Search Results - "Spinka, Michael"

Arabidopsis thaliana PECP1 — Enzymatic characterization and structural organization of the first plant phosphoethanolamine/phosphocholine phosphatase by May, Anett, Spinka, Michael, Köck, Margret

“…Maintenance of cellular phosphate homeostasis is crucial for primary and energy metabolism. In plants, low exogenous phosphate availability activates adaptive…”
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Significance of Individual Residues at the Regulatory Site of Yeast Pyruvate Decarboxylase for Allosteric Substrate Activation by Spinka, Michael, Seiferheld, Sebastian, Zimmermann, Philipp, Bergner, Elena, Blume, Anne-Kathrin, Schierhorn, Angelika, Reichenbach, Tom, Pertermann, Robert, Ehrt, Christiane, König, Stephan

“…The catalytic activity of the allosteric enzyme pyruvate decarboxylase from yeast is strictly controlled by its own substrate pyruvate via covalent binding at…”
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Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation by Kutter, Steffen, Weiss, Manfred S., Wille, Georg, Golbik, Ralph, Spinka, Michael, König, Stephan

“…The mechanism by which the enzyme pyruvate decarboxylase from two yeast species is activated allosterically has been elucidated. A total of seven…”
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Activation of Thiamin Diphosphate and FAD in the Phosphatedependent Pyruvate Oxidase fromLactobacillus plantarum by Tittmann, Kai, Proske, Daniela, Spinka, Michael, Ghisla, Sandro, Rudolph, Rainer, Hübner, Gerhard, Kern, Gunther

“…The phosphate- and oxygen-dependent pyruvate oxidase from Lactobacillus plantarum is a homotetrameric enzyme that binds 1 FAD and 1 thiamine diphosphate per…”
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Phosphorylation of Serine 264 Impedes Active Site Accessibility in the E1 Component of the Human Pyruvate Dehydrogenase Multienzyme Complex by Seifert, Franziska, Ciszak, Ewa, Korotchkina, Lioubov, Golbik, Ralph, Spinka, Michael, Dominiak, Paulina, Sidhu, Sukhdeep, Brauer, Johanna, Patel, Mulchand S, Tittmann, Kai

“…At the junction of glycolysis and the Krebs cycle in cellular metabolism, the pyruvate dehydrogenase multienzyme complex (PDHc) catalyzes the oxidative…”
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Allosteric activation of pyruvate decarboxylases. A never-ending story? by König, Stephan, Spinka, Michael, Kutter, Steffen

“…The allosteric substrate activation of pyruvate decarboxylases was studied for more than 30 years using varying techniques and ending up in different…”
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Catalytically active filaments – pyruvate decarboxylase from Neurospora crassa. pH‐controlled oligomer structure and catalytic function by Hüttl, Stefanie, Fiebig, Juliane, Kutter, Steffen, Hause, Gerd, Lilie, Hauke, Spinka, Michael, König, Stephan

“…Pyruvate decarboxylase is a key enzyme in organisms whose energy metabolism is based on alcoholic fermentation. The enzyme catalyses the nonoxidative…”
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Catalytically active filaments - pyruvate decarboxylase from Neurosporacrassa. pH-controlled oligomer structure and catalytic function by Hüttl, Stefanie, Fiebig, Juliane, Kutter, Steffen, Hause, Gerd, Lilie, Hauke, Spinka, Michael, König, Stephan

“…Pyruvate decarboxylase is a key enzyme in organisms whose energy metabolism is based on alcoholic fermentation. The enzyme catalyses the nonoxidative…”
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Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme ActivationS by Kutter, Steffen, Weiss, Manfred S., Wille, Georg, Golbik, Ralph, Spinka, Michael, König, Stephan

“…The mechanism by which the enzyme pyruvate decarboxylase from two yeast species is activated allosterically has been elucidated. A total of seven…”
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Amino Acids Allosterically Regulate the Thiamine Diphosphate-dependent α-Keto Acid Decarboxylase from Mycobacterium tuberculosis by Werther, Tobias, Spinka, Michael, Tittmann, Kai, Schütz, Anja, Golbik, Ralph, Mrestani-Klaus, Carmen, Hübner, Gerhard, König, Stephan

“…The gene rv0853c from Mycobacterium tuberculosis strain H37Rv codes for a thiamine diphosphate-dependent α-keto acid decarboxylase (MtKDC), an enzyme involved…”
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Amino Acids Allosterically Regulate the Thiamine Diphosphate-dependent α-Keto Acid Decarboxylase from Mycobacterium tuberculosis by Tobias Werther, Michael Spinka, Kai Tittmann, Anja Schütz, Ralph Golbik, Carmen Mrestani-Klaus, Gerhard Hübner, Stephan König

“…The gene rv0853c from Mycobacterium tuberculosis strain H37Rv codes for a thiamine diphosphate-dependent α-keto acid decarboxylase ( Mt KDC), an enzyme…”
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The influence of protein concentration on oligomer structure and catalytic function of two pyruvate decarboxylases by Kutter, Steffen, Spinka, Michael, Koch, Michel H J, König, Stephan

“…As a general rule protein concentration typical for structural studies differs considerably from that chosen for kinetic investigations. Consequently,…”
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Consequences of a Modified Putative Substrate-Activation Site on Catalysis by Yeast Pyruvate Decarboxylase by Wang, Jue, Golbik, Ralph, Seliger, Birgitta, Spinka, Michael, Tittmann, Kai, Hübner, Gerhard, Jordan, Frank

“…Earlier, it had been proposed in the laboratories at Halle that a cysteine residue is responsible for the hysteretic substrate activation behavior of yeast…”
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Activation of Thiamin Diphosphate and FAD in the Phosphate-dependent Pyruvate Oxidase from Lactobacillus plantarum by Tittmann, K, Proske, D, Spinka, M, Ghisla, S, Rudolph, R, Huebner, G, Kern, G

“…The phosphate- and oxygen-dependent pyruvate oxidase from Lactobacillus plantarum is a homotetrameric enzyme that binds 1 FAD and 1 thiamine diphosphate per…”
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Pyruvate decarboxylase from Kluyveromyces lactis. An enzyme with an extraordinary substrate activation behaviour by Krieger, Florian, Spinka, Michael, Golbik, Ralph, Hübner, Gerhard, König, Stephan

“…Pyruvate decarboxylase (EC 4.1.1.1) was isolated and purified from the yeast Kluyveromyces lactis. The properties of this enzyme relating to the native…”
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Molecular Mechanism of Regulation of the Pyruvate Dehydrogenase Complex from E. coli by Hennig, Jana, Kern, Gunther, Neef, Holger, Spinka, Michael, Bisswanger, Hans, Hübner, Gerhard

“…The pyruvate dehydrogenase multienzyme complex from E. coli shows a sigmoidal dependency of the reaction rate on the substrate concentration when product…”
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Pyruvate decarboxylase from Kluyveromyces lactis by Krieger, Florian, Spinka, Michael, Golbik, Ralph, Hübner, Gerhard, König, Stephan

“…Pyruvate decarboxylase (EC 4.1.1.1) was isolated and purified from the yeast Kluyveromyces lactis. The properties of this enzyme relating to the native…”
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Activation of thiamin diphosphate in enzymes by Hübner, Gerhard, Tittmann, Kai, Killenberg-Jabs, Margrit, Schäffner, Jörg, Spinka, Michael, Neef, Holger, Kern, Dorothee, Kern, Gunther, Schneider, Gunter, Wikner, Christer, Ghisla, Sandro

“…Activation of the coenzyme ThDP was studied by measuring the kinetics of deprotonation at the C2 carbon of thiamin diphosphate in the enzymes pyruvate…”
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