Search Results - "Sporková, Alexandra"

Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats’ Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids by Sporková, Alexandra, PhD, Reddy, Rami N., PhD, Falck, John R., PhD, Imig, John D., PhD, Kopkan, Libor, DVM, PhD, Sadowski, Janusz, PhD, Červenka, Luděk, MD, PhD

“…Abstract Background Small renal arteries have a significant role in the regulation of renal hemodynamics and blood pressure (BP). To study potential changes in…”
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Lin11-Isl1-Mec3 Domain Proteins as Mechanotransducers in Endothelial and Vascular Smooth Muscle Cells by Sporkova, Alexandra, Ghosh, Subhajit, Al-Hasani, Jaafar, Hecker, Markus

“…Arterial hypertension is the leading risk factor for cardiovascular morbidity and mortality worldwide. However, little is known about the cellular mechanisms…”
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Tracing G-Protein-Mediated Contraction and Relaxation in Vascular Smooth Muscle Cell Spheroids by Garg, Jaspal, Sporkova, Alexandra, Hecker, Markus, Korff, Thomas

“…Analyses of G-protein-mediated contraction and relaxation of vascular smooth muscle cells (VSMCs) are usually hampered by a rigid growth surface and culture…”
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Fenofibrate Attenuates Hypertension in Goldblatt Hypertensive Rats: Role of 20-Hydroxyeicosatetraenoic Acid in the Nonclipped Kidney by Sporková, Alexandra, Ph.D, Čertíková Chábová, Věra, M.D., Ph.D, Doleželová, Šárka, M.Sc, Jíchová, Šárka, M.Sc, Kopkan, Libor, DVM, Ph.D, Vaňourková, Zdenka, Ph.D, Kompanowska-Jezierska, Elzbieta, Ph.D, Sadowski, Janusz, M.D., Ph.D, Maxová, Hana, Červenka, Luděk, M.D., Ph.D

“…Abstract Background There is vast evidence that the renin-angiotensin system is not the sole determinant of blood pressure (BP) elevation in human renovascular…”
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Characterisation of Lipoma-Preferred Partner as a Novel Mechanotransducer in Vascular Smooth Muscle Cells by Sporkova, Alexandra, Nahar, Taslima, Cao, Mingsi, Ghosh, Subhajit, Sens-Albert, Carla, Friede, Prisca Amayi Patricia, Nagel, Anika, Al-Hasani, Jaafar, Hecker, Markus

“…In arteries and arterioles, a chronic increase in blood pressure raises wall tension. This continuous biomechanical strain causes a change in gene expression…”
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Role of cytochrome P-450 metabolites in the regulation of renal function and blood pressure in 2-kidney 1-clip hypertensive rats by Sporková, Alexandra, Kopkan, Libor, Varcabová, Sárka, Husková, Zuzana, Hwang, Sung Hee, Hammock, Bruce D, Imig, John D, Kramer, Herbert J, Cervenka, Ludek

“…Alterations in renal function contribute to Goldblatt two-kidney, one-clip (2K1C) hypertension. A previous study indicated that bioavailability of cytochrome…”
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Different mechanisms of acute versus long-term antihypertensive effects of soluble epoxide hydrolase inhibition: Studies in Cyp1a1-Ren-2 transgenic rats by Sporková, Alexandra, Jíchová, Šárka, Husková, Zuzana, Kopkan, Libor, Nishiyama, Akira, Hwang, Sung H, Hammock, Bruce D, Imig, John D, Kompanowska-Jezierska, Elzbieta, Sadowski, Janusz, Kramer, Herbert J, Červenka, Luděk

“…Summary Recent studies have shown that the long‐term antihypertensive action of soluble epoxide hydrolase inhibition (sEH) in angiotensin‐II (AngII)‐dependent…”
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Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME by Honetschlägerová, Zuzana, Kitada, Kento, Husková, Zuzana, Sporková, Alexandra, Kopkan, Libor, Bürgelová, Marcela, Varcabová, Šárka, Nishiyama, Akira, Hwang, Sung Hee, Hammock, Bruce D, Imig, John D, Kramer, Herbert J, Kujal, Petr, Vernerová, Zdenka, Červenka, Luděk

“…OBJECTIVE:The present study was performed to investigate in a model of malignant hypertension if the antihypertensive actions of soluble epoxide hydrolase…”
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Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats by Alánová, Petra, Husková, Zuzana, Kopkan, Libor, Sporková, Alexandra, Jíchová, Šárka, Neckář, Jan, Imig, John D, Klevstig, Martina, Kolář, František, Rami Reddy, N, Falck, John R, Sadowski, Janusz, Nishiyama, Akira, Kramer, Herbert J, Melenovský, Vojtěch, Červenková, Lenka, Kujal, Petr, Vernerová, Zdenka, Červenka, Luděk

“…Abstract This study examined the effects of a novel orally active 14,15-epoxyeicosatrienoic acid analog (EET-A) on blood pressure (BP) and myocardial infarct…”
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Renal mechanisms contributing to the antihypertensive action of soluble epoxide hydrolase inhibition in Ren‐2 transgenic rats with inducible hypertension by Honetschlägerová, Zuzana, Husková, Zuzana, Vaňourková, Zdeňka, Sporková, Alexandra, Kramer, Herbert J., Hwang, Sung Hee, Tsai, Hsing‐Ju, Hammock, Bruce D., Imig, John D., Červenka, Luděk, Kopkan, Libor

“…Non‐technical summary Arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) influence vascular tone and renal tubular sodium and water transport…”
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Inhibition of soluble epoxide hydrolase improves the impaired pressure–natriuresis relationship and attenuates the development of hypertension and hypertension-associated end-organ damage in Cyp1a1-Ren-2 transgenic rats by Honetschlägerová, Zuzana, Sporková, Alexandra, Kopkan, Libor, Husková, Zuzana, Hwang, Sung H, Hammock, Bruce D, Imig, John D, Kramer, Herbert J, Kujal, Petr, Vernerová, Zdenka, Chábová, Věra Č, Tesař, Vladimír, Červenka, Luděk

“…OBJECTIVEIn the present study, we compared the effects of treatment with the novel soluble epoxide hydrolase (sEH) inhibitor (c-AUCB) with those of the AT1…”
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Soluble Epoxide Hydrolase Inhibition Exhibits Antihypertensive Actions Independently of Nitric Oxide in Mice with Renovascular Hypertension by Kopkan, Libor, Husková, Zuzana, Sporková, Alexandra, Varcabová, Šárka, Honetschlägerová, Zuzana, Hwang, Sung Hee, Tsai, Hsing-Ju, Hammock, Bruce D., Imig, John D., Kramer, Herbert J., Bürgelová, Marcela, Vojtíšková, Alžběta, Kujal, Petr, Vernerová, Zdenka, Červenka, Luděk

“…Objective: The present study was performed to examine whether the blood pressure (BP)-lowering effects of soluble epoxide hydrolase (sEH) inhibition in…”
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Interlobular arteries from two-kidney, one-clip Goldblatt hypertensive rats exhibit impaired vasodilator response to epoxyeicosatrienoic acids by Sporková, Alexandra, Reddy, N. Rami, Falck, John R., Imig, John D., Kopkan, Libor, Sadowski, Janusz, Červenka, Luděk

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Inhibition of soluble epoxide hydrolase does not improve the course of congestive heart failure and the development of renal dysfunction in rats with volume overload induced by aorto-caval fistula by Červenka, L, Melenovský, V, Husková, Z, Sporková, A, Bürgelová, M, Škaroupková, P, Hwang, S H, Hammock, B D, Imig, J D, Sadowski, J

“…The detailed mechanisms determining the course of congestive heart failure (CHF) and associated renal dysfunction remain unclear. In a volume overload model of…”
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Interaction between α1- and α2-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries by SPORKOVA, Alexandra, PEREZ-RIVERA, Alex, GALLIGAN, James J

“…Mesenteric veins are more sensitive than arteries to the constrictor effects of sympathetic nerve stimulation and α-adrenoceptor agonists. We tested the…”
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Interaction between α 1- and α 2-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries by Sporkova, Alexandra, Perez-Rivera, Alex, Galligan, James J.

“…Mesenteric veins are more sensitive than arteries to the constrictor effects of sympathetic nerve stimulation and α-adrenoceptor agonists. We tested the…”
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Interaction between alpha(1)- and alpha(2)-adrenoreceptors contributes to enhanced constrictor effects of norepinephrine in mesenteric veins compared to arteries by Sporkova, Alexandra, Perez-Rivera, Alex, Galligan, James J

“…Mesenteric veins are more sensitive than arteries to the constrictor effects of sympathetic nerve stimulation and alpha-adrenoceptor agonists. We tested the…”
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