Search Results - "Spooner, Chauncey J."

DNA Sequence-Dependent Compartmentalization and Silencing of Chromatin at the Nuclear Lamina by Zullo, Joseph M., Demarco, Ignacio A., Piqué-Regi, Roger, Gaffney, Daniel J., Epstein, Charles B., Spooner, Chauncey J., Luperchio, Teresa R., Bernstein, Bradley E., Pritchard, Jonathan K., Reddy, Karen L., Singh, Harinder

“…A large fraction of the mammalian genome is organized into inactive chromosomal domains along the nuclear lamina. The mechanism by which these lamina…”
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Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation by Vander Lugt, Bryan, Khan, Aly A, Hackney, Jason A, Agrawal, Smita, Lesch, Justin, Zhou, Meijuan, Lee, Wyne P, Park, Summer, Xu, Min, DeVoss, Jason, Spooner, Chauncey J, Chalouni, Cecile, Delamarre, Lelia, Mellman, Ira, Singh, Harinder

“…Dendritic cell (DC) subsets show functional specialization. Singh and colleagues demonstrate that the transcription factor IRF4 enhances antigen presentation…”
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Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1 by Spooner, Chauncey J, Lesch, Justin, Yan, Donghong, Khan, Aly A, Abbas, Alex, Ramirez-Carrozzi, Vladimir, Zhou, Meijuan, Soriano, Robert, Eastham-Anderson, Jeffrey, Diehl, Lauri, Lee, Wyne P, Modrusan, Zora, Pappu, Rajita, Xu, Min, DeVoss, Jason, Singh, Harinder

“…Type 2 innate lymphoid cells (ILC2 cells) provide early immune responses to helminthes and contribute to allergic inflammation. Singh and colleagues show that…”
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Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates by Laslo, Peter, Spooner, Chauncey J., Warmflash, Aryeh, Lancki, David W., Lee, Hyun-Jun, Sciammas, Roger, Gantner, Benjamin N., Dinner, Aaron R., Singh, Harinder

“…Hematopoietic stem cells and their progenitors exhibit multilineage patterns of gene expression. Molecular mechanisms underlying the generation and refinement…”
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A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell Fates by Spooner, Chauncey J., Cheng, Jason X., Pujadas, Elisabet, Laslo, Peter, Singh, Harinder

“…The transcription factor PU.1, encoded by the Sfpi1 gene, functions in a graded manner to regulate macrophage versus B cell generation; its higher…”
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A Genomic Regulatory Element That Directs Assembly and Function of Immune-Specific AP-1-IRF Complexes by Glasmacher, Elke, Agrawal, Smita, Chang, Abraham B., Murphy, Theresa L., Zeng, Wenwen, Lugt, Bryan Vander, Khan, Aly A., Ciofani, Maria, Spooner, Chauncey J., Rutz, Sascha, Hackney, Jason, Nurieva, Roza, Escalante, Carlos R., Ouyang, Wenjun, Dan R. Littman, Murphy, Kenneth M., Singh, Harinder

“…Interferon regulatory factor 4 (IRF4) and IRF8 regulate B, T, macrophage, and dendritic cell differentiation. They are recruited to cis-regulatory Ets-IRF…”
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In Vitro Priming of Adoptively Transferred T Cells with a RORγ Agonist Confers Durable Memory and Stemness In Vivo by Hu, Xiao, Majchrzak, Kinga, Liu, Xikui, Wyatt, Megan M, Spooner, Chauncey J, Moisan, Jacques, Zou, Weiping, Carter, Laura L, Paulos, Chrystal M

“…Adoptive T-cell transfer therapy is an FDA- approved treatment for leukemia that relies on the expansion and reinfusion of a patient's immune cells, which can…”
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Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling by Seiler, Michael P, Mathew, Rebecca, Liszewski, Megan K, Spooner, Chauncey J, Barr, Kenneth, Meng, Fanyong, Singh, Harinder, Bendelac, Albert

“…The mechanisms by which TCR signaling 'instructs' thymic lineages remain unclear. Bendelac and colleagues show that the TCR-induced transcription factor Egr2…”
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Differential roles of C/EBPβ regulatory domains in specifying MCP-1 and IL-6 transcription by Spooner, Chauncey J., Guo, Xiangrong, Johnson, Peter F., Schwartz, Richard C.

“…C/EBPβ is a member of the CCAAT/enhancer binding protein family of transcription factors and has been shown to be a critical transcriptional regulator of…”
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The C/EBP bZIP Domain Can Mediate Lipopolysaccharide Induction of the Proinflammatory Cytokines Interleukin-6 and Monocyte Chemoattractant Protein-1 by Hu, Hsien-Ming, Tian, Qiang, Baer, Mark, Spooner, Chauncey J., Williams, Simon C., Johnson, Peter F., Schwartz, Richard C.

“…C/EBPα, β, and δ are all expressed by bone marrow-derived macrophages. Ectopic expression of any of these transcription factors is sufficient to confer…”
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C/EBPβ serine 64, a phosphoacceptor site, has a critical role in LPS-induced IL-6 and MCP-1 transcription by Spooner, Chauncey J., Sebastian, Thomas, Shuman, Jon D., Durairaj, Srinivasan, Guo, Xiangrong, Johnson, Peter F., Schwartz, Richard C.

“…C/EBPβ is a member of the CCAAT/enhancer binding protein family of transcription factors and has been shown to be a critical transcriptional regulator of…”
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Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling by Seiler, Michael P, Mathew, Rebecca, Liszewski, Megan K, Spooner, Chauncey, Barr, Kenneth, Meng, Fanyong, Singh, Harinder, Bendelac, Albert

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Recurring use of a gene regulatory network to orchestrate innate and adaptive cell fates in the immune system by Spooner, Chauncey J., Cheng, Jason X., Pujadas, Elisabet, Laslo, Peter, Singh, Harinder

“…The transcription factor PU.1 functions in a graded manner to regulate macrophage versus B cell generation; its higher concentration favors the macrophage…”
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C/EBPbeta serine 64, a phosphoacceptor site, has a critical role in LPS-induced IL-6 and MCP-1 transcription by Spooner, Chauncey J, Sebastian, Thomas, Shuman, Jon D, Durairaj, Srinivasan, Guo, Xiangrong, Johnson, Peter F, Schwartz, Richard C

“…C/EBPbeta is a member of the CCAAT/enhancer binding protein family of transcription factors and has been shown to be a critical transcriptional regulator of…”
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Functional determinants of C/EBPβ in IL -6 and MCP-1 regulation by Spooner, Chauncey J

“…C/EBP transcription factors, particularly C/EBPβ and C/EBPδ, are known to play an important role in the regulation of numerous genes associated with the…”
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