Search Results - "Spira, ME"

Reversible transition of extracellular field potential recordings to intracellular recordings of action potentials generated by neurons grown on transistors by Cohen, Ariel, Shappir, Joseph, Yitzchaik, Shlomo, Spira, Micha E.

“…The employment of standard CMOS technology to produce semiconductor chips for recording neuronal activity or for its future use to link neurons and transistors…”
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Critical calpain-dependent ultrastructural alterations underlie the transformation of an axonal segment into a growth cone after axotomy of cultured Aplysia neurons by Spira, Micha E., Oren, Ruthi, Dormann, Ada, Gitler, Daniel

“…The transformation of a stable axonal segment into a motile growth cone is a critical step in the regeneration of amputated axons. In earlier studies we found…”
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Neurite retraction and regrowth regulated by membrane retrieval, membrane supply, and actin dynamics by Prager-Khoutorsky, Masha, Spira, Micha E

“…Abstract Structural remodeling of neurons occurs during development, regeneration, and in relation to learning and memory acquisition processes. These…”
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On-line confocal imaging of the events leading to structural dedifferentiation of an axonal segment into a growth cone after axotomy by Sahly, Iman, Khoutorsky, Arkady, Erez, Hadas, Prager-Khoutorsky, Masha, Spira, Micha E.

“…The transformation of a transected axonal tip into a growth cone (GC) after axotomy is a critical step in the cascade of events leading to regeneration…”
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Real time imaging of calcium-induced localized proteolytic activity after axotomy and its relation to growth cone formation by Gitler, D, Spira, M E

“…The emergence of a neuronal growth cone from a transected axon is a necessary step in the sequence of events that leads to successful regeneration. Yet, the…”
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Glutamate sensing with enzyme-modified floating-gate field effect transistors by Braeken, D., Rand, D.R., Andrei, A., Huys, R., Spira, M.E., Yitzchaik, S., Shappir, J., Borghs, G., Callewaert, G., Bartic, C.

“…Neurotransmitter release is the key factor of chemical messaging in the brain. Fast, sensitive and in situ detection of single cell neurotransmitter release is…”
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Calcium-Activated Proteases Are Critical for Refilling Depleted Vesicle Stores in Cultured Sensory-Motor Synapses of "Aplysia" by Khoutorsky, Arkady, Spira, Micha E

“…"Aplysia" motoneurons cocultured with a presynaptic sensory neuron exhibit homosynaptic depression when stimulated at low frequencies. A single bath…”
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Calcium concentration threshold and translocation kinetics of EGFP-DOC2B expressed in cultured Aplysia neurons by Malkinson, Guy, Spira, Micha E.

“…The double C2 domain protein family (DOC2) is characterized by two calcium-binding domains (C2). Upon binding to calcium, the affinity of the protein to…”
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Depletion type floating gate p-channel MOS transistor for recording action potentials generated by cultured neurons by Cohen, Ariel, Spira, Micha E, Yitshaik, Shlomo, Borghs, Gustaaf, Shwartzglass, Ofer, Shappir, Joseph

“…We report the realization of electrical coupling between neurons and depletion type floating gate (FG) p-channel MOS transistors. The devices were realized in…”
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Neurons culturing and biophotonic sensing using porous silicon by Ben-Tabou de Leon, S., Sa’ar, A., Oren, R., Spira, M. E., Yitzchaik, S.

“…We report on culturing of Aplysia neurons on porous silicon substrates. Good adhesion of the neurons to the porous silicon substrate and a formation of…”
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Localized and Transient Elevations of Intracellular Ca2+ Induce the Dedifferentiation of Axonal Segments into Growth Cones by Ziv, Noam E, Spira, Micha E

“…The formation of a growth cone at the tip of a severed axon is a key step in its successful regeneration. This process involves major structural and functional…”
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Calcium, protease activation, and cytoskeleton remodeling underlie growth cone formation and neuronal regeneration by Spira, M E, Oren, R, Dormann, A, Ilouz, N, Lev, S

“…The cytoarchitecture, synaptic connectivity, and physiological properties of neurons are determined during their development by the interactions between the…”
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Low mobility of the Ca2+ buffers in axons of cultured Aplysia neurons by Gabso, M, Neher, E, Spira, M E

“…Cellular Ca2+ buffers determine amplitude and diffusional spread of neuronal Ca2+ signals. Fixed Ca2+ buffers tend to retard the signal and to lower the…”
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Effective expression of the green fluorescent fusion proteins in cultured Aplysia neurons by Sahly, I, Erez, H, Khoutorsky, A, Shapira, E, Spira, Micha E

“…The green fluorescent fusion protein and its isoforms are extensively used to monitor gene expression, protein localisation and their dynamics in relations to…”
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Axotomy induces a transient and localized elevation of the free intracellular calcium concentration to the millimolar range by Ziv, N E, Spira, M E

“…1. Axonal transection triggers a cascade of pathological processes that frequently lead to the degeneration of the injured neuron. It is generally believed…”
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Porous silicon substrates for neurons culturing and bio-photonic sensing by de-Leon, S. Ben-Tabou, Oren, R., Spira, M. E., Korbakov, N., Yitzchaik, S., Sa'ar, A.

“…In this work we report on culturing of Aplysia neurons and vertebrate cells to porous silicon substrates and on the first steps toward characterizing porous…”
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A New Family of Conotoxins That Blocks Voltage-gated Sodium Channels (∗) by McIntosh, J. Michael, Hasson, Arik, Spira, Micha E., Gray, William R., Li, Wenqin, Marsh, Maren, Hillyard, David R., Olivera, Baldomero M.

“…Conus peptides, including ω-conotoxins and α-conotoxins (targeting calcium channels and nicotinic acetylcholine receptors, respectively) have been useful…”
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New Mollusk-Specific .alpha.-Conotoxins Block Aplysia Neuronal Acetylcholine Receptors by Fainzilber, Michael, Hasson, Arik, Oren, Ruth, Burlingame, Alma L, Gordon, Dalia, Spira, Micha E, Zlotkin, Eliahu

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Electrically conductive 2D-PAN-containing surfaces as a culturing substrate for neurons by Oren, R., Sfez, R., Korbakov, N., Shabtai, K., Cohen, A., Erez, H., Dormann, A., Cohen, H., Shappir, J., Spira, M.E., Yitzchaik, S.

“…In the present contribution we report on a novel route to synthesize 2D-polyaniline (2DPAN) on sulfonated-poly(styrene) (SPS) templates by allowing first…”
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Simultaneous measurement of intracellular Ca2+ and asynchronous transmitter release from the same crayfish bouton by Ravin, R., Spira, M. E., Parnas, H., Parnas, I.

“…1. A technique has been developed to monitor neurotransmitter release simultaneously with intracellular Ca2+ concentration ([Ca2+]i) in single release boutons…”
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