Search Results - "Spinner, Daryl S."

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    Induction of Toll-Like Receptor 9 Signaling as a Method for Ameliorating Alzheimer's Disease-Related Pathology by Scholtzova, Henrieta, Kascsak, Richard J, Bates, Kristyn A, Boutajangout, Allal, Kerr, Daniel J, Meeker, Harry C, Mehta, Pankaj D, Spinner, Daryl S, Wisniewski, Thomas

    Published in The Journal of neuroscience (11-02-2009)
    “…The pathogenesis of Alzheimer's disease (AD) is thought to be related to the accumulation of amyloid beta (Abeta) in amyloid deposits and toxic oligomeric…”
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    Progress toward Health System Readiness for Genome-Based Testing in Canada by Husereau, Don, Villalba, Eva, Muthu, Vivek, Mengel, Michael, Ivany, Craig, Steuten, Lotte, Spinner, Daryl S, Sheffield, Brandon, Yip, Stephen, Jacobs, Philip, Sullivan, Terrence, Arshoff, Larry

    Published in Current oncology (Toronto) (01-06-2023)
    “…(1) Background: Genomic medicine harbors the real potential to improve the health and healthcare journey of patients, care provider experiences, and improve…”
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    Effective and Efficient Delivery of Genome-Based Testing-What Conditions Are Necessary for Health System Readiness? by Husereau, Don, Steuten, Lotte, Muthu, Vivek, Thomas, David M, Spinner, Daryl S, Ivany, Craig, Mengel, Michael, Sheffield, Brandon, Yip, Stephen, Jacobs, Philip, Sullivan, Terrence

    Published in Healthcare (Basel) (01-10-2022)
    “…Health systems internationally must prepare for a future of genetic/genomic testing to inform healthcare decision-making while creating research opportunities…”
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    Clearance and prevention of prion infection in cell culture by anti-PrP antibodies by Pankiewicz, Joanna, Prelli, Frances, Sy, Man-Sun, Kascsak, Richard J., Kascsak, Regina B., Spinner, Daryl S., Carp, Richard I., Meeker, Harry C., Sadowski, Marcin, Wisniewski, Thomas

    Published in The European journal of neuroscience (01-05-2006)
    “…Prion diseases are transmissible and invariably fatal neurodegenerative disorders associated with a conformational transformation of the cellular prion protein…”
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    Anti-PrP Mab 6D11 suppresses PrPSc replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo by Sadowski, Martin J, Pankiewicz, Joanna, Prelli, Frances, Scholtzova, Henrieta, Spinner, Daryl S, Kascsak, Regina B, Kascsak, Richard J, Wisniewski, Thomas

    Published in Neurobiology of disease (01-05-2009)
    “…Abstract The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrPC ) into a toxic, infectious, and…”
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    Are Global Health Systems Ready for Transformative Therapies? by Faulkner, Eric, Spinner, Daryl S., Ringo, Moira, Carroll, Marissa

    Published in Value in health (01-06-2019)
    “…We have seen significant advancement in a range of health technologies, some with transformative or curative potential. Nevertheless, it is often unclear how…”
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    Regenerative Medicine and Cell Therapy in Orthopedics—Health Policy, Regulatory and Clinical Development, and Market Access by Spinner, Daryl S, Faulkner, Eric C, Carroll, Marissa C, Ringo, Moira C, Joines, John W

    “…Orthopedic indications collectively represent a large clinical and economic burden, especially given the aging world population. To meet this area of unmet…”
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    Anti-PrP Mab 6D11 suppresses PrP(Sc) replication in prion infected myeloid precursor line FDC-P1/22L and in the lymphoreticular system in vivo by Sadowski, Martin J, Pankiewicz, Joanna, Prelli, Frances, Scholtzova, Henrieta, Spinner, Daryl S, Kascsak, Regina B, Kascsak, Richard J, Wisniewski, Thomas

    Published in Neurobiology of disease (01-05-2009)
    “…The pathogenesis of prion diseases is related to conformational transformation of cellular prion protein (PrP(C)) into a toxic, infectious, and…”
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    Inflammatory mediators are inhibited by a taurine metabolite in CpG oligodeoxynucleotide and IFN-r activated macrophage cell line by Kim, Bo Sook, Spinner, Daryl S, Kascsak, Richard J, Park, Seung Yong, Cho, In Soo, Schuller-Levis, Georgia, Park, Eunkyue

    Published in Journal of drugs in dermatology (01-05-2013)
    “…Taurine plays an important role in brain and retinal development, and has an antiinflammatory and antioxidant function. Taurine chloramine (Tau-Cl) is produced…”
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    Altered lymphocyte proliferation and innate immune function in scrapie 139A- and ME7-infected mice by Cho, In Soo, Spinner, Daryl S, Kascsak, Richard J, Meeker, H Cliff, Kim, Bo Sook, Park, Seung Yong, Schuller-Levis, Georgia, Park, Eunkyue

    Published in Viral immunology (01-06-2013)
    “…Lymphoid organs play an important role in prion disease development and progression. While the role of lymphoid organs and changes in immune-related genes have…”
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    Do different clinical evidence bases lead to discordant health-technology assessment decisions? An in-depth case series across three jurisdictions by Spinner, Daryl S, Birt, Julie, Walter, Jeffrey W, Bowman, Lee, Mauskopf, Josephine, Drummond, Michael F, Copley-Merriman, Catherine

    Published in ClinicoEconomics and outcomes research (01-01-2013)
    “…Health-technology assessment (HTA) plays an important role in informing drug-reimbursement decision-making in many countries. HTA processes for the…”
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    A sensitive and quantitative assay for normal PrP in plasma by Gregori, Luisa, Gray, Benjamin N., Rose, Elaine, Spinner, Daryl S., Kascsak, Richard J., Rohwer, Robert G.

    Published in Journal of virological methods (01-05-2008)
    “…Transmissible spongiform encephalopathies can be transmitted by blood transfusion. The risk of spreading the disease among the human population could be…”
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    Interaction of the myogenic determination factor myogenin with E12 and a DNA target: mechanism and kinetics by Spinner, Daryl S, Liu, Shaohua, Wang, Shao-Wen, Schmidt, Jakob

    Published in Journal of molecular biology (29-03-2002)
    “…The myogenic determination factors MyoD, myogenin, myf5, and MRF4 are members of the basic helix-loop-helix (bHLH) family of transcription factors and crucial…”
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