Search Results - "Spooner, Edward T."

Evidence for peripheral clearance of cerebral Aβ protein following chronic, active Aβ immunization in PSAPP mice by Lemere, Cynthia A, Spooner, Edward T, LaFrancois, John, Malester, Brian, Mori, Chica, Leverone, Jodi F, Matsuoka, Yasuji, Taylor, Jennie W, DeMattos, Ronald B, Holtzman, David M, Clements, John D, Selkoe, Dennis J, Duff, Karen E

“…Immunization with amyloid-β (Aβ) peptide in mouse models of Alzheimer’s disease has been reported to decrease cerebral Aβ levels and improve behavioral…”
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Amyloid β protein immunotherapy neutralizes Aβ oligomers that disrupt synaptic plasticity in vivo by Selkoe, Dennis J, Rowan, Michael J, Klyubin, Igor, Walsh, Dominic M, Lemere, Cynthia A, Cullen, William K, Shankar, Ganesh M, Betts, Vicki, Spooner, Edward T, Jiang, Liying, Anwyl, Roger

“…One of the most clinically advanced forms of experimental disease-modifying treatment for Alzheimer disease is immunization against the amyloid β protein (Aβ),…”
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The vanadium-bearing oxide minerals of the Green Giant vanadium-graphite deposit, southwest Madagascar by Di Cecco, Veronica E, Tait, Kimberly T, Spooner, Edward T. C, Scherba, Craig

“…Rare vanadium-rich oxide minerals have been previously identified in graphite-bearing quartzo-feldspathic gneisses derived from shale protoliths. In this work,…”
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Alzheimer's Disease Aβ Vaccine Reduces Central Nervous System Aβ Levels in a Non-Human Primate, the Caribbean Vervet by Lemere, Cynthia A., Beierschmitt, Amy, Iglesias, Melitza, Spooner, Edward T., Bloom, Jeanne K., Leverone, Jodi F., Zheng, Jessica B., Seabrook, Timothy J., Louard, Dora, Li, Diana, Selkoe, Dennis J., Palmour, Roberta M., Ervin, Frank R.

“…Amyloid β (Aβ) protein immunotherapy lowers cerebral Aβ and improves cognition in mouse models of Alzheimer's disease (AD). Here we show that Caribbean vervet…”
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Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease by Weiner, Howard L., Lemere, Cynthia A., Maron, Ruth, Spooner, Edward T., Grenfell, Trelawney J., Mori, Chica, Issazadeh, Shohreh, Hancock, Wayne W., Selkoe, Dennis J.

“…Progressive cerebral deposition of amyloid‐β (Aβ) peptide, an early and essential feature of Alzheimer's disease (AD), is accompanied by an inflammatory…”
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Intranasal immunotherapy for the treatment of Alzheimer's disease: Escherichia coli LT and LT(R192G) as mucosal adjuvants by LEMERE, Cynthia A, SPOONER, Edward T, LEVERONE, Jodi F, MORI, Chica, CLEMENTS, John D

“…Alzheimer's disease (AD) is the most common form of dementia worldwide, yet there is currently no effective treatment or cure. Extracellular deposition of…”
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Aβ1-15 is less immunogenic than Aβ1-40/42 for intranasal immunization of wild-type mice but may be effective for “boosting” by Leverone, Jodi F., Spooner, Edward T., Lehman, Herman K., Clements, John D., Lemere, Cynthia A.

“…Immunizing mouse models of Alzheimer’s disease (AD) against β-amyloid (Aβ) leads to a decrease in cerebral Aβ burden as well as an improvement in behavioral…”
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The generation and characterization of potentially therapeutic Aβ antibodies in mice: differences according to strain and immunization protocol by Spooner, Edward T, Desai, Roanak V, Mori, Chica, Leverone, Jodi F, Lemere, Cynthia A

“…Previous studies have shown that in various mouse models of Alzheimer’s disease (AD), amyloid β-protein (Aβ) antibodies generated by Aβ peptide immunization…”
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Species-specific immune response to immunization with human versus rodent Aβ peptide by Seabrook, Timothy J, Bloom, Jeanne K, Iglesias, Melitza, Spooner, Edward T, Walsh, Dominic M, Lemere, Cynthia A

“…Amyloid beta (Aβ) immunization of amyloid precursor protein (APP)-transgenic (tg) mice with human Aβ induces humoral immunity, however, the immune response to…”
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Fluid chemistry of Archean seafloor hydrothermal vents: Implications for the composition of circa 3.2 Ga seawater by De Ronde, Cornel E.J., Channer, Dominic M.deR, Faure, Kevin, Bray, Colin J., Spooner, Edward T.C.

“…Seafloor hydrothermal vents of mid-Archean age (ca. 3230 Ma) have been identified and mapped in the Barberton greenstone belt, South Africa and are known as…”
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Differences in the immune response to long term Aβ vaccination in C57BL/6 and B6D2F1 mice by Seabrook, Timothy J., Iglesias, Melitza, Bloom, Jeanne K., Spooner, Edward T., Lemere, Cynthia A.

“…The cerebral accumulation of β-amyloid (Aβ) is a pathological hallmark of Alzheimer’s disease (AD). Aβ vaccination or anti-Aβ specific antibodies may be a…”
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Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma by Kinlaw, William B., Scott, Sarah M., Maue, Robert A., Memoli, Vincent A., Harris, Robert D., Daniels, Gilbert H., Porter, Donna M., Belloni, Dorothy R., Spooner, Edward T., Ernesti, Manfred M., Noll, Walter W.

“…Summary Objective   We have identified a large kindred with multiple endocrine neoplasia 2A (MEN 2A) due to a mutation at RET codon 609 that results in a…”
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Immunocytochemistry of formalin-fixed human brain tissues: microwave irradiation of free-floating sections by Shiurba, Robert A, Spooner, Edward T, Ishiguro, Koichi, Takahashi, Miho, Yoshida, Rie, Wheelock, Timothy R, Imahori, Kazutomo, Cataldo, Anne M, Nixon, Ralph A

“…Formalin fixation, the chemical process in which formaldehyde binds to cells and tissues, is widely used to preserve human brain specimens from autolytic…”
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Amyloid-beta immunization in Alzheimer's disease transgenic mouse models and wildtype mice by Lemere, Cynthia A, Spooner, Edward T, Leverone, Jodi F, Mori, Chica, Iglesias, Melitza, Bloom, Jeanne K, Seabrook, Timothy J

“…Alzheimer's disease is the most prevalent form of dementia worldwide. Therapies are desperately needed to prevent and cure the disease. Mouse models of…”
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Immunocytochemistry of tau phosphoserine 413 and tau protein kinase I in Alzheimer pathology by Shiurba, Robert A., Ishiguro, Koichi, Takahashi, Miho, Sato, Kazuki, Spooner, Edward T., Mercken, Marc, Yoshida, Rie, Wheelock, Timothy R., Yanagawa, Hiroshi, Imahori, Kazutomo, Nixon, Ralph A.

“…One unique phosphorylation site consistently found in paired helical filament tau, serine 413, is modified by tau protein kinase I/glycogen synthase kinase-3β…”
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The geochemistry of the 2.75 Ga-old Helen Iron Formation, Wawa, Ontario – Insights into iron formation deposition from carbon isotopes and rare earth elements by Garcia, Therese Ingrid, Gorton, Michael P., Li, Hong, Wortmann, Ulrich G., Spooner, Edward T.C.

“…•High resolution stratigraphically controlled REE and δ13C study of an iron formation.•Evidence for direct precipitation from seawater.•Two dissimilatory iron…”
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Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease by Weiner, Howard L., Lemere, Cynthia A., Maron, Ruth, Spooner, Edward T., Grenfell, Trelawney J., Mori, Chica, Issazadeh, Shohreh, Hancock, Wayne W., Selkoe, Dennis J.

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Microthermometric, laser Raman spectroscopic, and volatile-ion chromatographic analysis of hydrothermal fluids in the Paleozoic Muruntau-Au-bearing quartz vein ore field, Uzbekistan by Graupner, Torsten, Kempe, Ulf, Spooner, Edward T. C, Bray, Colin J, Kremenetsky, Alexander A, Irmer, Gert

“…Fluid inclusions in quartz and scheelite from flat, steeply dipping central, and stockwork-type quartz veins within the Muruntau Au-bearing quartz vein ore…”
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A special issue devoted to Abitibi ore deposits in a modern context; preface by Spooner, Edward T. C, Barrie, C. Tucker

“…The Abitibi belt is the largest known Archaean greenstone-granite terrain. It is approx 300 km in the N-S direction and approx 400-450 km E-W. This part of the…”
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Intraneuronal Aβ42 accumulation in Down syndrome brain by Mori, Chica, Spooner, Edward T., Wisniewski, Krystyna E., Wisniewski, Thomas M., Yamaguchi, Haruyasu, Saido, Takaomi C., Tolan, Dean R., Selkoe, Dennis J., Lemere, Cynthia A.

“…Alzheimer's disease (AD) brains display A beta (Aβ) plaques, inflammatory changes and neurofibrillary tangles (NFTs). Converging evidence suggests a neuronal…”
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