Search Results - "Spitzner, Jeffrey R."

Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells by Ferguson, Anne T., Vertino, Paula M., Spitzner, Jeffrey R., Baylin, Stephen B., Muller, Mark T., Davidson, Nancy E.

“…The cytosine analog 5-aza-2′-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible mechanisms…”
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Abstract 7238: Exploring the potential of targeted DNA Nanobot delivery systems for gene delivery by Shahhoessini, Melika, Spitzner, Jeffrey R., Lucas, Christopher R., Castro, Carlos E., Halley, Patrick D.

“…Abstract Gene therapy is a cornerstone of modern medicine's quest for precision treatment to cure human disease including cancer. The current approach to gene…”
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Abstract 479: Enhanced payload delivery for acute myeloid leukemia treatment through CD37-targeting DNA nanobots by Vantangoli, Nicholas, Halley, Patrick D., Spitzner, Jeffrey R., Byrd, John C., Larkin, Karilyn T., Castro, Carlos E., Lucas, Christopher R.

“…Abstract Acute Myeloid Leukemia (AML) treatment faces considerable challenges, in particular the delivery of therapeutics with sufficient potency and…”
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A consensus sequence for cleavage by vertebrate DNA topoisomerase II by SPITZNER, J. R, MULLER, M. T

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Z-DNA Binding Protein from Chicken Blood Nuclei by Herbert, Alan G., Spitzner, Jeffrey R., Lowenhaupt, Ky, Rich, Alexander

“…A protein (Zα) that appears to be highly specific for the left-handed Z-DNA conformer has been identified in chicken blood nuclear extracts. Zα activity is…”
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DNA topoisomerase II cleavage of telomeres in vitro and in vivo by Yoon, Hee Jei, Choi, In Young, Kang, Mi Ran, Kim, Soung Soo, Muller, Mark T, Spitzner, Jeffrey R, Chung, In Kwon

“…In this work, we have analyzed the reactivity of DNA topoisomerase II with telomeric DNA both in vitro and in vivo. Topoisomerase II cleavage reactions were…”
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Role of Estrogen Receptor Gene Demethylation and DNA Methyltransferase·DNA Adduct Formation in 5-Aza-2′deoxycytidine-induced Cytotoxicity In Human Breast Cancer Cells by Anne T. Ferguson, Paula M. Vertino, Jeffrey R. Spitzner, Stephen B. Baylin, Mark T. Muller, Nancy E. Davidson

“…The cytosine analog 5-aza-2′-deoxycytidine is a potent inhibitor of DNA methyltransferase. Its cytotoxicity has been attributed to several possible…”
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Analysis of eukaryotic topoisomerase II cleavage sites in the presence of the quinolone CP-115,953 reveals drug-dependent and -independent recognition elements by Spitzner, J R, Chung, I K, Gootz, T D, McGuirk, P R, Muller, M T

“…The quinolone derivative CP-115,953 [6,8-difluoro-7-(4-hydroxyphenyl)-1-cyclopropyl-4-quinolone-3-carboxylic acid] has been shown to induce eukaryotic…”
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Molecular structure of the halogenated anti-cancer drug iododoxorubicin complexed with d(TGTACA) and d(CGATCG) by Berger, Imre, Su, Li, Spitzner, Jeffrey R., Kang, ChulHee, Burke, Thomas G., Rich, Alexander

“…4′-Deoxy-4′-iododoxorubicln, a halogenated anthracycllne derivative, is an anticancer agent currently under Phase II clinical trials. In precllnlcal studies,…”
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