Search Results - "Spinner, Daryl S."
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Health Technology Assessment for Molecular Diagnostics: Practices, Challenges, and Recommendations from the Medical Devices and Diagnostics Special Interest Group
Published in Value in health (01-07-2016)“…Abstract Background Health technology assessments (HTAs) are increasingly used to inform coverage, access, and utilization of medical technologies including…”
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Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology
Published in The Journal of neuroscience (11-02-2009)“…The pathogenesis of Alzheimer's disease (AD) is thought to be related to the accumulation of amyloid beta (Abeta) in amyloid deposits and toxic oligomeric…”
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Progress toward Health System Readiness for Genome-Based Testing in Canada
Published in Current oncology (Toronto) (01-06-2023)“…(1) Background: Genomic medicine harbors the real potential to improve the health and healthcare journey of patients, care provider experiences, and improve…”
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Effective and Efficient Delivery of Genome-Based Testing-What Conditions Are Necessary for Health System Readiness?
Published in Healthcare (Basel) (01-10-2022)“…Health systems internationally must prepare for a future of genetic/genomic testing to inform healthcare decision-making while creating research opportunities…”
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Clearance and prevention of prion infection in cell culture by anti-PrP antibodies
Published in The European journal of neuroscience (01-05-2006)“…Prion diseases are transmissible and invariably fatal neurodegenerative disorders associated with a conformational transformation of the cellular prion protein…”
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Anti-PrP Mab 6D11 suppresses PrPSc replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo
Published in Neurobiology of disease (01-05-2009)“…Abstract The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrPC ) into a toxic, infectious, and…”
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Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice
Published in Journal of Virology (01-11-2008)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Are Global Health Systems Ready for Transformative Therapies?
Published in Value in health (01-06-2019)“…We have seen significant advancement in a range of health technologies, some with transformative or curative potential. Nevertheless, it is often unclear how…”
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CpG oligodeoxynucleotide-enhanced humoral immune response and production of antibodies to prion protein PrPSc in mice immunized with 139A scrapie-associated fibrils
Published in Journal of leukocyte biology (01-06-2007)“…Prion diseases are characterized by conversion of the cellular prion protein (PrPC) to a protease‐resistant conformer, the srapie form of PrP (PrPSc). Humoral…”
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Regenerative Medicine and Cell Therapy in Orthopedics—Health Policy, Regulatory and Clinical Development, and Market Access
Published in Techniques in orthopaedics (Rockville, Md.) (01-12-2019)“…Orthopedic indications collectively represent a large clinical and economic burden, especially given the aging world population. To meet this area of unmet…”
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Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo
Published in Neurobiology of disease (01-05-2009)“…The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrP(C)) into a toxic, infectious, and…”
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Inflammatory mediators are inhibited by a taurine metabolite in CpG oligodeoxynucleotide and IFN-r activated macrophage cell line
Published in Journal of drugs in dermatology (01-05-2013)“…Taurine plays an important role in brain and retinal development, and has an antiinflammatory and antioxidant function. Taurine chloramine (Tau-Cl) is produced…”
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Altered lymphocyte proliferation and innate immune function in scrapie 139A- and ME7-infected mice
Published in Viral immunology (01-06-2013)“…Lymphoid organs play an important role in prion disease development and progression. While the role of lymphoid organs and changes in immune-related genes have…”
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Do different clinical evidence bases lead to discordant health-technology assessment decisions? An in-depth case series across three jurisdictions
Published in ClinicoEconomics and outcomes research (01-01-2013)“…Health-technology assessment (HTA) plays an important role in informing drug-reimbursement decision-making in many countries. HTA processes for the…”
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Stimulation of innate immunity via Toll-like receptor 9 mitigates Alzheimer pathology
Published in Alzheimer's & dementia (01-07-2010)Get full text
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A sensitive and quantitative assay for normal PrP in plasma
Published in Journal of virological methods (01-05-2008)“…Transmissible spongiform encephalopathies can be transmitted by blood transfusion. The risk of spreading the disease among the human population could be…”
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Toll-like receptor 9 ligand CpG ODN as a new highly effective agent for prevention and/or treatment of Alzheimer's disease
Published in Alzheimer's & dementia (01-07-2009)Get full text
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P2-405: Induction of toll-like receptor 9 signaling as a method for preventing or ameliorating Alzheimer's disease
Published in Alzheimer's & dementia (01-07-2008)Get full text
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P2-212: Suppression of PrPSc replication in follicular dendritic cells in vitro and in vivo by therapeutic 6D11 monoclonal antibody
Published in Alzheimer's & dementia (01-07-2008)Get full text
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Interaction of the myogenic determination factor myogenin with E12 and a DNA target: mechanism and kinetics
Published in Journal of molecular biology (29-03-2002)“…The myogenic determination factors MyoD, myogenin, myf5, and MRF4 are members of the basic helix-loop-helix (bHLH) family of transcription factors and crucial…”
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