Search Results - "Spindler, Felix"

From a Chiral Switch to a Ligand Portfolio for Asymmetric Catalysis by Blaser, Hans-Ulrich, Pugin, Benoît, Spindler, Felix, Thommen, Marc

“…This Account is divided into two sections. In the first section, the development of an enantioselective manufacturing process for (S)-metolachlor, the active…”
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Highly Efficient Asymmetric Synthesis of Sitagliptin by Hansen, Karl B, Hsiao, Yi, Xu, Feng, Rivera, Nelo, Clausen, Andrew, Kubryk, Michele, Krska, Shane, Rosner, Thorsten, Simmons, Bryon, Balsells, Jaume, Ikemoto, Nori, Sun, Yongkui, Spindler, Felix, Malan, Christophe, Grabowski, Edward J. J, Armstrong, Joseph D

“…A highly efficient synthesis of sitagliptin, a potent and selective DPP-4 inhibitor for the treatment of type 2 diabetes mellitus (T2DM), has been developed…”
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Selective Hydrogenation for Fine Chemicals: Recent Trends and New Developments by Blaser, Hans-Ulrich, Malan, Christophe, Pugin, Benoît, Spindler, Felix, Steiner, Heinz, Studer, Martin

“…In this overview, recent trends and developments for the selective hydrogenation of multifunctional molecules are discussed and assessed from the point of view…”
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Chiral Mixed Secondary Phosphine-Oxide-Phosphines: High-Performing and Easily Accessible Ligands for Asymmetric Hydrogenation by Landert, Heidi, Spindler, Felix, Wyss, Adrian, Blaser, Hans-Ulrich, Pugin, Benoît, Ribourduoille, Yann, Gschwend, Björn, Ramalingam, Balamurugan, Pfaltz, Andreas

“…P&O: Combining secondary phosphine oxides (SPOs) with phosphines leads to highly effective chiral bidentate ligands for transition‐metal‐based catalysts…”
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Progress in enantioselective catalysis assessed from an industrial point of view by Blaser, Hans-Ulrich, Pugin, Benoît, Spindler, Felix

“…In this overview, the opportunities and problems associated with the industrial application of chiral catalysts (restricted to homogeneous metal complexes and…”
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Chiral Xyliphos Complexes for the Catalytic Imine Hydrogenation Leading to the Metolachlor Herbicide: Isolation of Catalyst-Substrate Adducts by Dorta, Romano, Broggini, Diego, Stoop, Robert, Rüegger, Heinz, Spindler, Felix, Togni, Antonio

“…Iridium complexes relevant to the catalytic enantioselective hydrogenation of 2‐methyl‐6‐ethylphenyl‐1′‐methyl‐2′‐methoxyethylimine (MEA‐imine, 1) in the…”
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Synthesis, Coordination Behavior, and Use in Asymmetric Hydrogenations of Walphos-Type Ligands by Wang, Yaping, Sturm, Thomas, Steurer, Marianne, Arion, Vladimir B, Mereiter, Kurt, Spindler, Felix, Weissensteiner, Walter

“…A total of nine Walphos-type diphosphine ligands, all of which have a ferrocenyl-aryl backbone, have been synthesized, characterized, and tested in asymmetric…”
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A Novel Easily Accessible Chiral Ferrocenyldiphosphine for Highly Enantioselective Hydrogenation, Allylic Alkylation, and Hydroboration Reactions by Togni, Antonio, Breutel, Claude, Schnyder, Anita, Spindler, Felix, Landert, Heidi, Tijani, Amina

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Biotin – The Chiral Challenge by Werner Bonrath, Reinhard Karge, Thomas Netscher, Felix Roessler, Felix Spindler

“…In this contribution, the first examples of the catalytic highly enantioselective reduction of cyclic meso-anhydrides to lactones and of thioanhydrides to…”
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Synthesis of Substituted Mandelic Acid Derivatives via Enantioselective Hydrogenation: Homogeneous versus Heterogeneous Catalysis by Cederbaum, Fredrik, Lamberth, Clemens, Malan, Christophe, Naud, Fred, Spindler, Felix, Studer, Martin, Blaser, Hans-Ulrich

“…An extensive screening of both homogeneous and heterogeneous catalysts was carried out for the enantioselective hydrogenation of p‐chlorophenylglyoxylic acid…”
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Exploring Stereogenic Phosphorus:  Synthetic Strategies for Diphosphines Containing Bulky, Highly Symmetric Substituents by Maienza, Francesca, Spindler, Felix, Thommen, Marc, Pugin, Benoît, Malan, Christophe, Mezzetti, Antonio

“…Diphosphine ligands bearing highly symmetric, bulky substituents at a stereogenic P atom were prepared, exploiting established protocols, which include the use…”
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Homo- and Heteroannularly Bridged Ferrocenyl Diphosphines in Asymmetric Hydrogenations by Sturm, Thomas, Weissensteiner, Walter, Spindler, Felix, Mereiter, Kurt, López-Agenjo, Ana M, Manzano, Blanca R, Jalón, Félix A

“…Four new enantiopure homo- and heteroannularly bridged ferrocenyl diphosphine ligands have been synthesized, characterized, and tested in enantioselective…”
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Modular chiral ligands: the profiling of the Mandyphos and Taniaphos ligand families by Spindler, Felix, Malan, Christophe, Lotz, Matthias, Kesselgruber, Martin, Pittelkow, Ulrich, Rivas-Nass, Andreas, Briel, Oliver, Blaser, Hans-Ulrich

“…■■■ A set of 11 ferrocenyl based diphosphine ligands (eight Mandyphos and three Taniaphos) was tested in more than 150 experiments using 20 test reactions. For…”
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Strategies for Accelerating the Development of Catalytic Enantioselective Reactions by Hans-Ulrich Blaser, Garrett Hoge, Matthias Lotz, Ulrike Nettekoven, Anita Schnyder, Felix Spindler

“…The development of enantioselective catalytic processes for the manufacture of chiral intermediates is a very complex endeavor and can be very time consuming…”
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ChenPhos: Highly Modular P-Stereogenic C1-Symmetric Diphosphine Ligands for the Efficient Asymmetric Hydrogenation of α-Substituted Cinnamic Acids by Chen, Weiping, Spindler, Felix, Pugin, Benoit, Nettekoven, Ulrike

“…These cats are purrfectionists: The ChenPhos ligands (see structure) showed dramatically higher catalytic activity in the title reaction than their…”
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ChenPhos: Highly Modular P‐Stereogenic C 1 ‐Symmetric Diphosphine Ligands for the Efficient Asymmetric Hydrogenation of α‐Substituted Cinnamic Acids by Chen, Weiping, Spindler, Felix, Pugin, Benoit, Nettekoven, Ulrike

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The development of a practical synthesis of the potent and selective somatostatin sst3 receptor antagonist [4-(3,4-difluoro-phenyl)-piperazine-1-yl]-{(4S,4aS,8aR)-2[(S)-3-(6-methoxy-pyridin-3-yl)-2-methyl-propyl]-decahydroisoquinoline-4-yl}-methanone (NVP-ACQ090) by Bänziger, Markus, Cercus, Jacques, Hirt, Hans, Laumen, Kurt, Malan, Christophe, Spindler, Felix, Struber, Fritz, Troxler, Thomas

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A convergent synthesis approach towards CGP60536B, a non-peptide orally potent renin inhibitor, via an enantiomerically pure ketolactone intermediate by Rüeger, Heinrich, Stutz, Stefan, Göschke, Richard, Spindler, Felix, Maibaum, Jürgen

“…We report a convergent synthesis of the potent orally active non-peptide renin inhibitor CGP60536B. The key reaction employs the coupling of the enantiopure…”
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The Chiral Switch of Metolachlor: The Development of a Large-Scale Enantioselective Catalytic Process by Hans-Ulrich Blaser, Felix Spindler, Hans-Dieter Schneider, Benoît Pugin, Eric Jelsch, Hans-Peter Jalett, Reinhard Hanreich, Klaus Coers, Hans-Peter Buser, Arthur Wegmann

“…The development of an enantioselective catalytic process for the technical preparation of chiral agrochemicals is illustrated by the case history of the…”
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Having Fun (and Commercial Success) with Josiphos and Related Chiral Ferrocene Based Ligands by Blaser, Hans Ulrich, Pugin, Benoît, Spindler, Felix

“…The Josiphos ligand family is arguably one of the most versatile classes of chiral ligands with a wide range of applications, including one of the two largest…”
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