Search Results - "Spitschak, Alf"

Unraveling a tumor type-specific regulatory core underlying E2F1-mediated epithelial-mesenchymal transition to predict receptor protein signatures by Khan, Faiz M., Marquardt, Stephan, Gupta, Shailendra K., Knoll, Susanne, Schmitz, Ulf, Spitschak, Alf, Engelmann, David, Vera, Julio, Wolkenhauer, Olaf, Pützer, Brigitte M.

“…Cancer is a disease of subverted regulatory pathways. In this paper, we reconstruct the regulatory network around E2F, a family of transcription factors whose…”
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MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance by Lai, Xin, Gupta, Shailendra K, Schmitz, Ulf, Marquardt, Stephan, Knoll, Susanne, Spitschak, Alf, Wolkenhauer, Olaf, Pützer, Brigitte M, Vera, Julio

“…High rates of lethal outcome in tumour metastasis are associated with the acquisition of invasiveness and chemoresistance. Several clinical studies indicate…”
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E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune crosstalk that predicts T cell phenotype switching and therapeutic responsiveness by Spitschak, Alf, Dhar, Prabir, Singh, Krishna P., Garduño, Rosaely Casalegno, Gupta, Shailendra K., Vera, Julio, Musella, Luca, Murr, Nico, Stoll, Anja, Pützer, Brigitte M.

“…Melanoma is a metastatic, drug-refractory cancer with the ability to evade immunosurveillance. Cancer immune evasion involves interaction between tumor…”
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Drug Repurposing at the Interface of Melanoma Immunotherapy and Autoimmune Disease by Spitschak, Alf, Gupta, Shailendra, Singh, Krishna P, Logotheti, Stella, Pützer, Brigitte M

“…Cancer cells have a remarkable ability to evade recognition and destruction by the immune system. At the same time, cancer has been associated with chronic…”
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DNp73 Exerts Function in Metastasis Initiation by Disconnecting the Inhibitory Role of EPLIN on IGF1R-AKT/STAT3 Signaling by Steder, Marc, Alla, Vijay, Meier, Claudia, Spitschak, Alf, Pahnke, Jens, Fürst, Katharina, Kowtharapu, Bhavani S., Engelmann, David, Petigk, Janine, Egberts, Friederike, Schäd-Trcka, Susanne G., Gross, Gerd, Nettelbeck, Dirk M., Niemetz, Annett, Pützer, Brigitte M.

“…Dissemination of cancer cells from primary tumors is the key event in metastasis, but specific determinants are widely unknown. Here, we show that DNp73, an…”
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Rewiring E2F1 with classical NHEJ via APLF suppression promotes bladder cancer invasiveness by Richter, Christin, Marquardt, Stephan, Li, Fanghua, Spitschak, Alf, Murr, Nico, Edelhäuser, Berdien A H, Iliakis, George, Pützer, Brigitte M, Logotheti, Stella

“…Bladder cancer progression has been associated with dysfunctional repair of double-strand breaks (DSB), a deleterious type of DNA lesions that fuel genomic…”
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Mechanisms of Functional Pleiotropy of p73 in Cancer and Beyond by Logotheti, Stella, Richter, Christin, Murr, Nico, Spitschak, Alf, Marquardt, Stephan, Pützer, Brigitte M.

“…The transcription factor p73 is a structural and functional homolog of TP53, the most famous and frequently mutated tumor-suppressor gene. The TP73 gene can…”
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Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis by Marquardt, Stephan, Solanki, Manish, Spitschak, Alf, Vera, Julio, Pützer, Brigitte M.

“…Metastasis is one of the most challenging issues in cancer patient management, and effective therapies to specifically target disease progression are missing,…”
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Abstract 3092: Effect of cancer stem cell-specific progerin expression on metastatic potential by Morgenroth, Philipp, Söhnchen, Christoph, Spitschak, Alf, Puetzer, Brigitte M., Logotheti, Stella

“…Abstract Metastasis signals the final and treatment-refractory stage of cancer disease. Formation of metastases is fueled by a small cell subpopulation within…”
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MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit by Spitschak, Alf, Meier, Claudia, Kowtharapu, Bhavani, Engelmann, David, Pützer, Brigitte M

“…Dominant-activating mutations in the RET proto-oncogene, a receptor tyrosine kinase, are responsible for the development of medullary thyroid carcinoma (MTC)…”
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LncRNA-SLC16A1-AS1 induces metabolic reprogramming during Bladder Cancer progression as target and co-activator of E2F1 by Logotheti, Stella, Marquardt, Stephan, Gupta, Shailendra K., Richter, Christin, Edelhäuser, Berdien A.H., Engelmann, David, Brenmoehl, Julia, Söhnchen, Christoph, Murr, Nico, Alpers, Michael, Singh, Krishna P., Wolkenhauer, Olaf, Heckl, Dirk, Spitschak, Alf, Pützer, Brigitte M.

“…Long non-coding RNAs (lncRNAs) have emerged as integral components of E2F1-regulated gene regulatory networks (GRNs), but their implication in advanced or…”
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Novel integrated workflow allows production and in-depth quality assessment of multifactorial reprogrammed skeletal muscle cells from human stem cells by Faustino, Dinis, Brinkmeier, Heinrich, Logotheti, Stella, Jonitz-Heincke, Anika, Yilmaz, Hande, Takan, Isil, Peters, Kirsten, Bader, Rainer, Lang, Hermann, Pavlopoulou, Athanasia, Pützer, Brigitte M., Spitschak, Alf

“…Skeletal muscle tissue engineering aims at generating biological substitutes that restore, maintain or improve normal muscle function; however, the quality of…”
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Abstract 6814: E2F1-induced autocrine IL-6 inflammatory loop mediates cancer-immune cell crosstalk that regulates metastatic properties in melanoma by Dhar, Prabir, Singh, Krishna P., Gupta, Shailendra K., Peringot, Dhanya, Spitschak, Alf, Pützer, Brigitte M.

“…Abstract Melanoma is a cancer that is metastatic, drug-refractory and fatal if managed late or inadequately. The transcription factor E2F1 is a key player in…”
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Adenoviral mediated expression of anti-inflammatory progranulin by placental explants modulates endothelial cell activation by decrease of ICAM-1 expression by Stubert, Johannes, Szewczyk, Marlen, Spitschak, Alf, Knoll, Susanne, Richter, Dagmar-Ulrike, Pützer, Brigitte M.

“…Functional disorders of the villous trophoblast may result in preeclampsia through the release of endothelial activating substances. Progranulin is an…”
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Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures by Wang, Yajie, Alla, Vijay, Goody, Deborah, Gupta, Shailendra K, Spitschak, Alf, Wolkenhauer, Olaf, Pützer, Brigitte M, Engelmann, David

“…Transcription factor E2F1 is a key regulator of cell proliferation and apoptosis. Recently, it has been shown that aberrant E2F1 expression often detectable in…”
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DNp73-induced degradation of tyrosinase links depigmentation with EMT-driven melanoma progression by Fürst, Katharina, Steder, Marc, Logotheti, Stella, Angerilli, Alessandro, Spitschak, Alf, Marquardt, Stephan, Schumacher, Toni, Engelmann, David, Herchenröder, Ottmar, Rupp, Ralph A.W., Pützer, Brigitte M.

“…Melanoma is an aggressive cancer with poor prognosis, requiring personalized management of advanced stages and establishment of molecular markers. Melanomas…”
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Integrated Loss of miR-1/miR-101/miR-204 Discriminates Metastatic from Nonmetastatic Penile Carcinomas and Can Predict Patient Outcome by Hartz, Juliane M, Engelmann, David, Fürst, Katharina, Marquardt, Stephan, Spitschak, Alf, Goody, Deborah, Protzel, Chris, Hakenberg, Oliver W, Pützer, Brigitte M

“…Purpose Penile squamous cell carcinoma is a rare but aggressive cancer. Little is known about pivotal events in tumor pathogenesis and metastasis. Lymph node…”
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Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation by Casalegno‐Garduño, Rosaely, Schmitt, Anita, Spitschak, Alf, Greiner, Jochen, Wang, Lei, Hilgendorf, Inken, Hirt, Carsten, Ho, Anthony D., Freund, Mathias, Schmitt, Michael

“…Wilms' tumor gene 1 (WT1) is overexpressed in leukemia and WT1‐derived CD8+ T‐cell epitopes for immunotherapies targeting WT1 have been defined. Here, we…”
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Association of RHAMM with E2F1 promotes tumour cell extravasation by transcriptional up-regulation of fibronectin by Meier, Claudia, Spitschak, Alf, Abshagen, Kerstin, Gupta, Shailendra, Mor, Joel M., Wolkenhauer, Olaf, Haier, Jörg, Vollmar, Brigitte, Alla, Vijay, Pützer, Brigitte M.

“…Dissemination of cancer cells from primary to distant sites is a complex process; little is known about the genesis of metastatic changes during disease…”
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Abstract B26: Epigenetic master regulator EPC1 is a decisive factor for E2F1 to silence cell death and activate metastatic gene signatures in response to DNA damage by Engelmann, David, Wang, Yajie, Alla, Vijay, Goody, Deborah, Gupta, Shailendra K., Spitschak, Alf, Pützer, Brigitte M.

“…Abstract The transcription factor E2F1 is a key regulator of cell proliferation and apoptosis. Recently, it has been shown that aberrant E2F1 expression often…”
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