Search Results - "Spithill, Terry W."

Current Threat of Triclabendazole Resistance in Fasciola hepatica by Kelley, Jane M, Elliott, Timothy P, Beddoe, Travis, Anderson, Glenn, Skuce, Philip, Spithill, Terry W

“…Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola hepatica (liver fluke) but widespread resistance to the drug greatly…”
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A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance by Beesley, Nicola J, Cwiklinski, Krystyna, Allen, Katherine, Hoyle, Rebecca C, Spithill, Terry W, La Course, E James, Williams, Diana J L, Paterson, Steve, Hodgkinson, Jane E

“…Fasciola hepatica infection is responsible for substantial economic losses in livestock worldwide and poses a threat to human health in endemic areas. The…”
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Current Status for Controlling the Overlooked Caprine Fasciolosis by Zerna, Gemma, Spithill, Terry W, Beddoe, Travis

“…The disease fasciolosis is caused by the liver flukes and , which infect a wide range of mammals and production livestock, including goats. These flatworm…”
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Towards understanding the liver fluke transmission dynamics on farms: Detection of liver fluke transmitting snail and liver fluke-specific environmental DNA in water samples from an irrigated dairy farm in Southeast Australia by Rathinasamy, Vignesh, Tran, Lily, Swan, Jaclyn, Kelley, Jane, Hosking, Chris, Williamson, Genevieve, Knowles, Michaela, Elliott, Timothy, Rawlin, Grant, Spithill, Terry W, Beddoe, Travis

“…[Display omitted] •Treatment of Fasciola hepatica is problematic due to increasing drug resistance.•Alternative measures to lower exposure of livestock to…”
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Development of a multiplex quantitative PCR assay for detection and quantification of DNA from Fasciola hepatica and the intermediate snail host, Austropeplea tomentosa, in water samples by Rathinasamy, Vignesh, Hosking, Chris, Tran, Lily, Kelley, Jane, Williamson, Genevieve, Swan, Jaclyn, Elliott, Timothy, Rawlin, Grant, Beddoe, Travis, Spithill, Terry W.

“…[Display omitted] •Treatment of Fasciola hepatica is problematic due to increasing drug resistance.•Alternative measures to lower exposure of livestock to…”
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Stimulating Neoblast-Like Cell Proliferation in Juvenile Fasciola hepatica Supports Growth and Progression towards the Adult Phenotype In Vitro by McCusker, Paul, McVeigh, Paul, Rathinasamy, Vignesh, Toet, Hayley, McCammick, Erin, O'Connor, Anna, Marks, Nikki J, Mousley, Angela, Brennan, Gerard P, Halton, David W, Spithill, Terry W, Maule, Aaron G

“…Fascioliasis (or fasciolosis) is a socioeconomically important parasitic disease caused by liver flukes of the genus Fasciola. Flukicide resistance has exposed…”
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Evaluation of Immunogenicity and Efficacy of Fasciola hepatica Tetraspanin 2 (TSP2) Fused to E. coli Heat-Labile Enterotoxin B Subunit LTB Adjuvant Following Intranasal Vaccination of Cattle by Zerna, Gemma, Rathinasamy, Vignesh A., Toet, Hayley, Anderson, Glenn, Dempster, Robert, Spithill, Terry W., Beddoe, Travis

“…Fasciolosis, caused by the liver flukes Fasciola hepatica and F. gigantica, is an economically important and globally distributed zoonotic disease. Liver fluke…”
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Cathepsin B proteases of flukes: the key to facilitating parasite control? by Smooker, Peter M, Jayaraj, Rama, Pike, Robert N, Spithill, Terry W

“…Cysteine proteases are important virulence factors for parasites. This review will focus on the cathepsin B proteases of trematodes (also known as flukes)…”
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RNAi dynamics in Juvenile Fasciola spp. Liver flukes reveals the persistence of gene silencing in vitro by McVeigh, Paul, McCammick, Erin M, McCusker, Paul, Morphew, Russell M, Mousley, Angela, Abidi, Abbas, Saifullah, Khalid M, Muthusamy, Raman, Gopalakrishnan, Ravikumar, Spithill, Terry W, Dalton, John P, Brophy, Peter M, Marks, Nikki J, Maule, Aaron G

“…Fasciola spp. liver fluke cause pernicious disease in humans and animals. Whilst current control is unsustainable due to anthelmintic resistance, gene…”
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Bovine Natural Antibody Relationships to Specific Antibodies and Fasciola hepatica Burdens after Experimental Infection and Vaccination with Glutathione S -Transferase by Zerna, Gemma, Cameron, Timothy C, Toet, Hayley, Spithill, Terry W, Beddoe, Travis

“…is the causative agent of fasciolosis, a significant parasitic disease occurring worldwide. Despite ongoing efforts, there is still no vaccine to control liver…”
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Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens by Jayaraj, Ramamoorthi, Piedrafita, David, Dynon, Kemperley, Grams, Rudi, Spithill, Terry W., Smooker, Peter M.

“…Liver flukes produce cathepsin B and cathepsin L in their excretory–secretory material. These proteases are proposed to be key virulence factors for parasite…”
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Fasciola hepatica Control Practices on a Sample of Dairy Farms in Victoria, Australia by Kelley, Jane M., Rawlin, Grant, Beddoe, Travis, Stevenson, Mark, Spithill, Terry W.

“…In Australia, little is known about the strategies used by farmers to control Fasciola hepatica ( F. hepatica ) infection in dairy cattle…”
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Identification of Novel Diagnostic Serum Biomarkers for Chagas' Disease in Asymptomatic Subjects by Mass Spectrometric Profiling by Ndao, Momar, Spithill, Terry W, Caffrey, Rebecca, Li, Hongshan, Podust, Vladimir N, Perichon, Regis, Santamaria, Cynthia, Ache, Alberto, Duncan, Mark, Powell, Malcolm R, Ward, Brian J

“…More than 10 million people are thought to be infected with Trypanosoma cruzi, primarily in the Americas. The clinical manifestations of Chagas' disease (CD)…”
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Identification, expression and immunolocalization of cathepsin B3, a stage-specific antigen expressed by juvenile Fasciola gigantica by Sethadavit, Manussabhorn, Meemon, Krai, Jardim, Armando, Spithill, Terry W., Sobhon, Prasert

“…To identify antigens that could potentially be developed as vaccines against Fasciola gigantica, somatic antigens were analyzed by immunoprecipitation using…”
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Liver fluke vaccines in ruminants: strategies, progress and future opportunities by Toet, Hayley, Piedrafita, David M., Spithill, Terry W.

“…•The development of a vaccine for Fasciola spp. in livestock is a challenge.•Harnessing acquired immunity expressed by resistant livestock against fluke…”
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Chemical Attenuation of Plasmodium berghei Sporozoites Induces Sterile Immunity in Mice by Purcell, Lisa A, Yanow, Stephanie K, Lee, Moses, Spithill, Terry W, Rodriguez, Ana

“…Radiation and genetic attenuation of Plasmodium sporozoites are two approaches for whole-organism vaccines that protect against malaria. We evaluated chemical…”
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Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge by Purcell, Lisa A, Wong, Kurt A, Yanow, Stephanie K, Lee, Moses, Spithill, Terry W, Rodriguez, Ana

“…Abstract Vaccination with Plasmodium sporozoites attenuated by irradiation or genetic manipulation induces a protective immune response in rodent malaria…”
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Peritoneal Lavage Cells of Indonesian Thin-Tail Sheep Mediate Antibody-Dependent Superoxide Radical Cytotoxicity In Vitro against Newly Excysted Juvenile Fasciola gigantica but Not Juvenile Fasciola hepatica by Piedrafita, David, Estuningsih, Endah, Pleasance, Jill, Prowse, Rhoda, Raadsma, Herman W, Meeusen, Els N.T, Spithill, Terry W

“…Indonesian thin-tail (ITT) sheep resist infection by Fasciola gigantica by an immunological mechanism within 2 to 4 weeks of infection yet are susceptible to…”
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Potent Antimalarial and Transmission-Blocking Activities of Centanamycin, a Novel DNA-Binding Agent by Yanow, Stephanie K., Purcell, Lisa A., Pradel, Gabriele, Sato, Atsushi, Rodriguez, Ana, Lee, Moses, Spithill, Terry W.

“…Most treatments for malaria target the blood stage of infection in the human host, although few can also block transmission of the parasite to the mosquito. We…”
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Analysis of daily variation in the release of faecal eggs and coproantigen of Fasciola hepatica in naturally infected dairy cattle and the impact on diagnostic test sensitivity by Kelley, Jane M., Stevenson, Mark A., Rathinasamy, Vignesh, Rawlin, Grant, Beddoe, Travis, Spithill, Terry W.

“…•The liver fluke cELISA and Faecal Egg Counts (LFEC) were evaluated over 5 consecutive days in cows.•There was a 2.6–8.9 fold variation between days in the…”
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