Search Results - "Spink, G"

Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA by Togneri, Fiona S, Ward, Douglas G, Foster, Joseph M, Devall, Adam J, Wojtowicz, Paula, Alyas, Sofia, Vasques, Fabiana Ramos, Oumie, Assa, James, Nicholas D, Cheng, K K, Zeegers, Maurice P, Deshmukh, Nayneeta, O'Sullivan, Brendan, Taniere, Philippe, Spink, Karen G, McMullan, Dominic J, Griffiths, Mike, Bryan, Richard T

“…Urothelial bladder cancers (UBCs) have heterogeneous clinical characteristics that are mirrored in their diverse genomic profiles. Genomic profiling of UBCs…”
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Cranio-cervical junction malformation causing cord compression in infant with achondroplasia: a bigger picture by Caratella, S, Tarazi, M, Tomalieh, F T, Spink, G, Bukhari, S U A, Ahmad, I H, Hussain, M M

“…Achondroplasia is a genetic disorder known for short stature and skeletal abnormalities. We present a case of narrowing of the foramen magnum from a large…”
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Quantum Monte Carlo study of the three-dimensional spin-polarized homogeneous electron gas by Spink, G. G., Needs, R. J., Drummond, N. D.

“…We have studied the spin-polarized three-dimensional homogeneous electron gas using the diffusion quantum Monte Carlo method, with trial wave functions…”
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Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense by Moschos, Sterghios A, Frick, Manfred, Taylor, Bruce, Turnpenny, Paul, Graves, Helen, Spink, Karen G, Brady, Kevin, Lamb, David, Collins, David, Rockel, Thomas D, Weber, Markus, Lazari, Ovadia, Perez-Tosar, Luis, Fancy, Sally A, Lapthorn, Chris, Green, Martin X, Evans, Steve, Selby, Matthew, Jones, Gareth, Jones, Lyn, Kearney, Sarah, Mechiche, Houria, Gikunju, Diana, Subramanian, Romesh, Uhlmann, Eugen, Jurk, Marion, Vollmer, Jörg, Ciaramella, Giuseppe, Yeadon, Michael

“…Antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) promise specific correction of disease-causing gene expression. Therapeutic implementation,…”
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Improved expression of secreted and membrane-targeted proteins in insect cells by Hitchman, Richard B., Possee, Robert D., Siaterli, Evangelia, Richards, Kevin S., Clayton, Amber J., Bird, Louise E., Owens, Raymond J., Carpentier, David C. J., King, Fiona L., Danquah, John O., Spink, Karen G., King, Linda A.

“…Secretory and membrane‐bound proteins are generally produced in lower amounts in insect cells compared with cytoplasmic and nuclear proteins. There may be many…”
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HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer trials by Richman, Susan D, Southward, Katie, Chambers, Philip, Cross, Debra, Barrett, Jennifer, Hemmings, Gemma, Taylor, Morag, Wood, Henry, Hutchins, Gordon, Foster, Joseph M, Oumie, Assa, Spink, Karen G, Brown, Sarah R, Jones, Marc, Kerr, David, Handley, Kelly, Gray, Richard, Seymour, Matthew, Quirke, Philip

“…HER2 overexpression/amplification is linked to trastuzumab response in breast/gastric cancers. One suggested anti‐EGFR resistance mechanism in colorectal…”
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The RAD51 Family Member, RAD51L3, Is a DNA-stimulated ATPase That Forms a Complex with XRCC2 by Braybrooke, J P, Spink, K G, Thacker, J, Hickson, I D

“…The Rad51 protein in eukaryotic cells is a structural and functional homolog of Escherichia coli RecA with a role in DNA repair and genetic recombination…”
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Sequence-specific binding of Taz1p dimers to fission yeast telomeric DNA by Spink, K.G, Evans, R.J, Chambers, A

“…The fission yeast (Schizosaccharomyces pombe) taz1 gene encodes a telomere-associated protein. It contains a single copy of a Myb-like motif termed the telobox…”
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Phosphodiesterase type 4 expression and anti-proliferative effects in human pulmonary artery smooth muscle cells by Growcott, Ellena J, Spink, Karen G, Ren, Xiaohui, Afzal, Saliha, Banner, Kathy H, Wharton, John

“…Pulmonary arterial hypertension is a proliferative vascular disease, characterized by aberrant regulation of smooth muscle cell proliferation and apoptosis in…”
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Relevance of systems pharmacology in drug discovery by Cucurull-Sanchez, Lourdes, Spink, Karen G., Moschos, Sterghios Athanasios

“…The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we…”
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Effects of induced aniseikonia on binocular visual acuity by Seddon, Annabelle, Chaki, Hanna M, Phan, Hang-My JD, Spink, Jessica G, Ha, Matthew LP, Wijesuriya, Surini, Atchison, David A, Carkeet, Andrew

“…Binocular visual acuity is an important index of functional performance. Optometrists need to know how binocular visual acuity is affected by aniseikonia, and…”
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Cross-laboratory validation of the OncoScan® FFPE Assay, a multiplex tool for whole genome tumour profiling by Foster, Joseph M, Oumie, Assa, Togneri, Fiona S, Vasques, Fabiana Ramos, Hau, Debra, Taylor, Morag, Tinkler-Hundal, Emma, Southward, Katie, Medlow, Paul, McGreeghan-Crosby, Keith, Halfpenny, Iris, McMullan, Dominic J, Quirke, Phil, Keating, Katherine E, Griffiths, Mike, Spink, Karen G, Brew, Fiona

“…Adoption of new technology in both basic research and clinical settings requires rigorous validation of analytical performance. The OncoScan® FFPE Assay is a…”
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In Vivo Analysis of Functional Regions within Yeast Rap1p by Graham, Ian R., Haw, Robin A., Spink, Karen G., Halden, Kathryn A., Chambers, Alistair

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The importance of XRCC2 in RAD51-related DNA damage repair by Tambini, Cathryn E., Spink, Karen G., Ross, Caroline J., Hill, Mark A., Thacker, John

“…The repair of DNA damage by homologous recombination (HR) is a key pathway for the maintenance of genetic stability in mammalian cells, especially during and…”
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Comparing mutation calls in fixed tumour samples between the affymetrix OncoScan® array and PCR based next-generation sequencing by Wood, Henry M, Foster, Joseph M, Taylor, Morag, Tinkler-Hundal, Emma, Togneri, Fiona S, Wojtowicz, Paula, Oumie, Assa, Spink, Karen G, Brew, Fiona, Quirke, Philip

“…The importance of accurate and affordable mutation calling in fixed pathology samples is becoming increasingly important as we move into the era of…”
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Trion formation in a two-dimensional hole-doped electron gas by Spink, G. G, Ríos, P. López, Drummond, N. D, Needs, R. J

“…Phys. Rev. B 94, 041410(R) (2016) The interaction between a single hole and a two-dimensional, paramagnetic, homogeneous electron gas is studied using…”
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Measuring the action of CPP-siRNA conjugates in the lung by Moschos, Sterghios A, Spink, Karen G, Lindsay, Mark A

“…Two of the most promising and complex areas in biologics development, either as research tools or potential therapeutics, are cell-penetrating peptides (CPPs)…”
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Materials handling systems. A survey of automatic materials distribution systems by Spink, G

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Cranio-cervical junction malformation causing cord compression in infant with achondroplasia: a bigger picture by Caratella, S., Tarazi, M., Tomalieh, F. T., Spink, G., Bukhari, S. U. A., Ahmad, I. H., Hussain, M. M.

“…Achondroplasia is a genetic disorder known for short stature and skeletal abnormalities. We present a case of narrowing of the foramen magnum from a large…”
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Abstract 626: Cross-site reproducibility and orthogonal validation of copy number and somatic mutation calls of OncoScan® FFPE Assay Kit in solid tumors by Foster, Joseph M., Oumie, Assa, Togneri, Fiona S., Taylor, Morag, Alyas, Sofia, Wojtowicz, Paula, Wood, Henry, Tinkler-Hundal, Emma, Southward, Katie, McMullan, Dominic, Quirke, Phil, Keating, Katherine E., Griffiths, Mike, Spink, Karen G., Brew, Fiona, Fung, Eric, Schmidt, Jeanette

“…Objectives Copy number (CN) and somatic mutation (SM) analysis in tumors is rapidly gaining importance in cancer management as a tool for differential…”
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