Search Results - "Splinter, F K"

Protective effects of vitamin E and C on cisplatin nephrotoxicity in developing rats by APPENROTH, D, FRÖB, S, KERSTEN, L, SPLINTER, F.-K, WINNEFELD, K

“…The kinetics of vitamin E was followed in serum, liver and kidney of 10- and 55-day-old rats after the administration of a single i.m. dose of 100 mg…”
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Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin by Kuhn, U.D., Splinter, F.K., Rost, M., Müller, D.

“…7-ethoxycoumarin (EC) is widely used as a model substrate for monooxygenase function, its O-deethylation representing cytochrome P450 (P450) activity mainly of…”
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Prepartal lactose concentration in the mammary glands of Uje: WIST rats as a simple indicator of approaching parturition by Glöckner, R, Splinter, F K

“…Immediately after delivery, lactose was reliably detectable in rat mammary glands (mean concentration 6.49 +/- 0.57 mg/g tissue). The concentrations were not…”
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Experimental treatment of thioacetamide-induced liver cirrhosis by metenolone acetate. A morphological and biochemical study by Kretzschmar, M, Machnik, G, Müller, A, Splinter, F K, Zimmermann, T, Klinger, W

“…The influence of metenolone acetate (1 mg/kg b.m. orally) on intact and chronically thioacetamide-injured rat liver (experimental liver cirrhosis) was…”
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The influence of "essential" phospholipids (EPL) on phase-I- and phase-II-reactions and on the glutathione status in the liver of aging rats by Klinger, W, Müller, D, Kleeberg, U, Kretzschmar, M, Splinter, F K

“…"Essential" phospholipids (EPL; polyene-phosphatidylcholine) were administered orally to aging male rats in doses of 100 and 300 mg/kg b.wt. over 10 weeks. One…”
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Influence of inducers of cytochrome P-450 on dealkylation of 7-alkoxycoumarins by Müller, D, Groh, T, Splinter, F K

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Foreword by Klinger, W., Müller, D., Splinter, F.-K.

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Pharmacokinetics of sulfamerazine, sulfamethoxypyridazine and sulfaclomide in young and adult rats by Bräunlich, H, Splinter, F K

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Influence of inducers of cytochrome P-450 on dealkylation of 7-alkoxycoumarins by Mueller, D, Groh, Th, Splinter, F K

“…The aim of this study was to find 7-alkoxycoumarins and 7-alkoxy-4-methylcoumarins whose 7-dealkylaton depends more specifically on certain P-450 forms…”
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The effect of intrahepatic cholestasis in pregnancy on various forms of cytochrome P-450-dependent biotransformation reactions by Ortweiler, W, Peiker, G, Siegert, C, Splinter, F K, Traeger, A

“…The elimination of caffeine from plasma and the excretion of the main metabolites of metamizol (noramidopyrinemethanesulphonate sodium) into the urine were…”
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Renal excretion of long term sulfonamides under fluid administration and modification of the urinary pH value by Bräunlich, H, Splinter, F K

“…The renal excretion of sulfaclomide, sulfamerazine and sulfamethoxypyridazine is delayed by increased fluid application in rats. The simultaneous…”
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The influence of chronic renal insufficiency on the demethylating activities of various cytochrome P-450 subspecies in humans by Simon, H U, Günther, K, Balogh, A, Ortweiler, W, Splinter, F K, Stein, G, Traeger, A

“…Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and metamizol (noramidopyrine methanesulfonate sodium) is mainly…”
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Elimination of caffeine and metamizol in in vivo characterization of cytochrome P-450 dependent biotransformation reactions in aged humans by Ortweiler, W, Stein, G, Simon, H U, Siegert, C, Splinter, F K, Traeger, A

“…Elimination of caffeine from plasma and excretion of main metabolites of metamizol (noramidopyrine methanesulphonate sodium) in urine were determined in young…”
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Age-related differences in the pharmacokinetic behavior of short-time sulfonamides in rats with special reference to the protein binding rate by Bräunlich, H, Splinter, F K

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Binding of p-aminohippuric acids, hydrochlorothiazide and cyclopenthiazide serum proteins in rats of various ages by Splinter, F K, Bråunlich, H

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Effect of levonorgestrel and ethinyl estradiol and their combination on biotransformation reactions by Balogh, A, Irmisch, E, Wolf, P, Letrari, S, Splinter, F K, Hempel, E, Klinger, G, Hoffmann, A

“…Caffeine is mainly metabolized by 3-methylcholanthreneinducible cytochrome P-450, whereas metamizol (Analgin) is probably mainly metabolized by the…”
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Determination of caffeine and metamizole elimination in men and women with and without hormonal contraceptives as an in vivo method for characterization of various cytochrome P-450 subspecies by Simon, H U, Ortweiler, W, Siegert, C, Splinter, F K, Balogh, A, Traeger, A M

“…Caffeine is mainly metabolized by 3-methylcholanthrene-inducible cytochrome P-450 (P-450MC) and noramidopyrine-methanesulfonate sodium (metamizol, Analgin) is…”
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Elimination of caffeine and metamizole in the menstrual cycle of the fertile female by Balogh, A, Irmisch, E, Klinger, G, Splinter, F K, Hoffmann, A

“…The elimination of caffeine from serum and that of the main metabolites of metamizol in serum were investigated in 9 healthy women on days 1, 8, 14 and 21 of…”
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The study of the in vitro effect of selenium on formation of active oxygen species and lipid peroxidation in rat liver microsomes by Lashneva, N V, Karge, E, Knells, U, Klinger, V, Splinter, F K, Tutel'ian, V A

“…In vitro influence of sodium selenite on cytochrome P-450-dependent formation of active oxygen species on lipid peroxidation (LPO) in rat liver microsomes was…”
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Altered biotransformation of phenazone, aminophenazone and codeine as evidence of early injury to rat liver after administration of carbon tetrachloride by Klinger, W, Neugebauer, A, Splinter, F K

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