Search Results - "Spinosa, Michael D"

Endothelial pannexin-1 channels modulate macrophage and smooth muscle cell activation in abdominal aortic aneurysm formation by Filiberto, Amanda C., Spinosa, Michael D., Elder, Craig T., Su, Gang, Leroy, Victoria, Ladd, Zachary, Lu, Guanyi, Mehaffey, J. Hunter, Salmon, Morgan D., Hawkins, Robert B., Ravichandran, Kodi S., Isakson, Brant E., Upchurch, Gilbert R., Sharma, Ashish K.

“…Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases…”
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Tightrope Technique for facilitating complex endovascular aortic repair in patients with severely angulated neck by Spinosa, Michael D., Adams, Joshua D.

“…An 84-year-old presented with a large, symptomatic juxtarenal abdominal aortic aneurysm. Owing to severe angulation of the infrarenal neck, advancement of the…”
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B Cell–Activating Factor Antagonism Attenuates the Growth of Experimental Abdominal Aortic Aneurysm by Spinosa, Michael D., Montgomery, William G., Lempicki, Melissa, Srikakulapu, Prasad, Johnsrude, Matthew J., McNamara, Coleen A., Upchurch, Gilbert R., Ailawadi, Gorav, Leitinger, Norbert, Meher, Akshaya K.

“…B cell–activating factor (BAFF), part of a tumor necrosis factor family of cytokines, was recently identified as a regulator of atherosclerosis; however, its…”
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A novel swine model of abdominal aortic aneurysm by Cullen, J. Michael, Lu, Guanyi, Shannon, Alexander H., Su, Gang, Sharma, Ashish, Salmon, Morgan, Fashandi, Anna Z., Spinosa, Michael D., Montgomery, William G., Johnston, W. Forrest, Ailawadi, Gorav, Upchurch, Gilbert R.

“…Few large-animal models exist for the study of aortic aneurysms. β-Aminopropionitrile (BAPN) is a compound known to cause aortic aneurysms by inhibiting lysyl…”
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Single-Photon Emission Computed Tomography Imaging Using Formyl Peptide Receptor 1 Ligand Can Diagnose Aortic Aneurysms in a Mouse Model by Shannon, Alexander H., Chordia, Mahendra D., Spinosa, Michael D., Su, Gang, Ladd, Zachary, Pan, Dongfeng, Upchurch, Gilbert R., Sharma, Ashish K.

“…Our previous studies showed that neutrophil infiltration and activation plays an important role in the pathogenesis of abdominal aortic aneurysms (AAA)…”
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Pharmacologic inhibition of transient receptor channel vanilloid 4 attenuates abdominal aortic aneurysm formation by Shannon, Alexander H., Elder, Craig T., Lu, Guanyi, Su, Gang, Mast, Alexis, Salmon, Morgan D., Montgomery, William G., Spinosa, Michael D., Upchurch, Gilbert R., Sharma, Ashish K.

“…Abdominal aortic aneurysm (AAA) formation is characterized by inflammation, leukocyte infiltration, and vascular remodeling. This study investigates the role…”
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A novel reproducible model of aortic aneurysm rupture by Fashandi, Anna Z., Hawkins, Robert B., Salmon, Morgan D., Spinosa, Michael D., Montgomery, William G., Cullen, J. Michael, Lu, Guanyi, Su, Gang, Ailawadi, Gorav, Upchurch, Gilbert R.

“…Given the unknown biologic antecedents before aortic aneurysm rupture, the purpose of this study was to establish a reproducible model of aortic aneurysm…”
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Sex-Based Differences Among Experimental Swine Abdominal Aortic aneurysms by Cullen, J. Michael, Shannon, Alexander H., Lu, Guanyi, Su, Gang, Spinosa, Michael D., Montgomery, William G., Ailawadi, Gorav, Salmon, Morgan, Upchurch, Gilbert R.

“…Female sex protects against abdominal aortic aneurysms (AAAs); however, the mechanisms behind these sex-based differences remain unknown. The purpose of this…”
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Tamsulosin attenuates abdominal aortic aneurysm growth by Montgomery, William G., Spinosa, Michael D., Cullen, J. Michael, Salmon, Morgan D., Su, Gang, Hassinger, Taryn, Sharma, Ashish K., Lu, Guanyi, Fashandi, Anna, Ailawadi, Gorav, Upchurch, Gilbert R.

“…Tamsulosin, an α1A-adrenergic receptor inhibitor, is prescribed to treat benign prostatic hyperplasia in men >60 years of age, the same demographic most…”
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Porcine Model of Infrarenal Abdominal Aortic Aneurysm by Shannon, Alexander H, Cullen, J Michael, Dahl, Jolian J, Scott, Erik J, Tyerman, Zachary, Spinosa, Michael D, Montgomery, William G, Johnston, W Forrest, Lu, Guanyi, Salmon, Morgan, Ailawadi, Gorav, Upchurch, Jr, Gilbert R

“…Large animal models to study abdominal aortic aneurysms are sparse. The purpose of this model is to create reproducible, clinically significant infrarenal…”
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SPECT imaging using formyl peptide receptor 1 ligand can diagnose aortic aneurysms in a mouse model by Shannon, Alexander H., Chordia, Mahendra D., Spinosa, Michael D., Su, Gang, Ladd, Zachary, Pan, Dongfeng, Upchurch, Gilbert R., Sharma, Ashish K.

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Abstract 436: Smooth Muscle Specific Knock-out of the Zinc-Finger Protein 148(ZFP148) Attenuates Atherosclerotic Lesion Formation via Regulation of Apoptotic Signaling Pathways by Salmon, Morgan, Fashandi, Anna Z, Spinosa, Michael D, Sharma, Ashish K, Owens, Gary K, Merchant, Juanita L, Zehner, Zendra E, Upchurch, Gilbert R, Ailawadi, Gorav

“…Abstract only Objective: Zinc-finger protein 148 (ZFP148) plays a profound role in the modulation of aortic aneurysm formation in part via modulation of smooth…”
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Abstract 12314: Pharmacologic Inhibition of Transient Receptor Channel Vanilloid 4 Attenuates Aortic Aneurysm Formation by Shannon, Alexander H, Montgomery, William, Salmon, Morgan, Spinosa, Michael D, Cullen, J Michael, Tyerman, Zachary, Ailawadi, Gorav, Upchurch, Gilbert R, Sharma, Ashish K

“…IntroductionCurrently, there are no pharmacologic therapeutic modalities for decreasing aortic aneurysm growth. Recent reports suggest that vanilloid subfamily…”
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