Search Results - "Spooner, Paul R."

High-resolution genotyping and mapping of recombination and gene conversion in the protozoan Theileria parva using whole genome sequencing by Henson, Sonal, Bishop, Richard P, Morzaria, Subhash, Spooner, Paul R, Pelle, Roger, Poveda, Lucy, Ebeling, Martin, Küng, Erich, Certa, Ulrich, Daubenberger, Claudia A, Qi, Weihong

“…Theileria parva is a tick-borne protozoan parasite, which causes East Coast Fever, a disease of cattle in sub-Saharan Africa. Like Plasmodium falciparum, the…”
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Two Theileria parva CD8 T cell antigen genes are more variable in buffalo than cattle parasites, but differ in pattern of sequence diversity by Pelle, Roger, Graham, Simon P, Njahira, Moses N, Osaso, Julius, Saya, Rosemary M, Odongo, David O, Toye, Philip G, Spooner, Paul R, Musoke, Anthony J, Mwangi, Duncan M, Taracha, Evans L N, Morrison, W Ivan, Weir, William, Silva, Joana C, Bishop, Richard P

“…Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized…”
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Multilocus genotyping of Theileria parva isolates associated with a live vaccination trial in Kenya provides evidence for transmission of immunizing parasites into local tick and cattle populations by Bishop, Richard P., Odongo, David O., Spooner, Paul R., Morzaria, Subhash P., Oura, Chris A. L., Skilton, Robert A.

“…The live infection and treatment (ITM) vaccination procedure using the trivalent Muguga cocktail is increasingly being used to control East Coast fever, with…”
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Molecular evolution of a central region containing B cell epitopes in the gene encoding the p67 sporozoite antigen within a field population of Theileria parva by Obara, Isaiah, Ulrike, Seitzer, Musoke, Tony, Spooner, Paul R, Jabbar, Ahmed, Odongo, David, Kemp, Stephen, Silva, Joana C, Bishop, Richard P

“…Protective immunity induced by the infective sporozoite stage of Theileria parva indicates a potential role for antibodies directed against conserved…”
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Relative Orientation between the β-Ionone Ring and the Polyene Chain for the Chromophore of Rhodopsin in Native Membranes by Spooner, Paul J. R, Sharples, Jonathan M, Verhoeven, Michiel A, Lugtenburg, Johan, Glaubitz, Clemens, Watts, Anthony

“…Rotational resonance solid state nuclear magnetic resonance has been used to determine the relative orientation of the β-ionone ring and the polyene chain of…”
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Conformational Similarities in the β-Ionone Ring Region of the Rhodopsin Chromophore in Its Ground State and after Photoactivation to the Metarhodopsin-I Intermediate by Spooner, Paul J. R, Sharples, Jonathan M, Goodall, Scott C, Seedorf, Henning, Verhoeven, Michiel A, Lugtenburg, Johan, Bovee-Geurts, Petra H. M, DeGrip, Willem J, Watts, Anthony

“…High-resolution solid-state NMR methods have been used to analyze the conformation of the chromophore in the late photointermediate metarhodopsin-I, from…”
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Structural Information on a Membrane Transport Protein from Nuclear Magnetic Resonance Spectroscopy Using Sequence-Selective Nitroxide Labeling by Spooner, Paul J. R, Veenhoff, Liesbeth M, Watts, Anthony, Poolman, Bert

“…The lactose transport protein (LacS) from Streptococcus thermophilus bearing a single cysteine mutation, K373C, within the putative interhelix loop 10−11 has…”
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Cytochrome c interactions with cardiolipin in bilayers: a multinuclear magic-angle spinning NMR study by Spooner, Paul J. R, Watts, Anthony

“…The influence of cytochrome c binding to cardiolipin bilayers on the motional characteristics of each component has been analyzed by magic-angle spinning (MAS)…”
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Drug therapy for heart failure in older patients —what do they want by Zachariah, Donah, Taylor, Jacqueline, Rowell, Nigel, Spooner, Clare, Kalra, Paul R

“…Chronic heart failure （CHF） is predominantly seen in older patients, and therefore real life medicine often requires the extrapolation of findings from trials…”
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NMR Observation of Substrate in the Binding Site of an Active Sugar-H+Symport Protein in Native Membranes by Paul J. R. Spooner, Rutherford, Nicholas G., Watts, Anthony, Peter J. F. Henderson

“…NMR methods have been adopted to observe directly the characteristics of substrate binding to the galactose-H+symport protein GalP, in its native environment,…”
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Structural descriptions of ligands in their binding site of integral membrane proteins at near physiological conditions using solid-state NMR by Watts, A., Burnett, I. J., Glaubitz, Clemens, Gröbner, Gerhard, Middleton, David A., Spooner, Paul J. R., Williamson, Philip T. F.

“…Using solid-state NMR approaches, it is now possible to define the structure and dynamics of binding for a small, isotopically (^sup 2^H, ^sup 13^C, ^sup 19^F,…”
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Effect of free cholesterol on incorporation of triolein in phospholipid bilayers by Spooner, Paul J. R, Small, Donald M

“…Triacylglycerols are the major substrates for lipolytic enzymes that act at the surface of emulsion-like particles such as triglyceride-rich lipoproteins,…”
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Reversible unfolding of cytochrome c upon interaction with cardiolipin bilayers. II. Evidence from phosphorus-31 NMR measurements by Spooner, Paul J. R, Watts, Anthony

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Reversible unfolding of cytochrome c upon interaction with cardiolipin bilayers. I. Evidence from deuterium NMR measurements by Spooner, Paul J. R, Watts, Anthony

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The Ring of the Rhodopsin Chromophore in a Hydrophobic Activation Switch Within the Binding Pocket by Spooner, Paul J.R., Sharples, Jonathan M., Goodall, Scott C., Bovee-Geurts, Petra H.M., Verhoeven, Michiel A., Lugtenburg, Johan, Pistorius, Arthur M.A., DeGrip, Willem J., Watts, Anthony

“…The current view that the β-ionone ring of the rhodopsin chromophore vacates its binding pocket within the protein early in the photocascade has been adopted…”
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Molecular characterisation of a Theileria lestoquardi gene encoding a candidate sporozoite vaccine antigen by Skilton, Robert A., Musoke, Anthony J., Nene, Vishvanath, Wasawo, Delia P.S., Wells, Clive W., Spooner, Paul R., Bishop, Richard P., Osaso, Julius, Nkonge, Catherine, Latif, Abdulla, Morzaria, Subhash P.

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Rotational Mobility and Orientational Stability of a Transport Protein in Lipid Membranes by Spooner, Paul J.R., Friesen, Robert H.E., Knol, Jan, Poolman, Bert, Watts, Anthony

“…A single-cysteine mutant of the lactose transport protein LacS(C320A/W399C) from Streptococcus thermophilus was selectively labeled with a nitroxide spin…”
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SfiI and NotI polymorphisms in Theileria stocks detected by pulsed field gel electrophoresis by Morzaria, S P, Spooner, P R, Bishop, R P, Musoke, A J, Young, J R

“…DNAs of Theileria parva parva, T. p. lawrencei, T. p. bovis and Theileria mutans stocks, from Kenya, Uganda, Zanzibar and Zimbabwe were digested with either…”
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Membrane protein structure determination by solid state NMR by Watts, A, Burnett, I J, Glaubitz, C, Gröbner, G, Middleton, D A, Spooner, P J, Watts, J A, Williamson, P T

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Production in ascites fluid of biosynthetically labelled monoclonal antibody to Theileria parva sporozoites by Dobbelaere, D A, Spooner, P R

“…A hybridoma cell line has been previously produced which secretes monoclonal antibodies able to neutralize sporozoites of Theileria parva, the causative agent…”
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