Search Results - "Sporn, MB"

The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti–multiple myeloma (MM) activity and overcome bortezomib resistance by Chauhan, Dharminder, Li, Guilan, Podar, Klaus, Hideshima, Teru, Shringarpure, Reshma, Catley, Laurence, Mitsiades, Constantine, Munshi, Nikhil, Tai, Yu Tzu, Suh, Nanjoo, Gribble, Gordon W., Honda, Tadashi, Schlossman, Robert, Richardson, Paul, Sporn, Michael B., Anderson, Kenneth C.

“…The synthetic triterpenoid 2-cyano-3, 12-dioxooleana-1, 9-dien-28-oic acid (CDDO) induces apoptosis in leukemic cells. Here we show that CDDO and its new…”
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Role of Transforming Growth Factor-β in the Development of the Mouse Embryo by Heine, Ursula I., Munoz, Eliana F., Flanders, Kathleen C., Ellingsworth, Larry R., H.-Y. Peter Lam, Thompson, Nancy L., Roberts, Anita B., Sporn, Michael B.

“…Using immunohistochemical methods, we have investigated the role of transforming growth factor-β (TGF-β) in the development of the mouse embryo. For detection…”
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Chemoprevention: an essential approach to controlling cancer by Sporn, Michael B, Suh, Nanjoo

“…Mortality that results from the common forms of cancer is still unacceptably high. Despite immense advances in the understanding of the mechanisms of…”
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The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice by Liu, Manchang, Reddy, Narsa M, Higbee, Elizabeth M, Potteti, Haranatha R, Noel, Sanjeev, Racusen, Lorraine, Kensler, Thomas W, Sporn, Michael B, Reddy, Sekhar P, Rabb, Hamid

“…Acute kidney injury (AKI) caused by ischemia-reperfusion is a major clinical problem in both native and transplanted kidneys. We had previously shown that…”
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The transforming growth factor-betas: past, present, and future by Sporn, M B, Roberts, A B

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Cancer chemoprevention: scientific promise, clinical uncertainty by Sporn, Michael B, Liby, Karen T

“…We review fundamental processes, such as mutation, oxidative stress, and inflammation that are critical for carcinogenesis and provide specific molecular…”
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Extremely Potent Triterpenoid Inducers of the Phase 2 Response: Correlations of Protection against Oxidant and Inflammatory Stress by Dinkova-Kostova, Albena T., Liby, Karen T., Stephenson, Katherine K., Holtzclaw, W. David, Gao, Xiangqun, Suh, Nanjoo, Williams, Charlotte, Risingsong, Renee, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., Talalay, Paul

“…A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-γ…”
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Chemoprevention of cancer by Sporn, Michael B., Suh, Nanjoo

“…In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to…”
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling by LIBY, Karen, HOCK, Thomas, GRIBBLE, Gordon W, HILL-KAPTURCZAK, Nathalie, AGARWAL, Anupam, SPORN, Michael B, YORE, Mark M, SUH, Nanjoo, PLACE, Andrew E, RISINGSONG, Renee, WILLIAMS, Charlotte R, ROYCE, Darlene B, HONDA, Tadashi, HONDA, Yukiko

“…The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its derivative…”
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Recent Advances in Chemoprevention of Cancer by Hong, Waun Ki, Sporn, Michael B.

“…Chemoprevention is the use of pharmacologic or natural agents that inhibit the development of invasive cancer either by blocking the DNA damage that initiates…”
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c-Jun NH2-Terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells by WEI ZOU, XIANGGUO LIU, PING YUE, ZHONGMEI ZHOU, SPORN, Michael B, LOTAN, Reuben, KHURI, Fadlo R, SUN, Shi-Yong

“…Death receptor (DR) 4 or 5, on binding to its ligand, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), triggers apoptosis via activating the…”
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The war on cancer by Sporn, M B

“…25 years ago, then President Nixon "declared" War on Cancer. In this personal commentary, the war is reviewed. There have been obvious triumphs, for instance…”
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Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole by Yates, Melinda S, Kwak, Mi-Kyoung, Egner, Patricia A, Groopman, John D, Bodreddigari, Sridevi, Sutter, Thomas R, Baumgartner, Karen J, Roebuck, B D, Liby, Karen T, Yore, Mark M, Honda, Tadashi, Gribble, Gordon W, Sporn, Michael B, Kensler, Thomas W

“…Synthetic triterpenoid analogues of oleanolic acid are potent inducers of the phase 2 response as well as inhibitors of inflammation. We show that the…”
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Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells by Hyer, Marc L, Croxton, Rhonda, Krajewska, Maryla, Krajewski, Stanislaw, Kress, Christina L, Lu, Meiling, Suh, Nanjoo, Sporn, Michael B, Cryns, Vincent L, Zapata, Juan M, Reed, John C

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL or Apo2L) has been shown to induce apoptosis specifically in cancer cells while sparing normal…”
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The early history of TGF-β, and a brief glimpse of its future by Sporn, Michael B.

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The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia by KONOPLEVA, Marina, TSAO, Twee, KANTARJIAN, Hagop, SPORN, Michael B, ANDREEFF, Michael, ESTROV, Zeev, LEE, Ruey-Min, WANG, Rui-Yu, JACKSON, C. Ellen, MCQUEEN, Teresa, MONACO, Giuseppe, MUNSELL, Mark, BELMONT, John

“…In acute myeloid leukemia (AML), resistance to chemotherapy is associated with defects in both the extrinsic and intrinsic pathways of apoptosis. Novel agents…”
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Ursolic acid inhibits cyclooxygenase-2 transcription in human mammary epithelial cells by SUBBARAMAIAH, K, MICHALUART, P, SPORN, M. B, DANNENBERG, A. J

“…We investigated the effects of ursolic acid, a chemopreventive agent, on the expression of cyclooxygenase-2 (COX-2) in phorbol 12-myristate 13-acetate…”
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Prospects for prevention and treatment of cancer with selective PPARγ modulators (SPARMs) by Sporn, Michael B, Suh, Nanjoo, Mangelsdorf, David J

“…Peroxisome proliferator-activated receptor γ (PPARγ), a nuclear receptor and transcription factor that regulates the expression of many genes relevant to…”
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A new ligand for the peroxisome proliferator-activated receptor-γ (PPAR-γ), GW7845, inhibits rat mammary carcinogenesis by NANJOO SUH, YONGPING WANG, WILLIAMS, C. R, RISINGSONG, R, GILMER, T, WILLSON, T. M, SPORN, M. B

“…We have tested a new ligand for peroxisome proliferator-activated receptor-gamma, GW7845, as an inhibitor of experimental mammary carcinogenesis, using the…”
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Synthetic Oleanane and Ursane Triterpenoids with Modified Rings A and C:  A Series of Highly Active Inhibitors of Nitric Oxide Production in Mouse Macrophages by Honda, Tadashi, Rounds, BarbieAnn V, Bore, Lothar, Finlay, Heather J, Favaloro, Frank G, Suh, Nanjoo, Wang, Yongping, Sporn, Michael B, Gribble, Gordon W

“…We have designed and synthesized 16 new olean- and urs-1-en-3-one triterpenoids with various modified rings C as potential antiinflammatory and cancer…”
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