Search Results - "Spitsin, Sergei V."

Therapeutic Intervention in Experimental Allergic Encephalomyelitis by Administration of Uric Acid Precursors by Scott, Gwen S., Spitsin, Sergei V., Kean, Rhonda B., Mikheeva, Tatiana, Koprowski, Hilary, Hooper, D. Craig

“…Uric acid (UA) is a purine metabolite that selectively inhibits peroxynitrite-mediated reactions implicated in the pathogenesis of multiple sclerosis (MS) and…”
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Comparison of uric acid and ascorbic acid in protection against EAE by Spitsin, Sergei V, Scott, Gwen S, Mikheeva, Tatiana, Zborek, Anna, Kean, Rhonda B, Brimer, Christine M, Koprowski, Hilary, Hooper, D.Craig

“…Serum levels of uric acid (UA), an inhibitor of peroxynitrite- (ONOO −) related chemical reactions, became elevated approximately 30 million years ago in…”
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Substance P enhances HIV-1 infection in human fetal brain cell cultures expressing full-length neurokinin-1 receptor by Schwartz, Lynnae, Spitsin, Sergei V., Meshki, John, Tuluc, Florin, Douglas, Steven D., Wolfe, John H.

“…The associations between the neurokinin-1 receptor (NK-1R), substance P (SP), and HIV-1 were investigated in neurosphere-derived cultures of…”
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The Peroxynitrite Scavenger Uric Acid Prevents Inflammatory Cell Invasion into the Central Nervous System in Experimental Allergic Encephalomyelitis through Maintenance of Blood-Central Nervous System Barrier Integrity by Kean, Rhonda B, Spitsin, Sergei V, Mikheeva, Tatiana, Scott, Gwen S, Hooper, D. Craig

“…Uric acid (UA), a product of purine metabolism, is a known scavenger of peroxynitrite (ONOO(-)), which has been implicated in the pathogenesis of multiple…”
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Activation of the Inducible Form of Nitric Oxide Synthase in the Brains of Patients with Multiple Sclerosis by Bagasra, O, Michaels, F H, Zheng, Y M, Bobroski, L E, Spitsin, S V, Fu, Z F, Tawadros, R, Koprowski, H

“…Nitric oxide (NO) has been implicated as a pathogenic mediator in a variety of central nervous system (CNS) disease states, including the animal model of…”
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The Central Nervous System Inflammatory Response to Neurotropic Virus Infection Is Peroxynitrite Dependent by Hooper, D. Craig, Kean, Rhonda B, Scott, Gwen S, Spitsin, Sergei V, Mikheeva, Tatiana, Morimoto, Kinjiro, Bette, Michael, Rohrenbeck, Annette M, Dietzschold, Bernhard, Weihe, Eberhard

“…We have recently demonstrated that increased blood-CNS barrier permeability and CNS inflammation in a conventional mouse model of experimental allergic…”
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ICAM-1 upregulation in the spinal cords of PLSJL mice with experimental allergic encephalomyelitis is dependent upon TNF-α production triggered by the loss of blood–brain barrier integrity by Scott, Gwen S., Kean, Rhonda B., Fabis, Marzena J., Mikheeva, Tatiana, Brimer, Christine M., Phares, Timothy W., Spitsin, Sergei V., Hooper, D.Craig

“…Urate (UA) selectively scavenges peroxynitrite-dependent radicals and suppresses CNS inflammation through effects that are manifested at the blood–brain…”
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Protection of myelin basic protein immunized mice from free-radical mediated inflammatory cell invasion of the central nervous system by the natural peroxynitrite scavenger uric acid by Spitsin, Sergei V, Scott, Gwen S, Kean, Rhonda B, Mikheeva, Tatiana, Hooper, D.Craig

“…Peroxynitrite (ONOO −), the product of nitric oxide (NO ) and superoxide (O 2 − ), is believed to be a major contributor to immunotoxicity when produced by…”
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Characterization and functional analysis of the human inducible nitric oxide synthase gene promoter by Spitsin, S V, Koprowski, H, Michaels, F H

“…Nitric oxide has a wide variety of homeostatic and pathological effects. Control of the production of nitric oxide by the inducible form of the enzyme resides…”
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Prospects for the treatment of multiple sclerosis by raising serum levels of uric acid, a scavenger of peroxynitrite by Koprowski, Hilary, Spitsin, Sergei V., Hooper, D. Craig

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Human- and mouse-inducible nitric oxide synthase promoters require activation of phosphatidylcholine-specific phospholipase C and NF-kappa B by Spitsin, S V, Farber, J L, Bertovich, M, Moehren, G, Koprowski, H, Michaels, F H

“…The production of nitric oxide by type II inducible nitric oxide synthase (type II NOS) gene is controlled at least in part by transcriptional activation…”
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