Search Results - "Spivack, Simon D."

Overexpression of the MicroRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of E-cadherin by HURTEAU, Gregory J, CARLSON, J. Andrew, SPIVACK, Simon D, BROCK, Graham J

“…MicroRNAs are approximately 22-nucleotide sequences thought to interact with multiple mRNAs resulting in either translational repression or degradation. We…”
Get full text

Initial development and testing of an exhaled microRNA detection strategy for lung cancer case–control discrimination by Shi, Miao, Han, Weiguo, Loudig, Olivier, Shah, Chirag D., Dobkin, Jay B., Keller, Steven, Sadoughi, Ali, Zhu, Changcheng, Siegel, Robert E., Fernandez, Maria Katherine, DeLaRosa, Lizett, Patel, Dhruv, Desai, Aditi, Siddiqui, Taha, Gombar, Saurabh, Suh, Yousin, Wang, Tao, Hosgood, H. Dean, Pradhan, Kith, Ye, Kenny, Spivack, Simon D.

“…For detecting field carcinogenesis non-invasively, early technical development and case–control testing of exhaled breath condensate microRNAs was performed…”
Get full text

Clinical Course of Sarcoidosis in World Trade Center-Exposed Firefighters by Hena, Kerry M., Yip, Jennifer, Jaber, Nadia, Goldfarb, David, Fullam, Kelly, Cleven, Krystal, Moir, William, Zeig-Owens, Rachel, Webber, Mayris P., Spevack, Daniel M., Judson, Marc A., Maier, Lisa, Krumerman, Andrew, Aizer, Anthony, Spivack, Simon D., Berman, Jessica, Aldrich, Thomas K., Prezant, David J., Christodoulou, Vasilios, Hena, Zachary, Plotycia, Steven M., Soghier, Israa, Gritz, David, Acuna, Dianne S., Weiden, Michael D., Nolan, Anna, Diaz, Keith, Ortiz, Viola, Kelly, Kerry

“…Sarcoidosis is believed to represent a genetically primed, abnormal immune response to an antigen exposure or inflammatory trigger, with both genetic and…”
Get full text

Genome Wide Methylome Alterations in Lung Cancer by Mullapudi, Nandita, Ye, Bin, Suzuki, Masako, Fazzari, Melissa, Han, Weiguo, Shi, Miao K, Marquardt, Gaby, Lin, Juan, Wang, Tao, Keller, Steven, Zhu, Changcheng, Locker, Joseph D, Spivack, Simon D

“…Aberrant cytosine 5-methylation underlies many deregulated elements of cancer. Among paired non-small cell lung cancers (NSCLC), we sought to profile DNA…”
Get full text

Site-specific methylated reporter constructs for functional analysis of DNA methylation by Han, Weiguo, Shi, Miao, Spivack, Simon D

“…Methods to experimentally alter and functionally evaluate cytosine methylation in a site-specific manner have proven elusive. We describe a site-specific DNA…”
Get full text

Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung by Dong, Xiao, Shi, Miao, Lee, Moonsook, Toro, Rafael, Gravina, Silvia, Han, Weiguo, Yasuda, Shoya, Wang, Tao, Zhang, Zhengdong, Vijg, Jan, Suh, Yousin, Spivack, Simon D.

“…Gene regulatory analysis of highly diverse human tissues in vivo is essentially constrained by the challenge of performing genome-wide, integrated epigenetic…”
Get full text

Utility of low-dose oral aspirin challenges for diagnosis of aspirin-exacerbated respiratory disease by Jerschow, Elina, MD, MSc, Ren, Zhen, MD, PhD, Hudes, Golda, MD, PhD, Sanak, Marek, MD, PhD, Morales, Esperanza, BA, Schuster, Victor, MD, Spivack, Simon D., MD, MPH, Rosenstreich, David, MD

“…Abstract Background Aspirin-exacerbated respiratory disease (AERD) is diagnosed through graded aspirin challenges that induce hypersensitivity reactions and…”
Get full text

Genetic and epigenetic regulation of AHR gene expression in MCF-7 breast cancer cells: Role of the proximal promoter GC-rich region by Englert, Neal A., Turesky, Robert J., Han, Weiguo, Bessette, Erin E., Spivack, Simon D., Caggana, Michele, Spink, David C., Spink, Barbara C.

“…The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, contributes to carcinogenesis through its role in the regulation of cytochrome…”
Get full text

Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients by Han, Weiguo, Wang, Tao, Reilly, Andrew A, Keller, Steven M, Spivack, Simon D

“…There is a need for new, noninvasive risk assessment tools for use in lung cancer population screening and prevention programs. To investigate the technical…”
Get full text

Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines by Alberg, Anthony J, Brock, Malcolm V, Ford, Jean G, Samet, Jonathan M, Spivack, Simon D

“…Ever since a lung cancer epidemic emerged in the mid-1900 s, the epidemiology of lung cancer has been intensively investigated to characterize its causes and…”
Get full text

Validity of Messenger RNA Expression Analyses of Human Saliva by KUMAR, Shalini V, HURTEAU, Gregory J, SPIVACK, Simon D

“…Purpose: The origins of expression microarray and reverse transcription-PCR (RT-PCR) signals in human saliva were evaluated. Experimental Design: The “RNA”…”
Get full text

Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking by Huang, Zhenqiu, Sun, Shixiang, Lee, Moonsook, Maslov, Alexander Y., Shi, Miao, Waldman, Spencer, Marsh, Ava, Siddiqui, Taha, Dong, Xiao, Peter, Yakov, Sadoughi, Ali, Shah, Chirag, Ye, Kenny, Spivack, Simon D., Vijg, Jan

“…Although lung cancer risk among smokers is dependent on smoking dose, it remains unknown if this increased risk reflects an increased rate of somatic mutation…”
Get full text

DNA methylation mapping by tag-modified bisulfite genomic sequencing by Han, Weiguo, Cauchi, Stephane, Herman, James G., Spivack, Simon D.

“…A tag-modified bisulfite genomic sequencing (tBGS) method employing direct cycle sequencing of polymerase chain reaction (PCR) products at kilobase scale,…”
Get full text

Phase I and II Carcinogen Metabolism Gene Expression in Human Lung Tissue and Tumors by SPIVACK, Simon D, HURTEAU, Gregory J, FASCO, Michael J, KAMINSKY, Laurence S

“…Purpose: The regulation of carcinogen metabolism machinery may involve proximate tobacco smoke exposure, hormonal and other endogenous coregulatory factors,…”
Get full text

Smoking-Related Gene Expression in Laser Capture–Microdissected Human Lung by TAN, Xiang-Lin, TAO WANG, SHENGLI XIONG, KUMAR, Shalini V, WEIGUO HAN, SPIVACK, Simon D

“…Purpose: Interindividual differences in quantitative expression could underlie a propensity for lung cancer. To determine precise individual gene expression…”
Get full text

First-in-human study of inhaled Azacitidine in patients with advanced non-small cell lung cancer by Cheng, Haiying, Zou, Yiyu, Shah, Chirag D., Fan, Ni, Bhagat, Tushar D., Gucalp, Rasim, Kim, Mimi, Verma, Amit, Piperdi, Bilal, Spivack, Simon D., Halmos, Balazs, Perez-Soler, Roman

“…•In heavily-pretreated lung cancer patients with predominantly lung involvement, inhaled Azacitidine was feasible and well-tolerated.•Disease control was…”
Get full text

The 3 prime paradigm of the miR-200 family and other microRNAs by Brock, Graham J., Moschos, Sterghios, Spivack, Simon D., Hurteau, Gregory J.

“…The number of predicted human microRNAs in Sanger miRBase currently stands at over a thousand, with each of these in turn predicted to target numerous mRNAs…”
Get full text

A quantitative method to identify microRNAs targeting a messenger RNA using a 3′UTR RNA affinity technique by Shi, Miao, Han, Weiguo, Spivack, Simon D.

“…The identification of specific microRNAs (miRNAs) that target a given messenger RNA (mRNA) is essential for studies in gene regulation, but the available…”
Get full text

Lung Cancer Transcriptomes Refined with Laser Capture Microdissection by Lin, Juan, Marquardt, Gabrielle, Mullapudi, Nandita, Wang, Tao, Han, Weiguo, Shi, Miao, Keller, Steven, Zhu, Changcheng, Locker, Joseph, Spivack, Simon D

“…We evaluated the importance of tumor cell selection for generating gene signatures in non–small cell lung cancer. Tumor and nontumor tissue from…”
Get full text

Dietary chemoprevention strategies for induction of phase II xenobiotic-metabolizing enzymes in lung carcinogenesis: A review by Tan, Xiang-Lin, Spivack, Simon D

“…Abstract Lung cancer is the leading cause of cancer mortality for men and women in the United States and is a growing worldwide problem. Protection against…”
Get full text