillyer, Jenna, Saftlas, Audrey F, Spracklen, Cassandra N

“…Epidemiological research of events related to labor and delivery frequently uses maternal interview or birth certificates as a primary method of data…”
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Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey by Spracklen, Cassandra N, Shi, Jinxiu, Vadlamudi, Swarooparani, Wu, Ying, Zou, Meng, Raulerson, Chelsea K, Davis, James P, Zeynalzadeh, Monica, Jackson, Kayla, Yuan, Wentao, Wang, Haifeng, Shou, Weihua, Wang, Ying, Luo, Jingchun, Lange, Leslie A, Lange, Ethan M, Popkin, Barry M, Gordon-Larsen, Penny, Du, Shufa, Huang, Wei, Mohlke, Karen L

“…To identify genetic contributions to type 2 diabetes (T2D) and related glycemic traits (fasting glucose, fasting insulin, and HbA1c), we conducted genome-wide…”
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Associations between birthweight and preterm birth and the ages at menarche and menopause by Daniele, Christian, Wacks, Rachel E, Farland, Leslie V, Manson, JoAnn E, Qi, Lihong, Shadyab, Aladdin H, Wassertheil-Smoller, Sylvia, Spracklen, Cassandra N

“…Women who reach menarche and menopause at earlier ages have been shown to be at increased risk for numerous conditions including cardiovascular disease,…”
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Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels by Spracklen, Cassandra N, Chen, Peng, Kim, Young Jin, Wang, Xu, Cai, Hui, Li, Shengxu, Long, Jirong, Wu, Ying, Wang, Ya Xing, Takeuchi, Fumihiko

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Adipose Tissue Gene Expression Associations Reveal Hundreds of Candidate Genes for Cardiometabolic Traits by Raulerson, Chelsea K., Ko, Arthur, Kidd, John C., Currin, Kevin W., Brotman, Sarah M., Cannon, Maren E., Wu, Ying, Spracklen, Cassandra N., Jackson, Anne U., Stringham, Heather M., Welch, Ryan P., Fuchsberger, Christian, Locke, Adam E., Narisu, Narisu, Lusis, Aldons J., Civelek, Mete, Furey, Terrence S., Kuusisto, Johanna, Collins, Francis S., Boehnke, Michael, Scott, Laura J., Lin, Dan-Yu, Love, Michael I., Laakso, Markku, Pajukanta, Päivi, Mohlke, Karen L.

“…Genome-wide association studies (GWASs) have identified thousands of genetic loci associated with cardiometabolic traits including type 2 diabetes (T2D), lipid…”
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Association of maternal birth weight and maternal preterm birth with subsequent risk for adverse reproductive outcomes: The Women's Health Initiative by Daniele, Christian, Farland, Leslie V., Park, Ki, Schnatz, Peter F., Shadyab, Aladdin H., Stefanick, Marcia L., Wactawski-Wende, Jean, Wild, Robert A., Spracklen, Cassandra N.

“…Advancements in medical technology and pharmacologic interventions have drastically improved survival of infants born preterm and low birth weight, but…”
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Prostaglandins temporally regulate cytoplasmic actin bundle formation during Drosophila oogenesis by Spracklen, Andrew J, Kelpsch, Daniel J, Chen, Xiang, Spracklen, Cassandra N, Tootle, Tina L

“…Prostaglandins (PGs)--lipid signals produced downstream of cyclooxygenase (COX) enzymes--regulate actin dynamics in cell culture and platelets, but their roles…”
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Physical Activity During Pregnancy and Subsequent Risk of Preeclampsia and Gestational Hypertension: A Case Control Study by Spracklen, Cassandra N., Ryckman, Kelli K., Triche, Elizabeth W., Saftlas, Audrey F.

“…Objective Physical activity (PA) is hypothesized to reduce the risk of preeclampsia, but few epidemiologic studies have simultaneously evaluated leisure time…”
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A cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin by Sarsani, Vishal, Brotman, Sarah M, Xianyong, Yin, Fernandes Silva, Lillian, Laakso, Markku, Spracklen, Cassandra N

“…Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 diabetes and obesity, identified >20 associated loci…”
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Inferring Regulatory Networks From Mixed Observational Data Using Directed Acyclic Graphs by Zhong, Wujuan, Dong, Li, Poston, Taylor B, Darville, Toni, Spracklen, Cassandra N, Wu, Di, Mohlke, Karen L, Li, Yun, Li, Quefeng, Zheng, Xiaojing

“…Construction of regulatory networks using cross-sectional expression profiling of genes is desired, but challenging. The Directed Acyclic Graph (DAG) provides…”
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Birthweight and subsequent risk for thyroid and autoimmune conditions in postmenopausal women by Monahan, Brian, Farland, Leslie V, Shadyab, Aladdin H, Hankinson, Susan E, Manson, JoAnn E, Spracklen, Cassandra N

“…The objective of this study was to determine the association between birthweight and risk of thyroid and autoimmune conditions in a large sample of…”
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Adiponectin GWAS loci harboring extensive allelic heterogeneity exhibit distinct molecular consequences by Spracklen, Cassandra N, Iyengar, Apoorva K, Vadlamudi, Swarooparani, Raulerson, Chelsea K, Jackson, Anne U, Brotman, Sarah M, Wu, Ying, Cannon, Maren E, Davis, James P, Crain, Aaron T, Currin, Kevin W, Perrin, Hannah J, Narisu, Narisu, Stringham, Heather M, Fuchsberger, Christian, Locke, Adam E, Welch, Ryan P, Kuusisto, Johanna K, Pajukanta, Päivi, Scott, Laura J, Li, Yun, Collins, Francis S, Boehnke, Michael, Laakso, Markku, Mohlke, Karen L

“…Loci identified in genome-wide association studies (GWAS) can include multiple distinct association signals. We sought to identify the molecular basis of…”
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Preterm birth, birthweight, and subsequent risk for depression by Rahalkar, Neha, Holman-Vittone, Aaron, Daniele, Christian, Wacks, Rachel, Gagnon, Autumn, D'Agata, Amy, Saquib, Nazmus, Schnatz, Peter F, Sullivan, Mary C, Wallace, Robert, Spracklen, Cassandra N

“…An individual's birthweight, a marker of exposures, was recently associated with certain psychiatric conditions. However, studies investigating the…”
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Maternal factors and complications of preterm birth associated with neonatal thyroid stimulating hormone by Ryckman, Kelli K, Spracklen, Cassandra N, Dagle, John M, Murray, Jeffrey C

“…Thyroid hormones are important regulators of fetal neurodevelopment. Among preterm infants, thyroid stimulating hormone (TSH) is highly variable. Understanding…”
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A retrospective study of administration of vaccination for hepatitis B among newborn infants prior to hospital discharge at a midwestern tertiary care center by Myers, Helen I, Spracklen, Cassandra N, Ryckman, Kelli K, Murray, Jeffrey C

“…Abstract Objectives Infants are at high risk of developing chronic, life-threatening disease as a result of hepatitis B virus infection. Universal vaccination…”
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Influence of a loop electrosurgical excision procedure (LEEP) on levels of cytokines in cervical secretions by Saftlas, Audrey F, Spracklen, Cassandra N, Ryckman, Kelli K, Stockdale, Colleen K, Penrose, Kerri, Ault, Kevin, Rubenstein, Linda M, Pinto, Ligia A

“…Highlights • LEEP has been associated with adverse reproductive outcomes. • We study changes in cervical cytokine levels in LEEP-treated patients and controls…”
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Low Birth Weight and Risk of Later-Life Physical Disability in Women by Spracklen, Cassandra N, Ryckman, Kelli K, Robinson, Jennifer G, Stefanick, Marcia L, Sarto, Gloria E, Anton, Stephen D, Wallace, Robert B

“…There is strong evidence that low and high birth weight due to in-utero programming results in elevated risk for adult diseases, though less research has been…”
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