Synthesis of DNA by Micrococcus luteus is resistant to 6-(p-hydroxyphenylazo)uracil

The DNA synthesis inhibitor 6-(p-hydroxyphenylazo)uracil (HPUra), at concentrations ranging from 0.2 to 2000 micro M, had essentially no effect on DNA synthesis in Micrococcus luteus strain ML-1. Seven other M. luteus strains were unaffected by 200 micro M HPUra. In vitro DNA synthesis in toluene-tr...

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Bibliographic Details
Published in:	Canadian journal of microbiology Vol. 26; no. 5; p. 640
Main Authors:	Tittle, T V, Mayo, J A, Spitzer, W P
Format:	Journal Article
Language:	English
Published:	Canada 01-05-1980
Subjects:	Adenosine Triphosphate - pharmacology Deoxyribonucleotides - pharmacology Dithiothreitol - pharmacology DNA, Bacterial - biosynthesis Dose-Response Relationship, Drug Hydroxyphenylazouracil - pharmacology Magnesium - pharmacology Micrococcus - drug effects Micrococcus - metabolism Uracil - analogs & derivatives
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Summary:	The DNA synthesis inhibitor 6-(p-hydroxyphenylazo)uracil (HPUra), at concentrations ranging from 0.2 to 2000 micro M, had essentially no effect on DNA synthesis in Micrococcus luteus strain ML-1. Seven other M. luteus strains were unaffected by 200 micro M HPUra. In vitro DNA synthesis in toluene-treated M. luteus strain ML-1 ws resistant to both HPUra and reduced HPUra.
ISSN:	0008-4166
DOI:	10.1139/m80-112