Search Results - "Spinetti, Gaia"

Impaired Regeneration Contributes to Poor Outcomes in Diabetic Peripheral Artery Disease by Fadini, Gian Paolo, Spinetti, Gaia, Santopaolo, Marianna, Madeddu, Paolo

“…Diabetes mellitus increases the risk and accelerates the course of peripheral artery disease, making patients more susceptible to ischemic events and…”
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A unique plasma microRNA profile defines type 2 diabetes progression by de Candia, Paola, Spinetti, Gaia, Specchia, Claudia, Sangalli, Elena, La Sala, Lucia, Uccellatore, Annachiara, Lupini, Silvia, Genovese, Stefano, Matarese, Giuseppe, Ceriello, Antonio

“…A major unmet medical need to better manage Type 2 Diabetes (T2D) is the accurate disease prediction in subjects who show glucose dysmetabolism, but are not…”
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Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia by Zaccagnini, Germana, Greco, Simona, Longo, Marialucia, Maimone, Biagina, Voellenkle, Christine, Fuschi, Paola, Carrara, Matteo, Creo, Pasquale, Maselli, Davide, Tirone, Mario, Mazzone, Massimiliano, Gaetano, Carlo, Spinetti, Gaia, Martelli, Fabio

“…Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous…”
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Deregulation of microRNA-503 Contributes to Diabetes Mellitus-Induced Impairment of Endothelial Function and Reparative Angiogenesis After Limb Ischemia by CAPORALI, Andrea, MELONI, Marco, AGAMI, Reuven, LE SAGE, Carlos, CONDORELLI, Gianluigi, MADEDDU, Paolo, MARTELLI, Fabio, EMANUELI, Costanza, VÖLLENKLE, Christine, BONCI, Desiree, SALA-NEWBY, Graciela B, ADDIS, Roberta, SPINETTI, Gaia, LOSA, Sergio, MASSON, Rachel, BAKER, Andrew H

“…Diabetes mellitus impairs endothelial cell (EC) function and postischemic reparative neovascularization by molecular mechanisms that are not fully understood…”
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Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus by Faulkner, Ashton, Tamiato, Anita, Cathery, William, Rampin, Andrea, Caravaggi, Carlo Maria, Jover, Eva, Allen, Steve, Mellor, Harry, Hauton, David, Heather, Lisa C., Spinetti, Gaia, Madeddu, Paolo

“…Aims/hypothesis Treatment of vascular complications of diabetes remains inadequate. We reported that muscle pericytes (MPs) from limb muscles of vascular…”
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When a Friend Becomes Your Enemy: Natural Killer Cells in Atherosclerosis and Atherosclerosis-Associated Risk Factors by Palano, Maria Teresa, Cucchiara, Martina, Gallazzi, Matteo, Riccio, Federica, Mortara, Lorenzo, Gensini, Gian Franco, Spinetti, Gaia, Ambrosio, Giuseppe, Bruno, Antonino

“…Atherosclerosis (ATS), the change in structure and function of arteries with associated lesion formation and altered blood flow, is the leading cause of…”
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Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-naïve T2D by La Sala, Lucia, Mrakic-Sposta, Simona, Tagliabue, Elena, Prattichizzo, Francesco, Micheloni, Stefano, Sangalli, Elena, Specchia, Claudia, Uccellatore, Anna Chiara, Lupini, Silvia, Spinetti, Gaia, de Candia, Paola, Ceriello, Antonio

“…Impaired glucose tolerance (IGT) is a risk factor for the development of diabetes and related complications that ensue. Early identification of at-risk…”
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Bone marrow vasculature advanced in vitro models for cancer and cardiovascular research by Campanile, Marzia, Bettinelli, Leonardo, Cerutti, Camilla, Spinetti, Gaia

“…Cardiometabolic diseases and cancer are among the most common diseases worldwide and are a serious concern to the healthcare system. These conditions,…”
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MicroRNA-532-5p Regulates Pericyte Function by Targeting the Transcription Regulator BACH1 and Angiopoietin-1 by Slater, Sadie C., Jover, Eva, Martello, Andrea, Mitić, Tijana, Rodriguez-Arabaolaza, Iker, Vono, Rosa, Alvino, Valeria V., Satchell, Simon C., Spinetti, Gaia, Caporali, Andrea, Madeddu, Paolo

“…MicroRNAs regulate endothelial function and angiogenesis, but their implication in pericyte biology remains undetermined. A PCR array, covering a panel of 379…”
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Diabetes Mellitus Induces Bone Marrow Microangiopathy by Oikawa, Atsuhiko, Siragusa, Mauro, Quaini, Federico, Mangialardi, Giuseppe, Katare, Rajesh G, Caporali, Andrea, van Buul, Jaap D, van Alphen, Floris P.J, Graiani, Gallia, Spinetti, Gaia, Kraenkel, Nicolle, Prezioso, Lucia, Emanueli, Costanza, Madeddu, Paolo

“…OBJECTIVE—The impact of diabetes on the bone marrow (BM) microenvironment was not adequately explored. We investigated whether diabetes induces microvascular…”
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Proinflammatory Profile Within the Grossly Normal Aged Human Aortic Wall by Wang, Mingyi, Zhang, Jing, Jiang, Li-Qun, Spinetti, Gaia, Pintus, Gianfranco, Monticone, Robert, Kolodgie, Frank D, Virmani, Renu, Lakatta, Edward G

“…Studies in animal models demonstrate that angiotensin II and its downstream signaling molecules, that is, matrix metalloproteinases and monocyte…”
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Correction: Hypoxia-induced miR-210 modulates the inflammatory response and fibrosis upon acute ischemia by Zaccagnini, Germana, Greco, Simona, Longo, Marialucia, Maimone, Biagina, Voellenkle, Christine, Fuschi, Paola, Carrara, Matteo, Creo, Pasquale, Maselli, Davide, Tirone, Mario, Mazzone, Massimiliano, Gaetano, Carlo, Spinetti, Gaia, Martelli, Fabio

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Central role of the p53 pathway in the noncoding-RNA response to oxidative stress by Fuschi, Paola, Carrara, Matteo, Voellenkle, Christine, Garcia-Manteiga, Jose Manuel, Righini, Paolo, Maimone, Biagina, Sangalli, Elena, Villa, Francesco, Specchia, Claudia, Picozza, Mario, Nano, Giovanni, Gaetano, Carlo, Spinetti, Gaia, Puca, Annibale A, Magenta, Alessandra, Martelli, Fabio

“…Oxidative stress plays a fundamental role in many conditions. Specifically, redox imbalance inhibits endothelial cell (EC) growth, inducing cell death and…”
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Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems by Spinetti, Gaia, Mutoli, Martina, Greco, Simona, Riccio, Federica, Ben-Aicha, Soumaya, Kenneweg, Franziska, Jusic, Amela, de Gonzalo-Calvo, David, Nossent, Anne Yaël, Novella, Susana, Kararigas, Georgios, Thum, Thomas, Emanueli, Costanza, Devaux, Yvan, Martelli, Fabio

“…Diabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major risk factor…”
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Role for Substance P―Based Nociceptive Signaling in Progenitor Cell Activation and Angiogenesis During Ischemia in Mice and in Human Subjects by AMADESI, Silvia, RENI, Carlotta, ASCIONE, Raimondo, CANGIANO, Elisa, VALGIMIGLI, Marco, HUNT, Stephen P, EMANUELI, Costanza, MADEDDU, Paolo, KATARE, Rajesh, MELONI, Marco, OIKAWA, Atsuhiko, BELTRAMI, Antonio P, AVOLIO, Elisa, CESSELLI, Daniela, FORTUNATO, Orazio, SPINETTI, Gaia

“…Pain triggers a homeostatic alarm reaction to injury. It remains unknown, however, whether nociceptive signaling activated by ischemia is relevant for…”
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HCG18, LEF1AS1 and lncCEACAM21 as biomarkers of disease severity in the peripheral blood mononuclear cells of COVID-19 patients by Greco, Simona, Made', Alisia, Mutoli, Martina, Zhang, Lu, Piella, Santiago Nicolas, Vausort, Mélanie, Lumley, Andrew I, Beltrami, Antonio Paolo, Srivastava, Prashant Kumar, Milani, Valentina, Boveri, Sara, Ranucci, Marco, Renna, Laura Valentina, Firat, Hüseyin, Bruno, Antonino, Spinetti, Gaia, Emanueli, Costanza, Devaux, Yvan, Martelli, Fabio

“…Even after 3 years from SARS-CoV-2 identification, COVID-19 is still a persistent and dangerous global infectious disease. Significant improvements in our…”
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Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall by Wang, Mingyi, Zhao, Di, Spinetti, Gaia, Zhang, Jing, Jiang, Li-Qun, Pintus, Gianfranco, Monticone, Robert, Lakatta, Edward G

“…OBJECTIVE—To study matrix metalloproteinase 2 (MMP-2) effects on transforming growth factor-β1 (TGF-β1) activation status and downstream signaling during…”
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Results of a prospective observational study of autologous peripheral blood mononuclear cell therapy for no-option critical limb-threatening ischemia and severe diabetic foot ulcers by Panunzi, Andrea, Madotto, Fabiana, Sangalli, Elena, Riccio, Federica, Sganzaroli, Adriana Barbara, Galenda, Paolo, Bertulessi, Amelia, Barmina, Maria Francesca, Ludovico, Ornella, Fortunato, Orazio, Setacci, Francesco, Airoldi, Flavio, Tavano, Davide, Giurato, Laura, Meloni, Marco, Uccioli, Luigi, Bruno, Antonino, Spinetti, Gaia, Caravaggi, Carlo Maria Ferdinando

“…Abstract Background Cell therapy with autologous peripheral blood mononuclear cells (PB-MNCs) may help restore limb perfusion in patients with diabetes…”
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MicroRNAs orchestrating senescence of endothelial and vascular smooth muscle cells by Colpani, Ornella, Spinetti, Gaia

“…During organism aging, the process of cellular senescence is triggered by critical stressors such as DNA damage, oncogenes, oxidative stress, and telomere…”
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Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor–Dependent Pathways by Krug, Alexander W, Allenhöfer, Lena, Monticone, Robert, Spinetti, Gaia, Gekle, Michael, Wang, Mingyi, Lakatta, Edward G

“…Arterial aging is a predominant risk factor for the onset of cardiovascular diseases, such as hypertension, myocardial infarction, or stroke. Aging is…”
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