Search Results - "Spinaci, Andrea"

Combined Therapy of A1AR Agonists and A2AAR Antagonists in Neuroinflammation by Marucci, Gabriella, Ben, Diego Dal, Lambertucci, Catia, Navia, Aleix Martí, Spinaci, Andrea, Volpini, Rosaria, Buccioni, Michela

“…Alzheimer’s, Parkinson’s, and multiple sclerosis are neurodegenerative diseases related by neuronal degeneration and death in specific areas of the central…”
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P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications by Spinaci, Andrea, Buccioni, Michela, Dal Ben, Diego, Marucci, Gabriella, Volpini, Rosaria, Lambertucci, Catia

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Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A2A Adenosine Receptor Useful in Neurodegenerative Disorders by Francucci, Beatrice, Angeloni, Simone, Dal Ben, Diego, Lambertucci, Catia, Ricciutelli, Massimo, Spinaci, Andrea, Smirnov, Aleksei, Volpini, Rosaria, Buccioni, Michela, Marucci, Gabriella

“…Currently, the number of patients with neurodegenerative pathologies is estimated at over one million, with consequences also on the economic level. Several…”
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A2A Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable? by Spinaci, Andrea, Lambertucci, Catia, Buccioni, Michela, Dal Ben, Diego, Graiff, Claudia, Barbalace, Maria Cristina, Hrelia, Silvana, Angeloni, Cristina, Tayebati, Seyed Khosrow, Ubaldi, Massimo, Masi, Alessio, Klotz, Karl-Norbert, Volpini, Rosaria, Marucci, Gabriella

“…The A2A adenosine receptor (A2AAR) is one of the four subtypes activated by nucleoside adenosine, and the molecules able to selectively counteract its action…”
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The G Protein-Coupled Receptor GPR17: Overview and Update by Marucci, Gabriella, Dal Ben, Diego, Lambertucci, Catia, Santinelli, Claudia, Spinaci, Andrea, Thomas, Ajiroghene, Volpini, Rosaria, Buccioni, Michela

“…The GPR17 receptor is a G protein‐coupled receptor (GPCR) that seems to respond to two unrelated families of endogenous ligands: nucleotide sugars (UDP,…”
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Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta by Calenda, Sara, Catarzi, Daniela, Varano, Flavia, Vigiani, Erica, Volpini, Rosaria, Lambertucci, Catia, Spinaci, Andrea, Trevisan, Letizia, Grieco, Ilenia, Federico, Stephanie, Spalluto, Giampiero, Novello, Gianluca, Salmaso, Veronica, Moro, Stefano, Colotta, Vittoria

“…Protein kinase CK1δ (CK1δ) is a serine-threonine/kinase that modulates different physiological processes, including the cell cycle, DNA repair, and apoptosis…”
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A3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity by Spinaci, Andrea, Buccioni, Michela, Dal Ben, Diego, Maggi, Federica, Marucci, Gabriella, Francucci, Beatrice, Santoni, Giorgio, Lambertucci, Catia, Volpini, Rosaria

“…The overexpression of the A3 adenosine receptor (AR) in a number of cancer cell types makes it an attractive target for tumor diagnosis and therapy. Hence, in…”
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Adenosine receptors as neuroinflammation modulators: role of A1 agonists and A2A antagonists by Martí Navia, Aleix, Dal Ben, Diego, Lambertucci, Catia, Spinaci, Andrea, Volpini, Rosaria, Marques-Morgado, Inês, Coelho, Joana, Lopes, Luisa, Marucci, Gabriella, Buccioni, Michela

“…© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative…”
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“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies by Spinaci, Andrea, Buccioni, Michela, Catarzi, Daniela, Cui, Chang, Colotta, Vittoria, Dal Ben, Diego, Cescon, Eleonora, Francucci, Beatrice, Grieco, Ilenia, Lambertucci, Catia, Marucci, Gabriella, Bassani, Davide, Pavan, Matteo, Varano, Flavia, Federico, Stephanie, Spalluto, Giampiero, Moro, Stefano, Volpini, Rosaria

“…Based on a screening of a chemical library of A2A adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were synthesized…”
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Non-Nucleoside Agonists of the Adenosine Receptors: An Overview by Dal Ben, Diego, Lambertucci, Catia, Buccioni, Michela, Martí Navia, Aleix, Marucci, Gabriella, Spinaci, Andrea, Volpini, Rosaria

“…Potent and selective adenosine receptor (AR) agonists are of pharmacological interest for the treatment of a wide range of diseases and conditions. Among these…”
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The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis by Antonioli, Luca, Lucarini, Elena, Lambertucci, Catia, Fornai, Matteo, Pellegrini, Carolina, Benvenuti, Laura, Di Cesare Mannelli, Lorenzo, Spinaci, Andrea, Marucci, Gabriella, Blandizzi, Corrado, Ghelardini, Carla, Volpini, Rosaria, Dal Ben, Diego

“…The pharmacological activation of A3 receptors has shown potential usefulness in the management of bowel inflammation. However, the role of these receptors in…”
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Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands by Zuccarini, Mariachiara, Lambertucci, Catia, Carluccio, Marzia, Giuliani, Patricia, Ronci, Maurizio, Spinaci, Andrea, Volpini, Rosaria, Ciccarelli, Renata, Di Iorio, Patrizia

“…Adenosine A1 receptor (A1R) activation, stimulating lipogenesis and decreasing insulin resistance, could be useful for metabolic syndrome management in obese…”
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Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications by Marucci, Gabriella, Dal Ben, Diego, Buccioni, Michela, Martí Navia, Aleix, Spinaci, Andrea, Volpini, Rosaria, Lambertucci, Catia

“…: Purinergic P2X3-P2X2/3 receptors are placed in nociceptive neurons' strategic location and show unique desensitization properties; hence, they represent an…”
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A patent review of adenosine A 2B receptor antagonists (2016-present) by Francucci, Beatrice, Dal Ben, Diego, Lambertucci, Catia, Spinaci, Andrea, Volpini, Rosaria, Marucci, Gabriella, Buccioni, Michela

“…A adenosine receptor (A AR) plays a crucial role in pathophysiologic conditions associated with high adenosine release, typical of airway inflammatory…”
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Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A[sub.2A] Adenosine Receptor Useful in Neurodegenerative Disorders by Francucci, Beatrice, Angeloni, Simone, Dal Ben, Diego, Lambertucci, Catia, Ricciutelli, Massimo, Spinaci, Andrea, Smirnov, Aleksei, Volpini, Rosaria, Buccioni, Michela, Marucci, Gabriella

“…Currently, the number of patients with neurodegenerative pathologies is estimated at over one million, with consequences also on the economic level. Several…”
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Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity by Betti, Marco, Catarzi, Daniela, Varano, Flavia, Falsini, Matteo, Varani, Katia, Vincenzi, Fabrizio, Pasquini, Silvia, di Cesare Mannelli, Lorenzo, Ghelardini, Carla, Lucarini, Elena, Dal Ben, Diego, Spinaci, Andrea, Bartolucci, Gianluca, Menicatti, Marta, Colotta, Vittoria

“…A new series of amino-3,5-dicyanopyridines (1–31) was synthesized and biologically evaluated in order to further investigate the potential of this scaffold to…”
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A 3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity by Spinaci, Andrea, Buccioni, Michela, Dal Ben, Diego, Maggi, Federica, Marucci, Gabriella, Francucci, Beatrice, Santoni, Giorgio, Lambertucci, Catia, Volpini, Rosaria

“…The overexpression of the A adenosine receptor (AR) in a number of cancer cell types makes it an attractive target for tumor diagnosis and therapy. Hence, in…”
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New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases by Lambertucci, Catia, Marucci, Gabriella, Dal Ben, Diego, Buccioni, Michela, Spinaci, Andrea, Kachler, Sonja, Klotz, Karl-Norbert, Volpini, Rosaria

“…The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl rings in 8- and N6-position, respectively, is reported. The…”
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Adenine derivatives as inhibitors of the casein kinase CK1delta enzyme by Spinaci, Andrea, Lambertucci, Catia, Chang, Cui, Buccioni, Michela, Marucci, Gabriella, Cescon, Eleonora, Federico, Stephanie, Spalluto, Giampiero, Dal Ben, Diego, Volpini, Rosaria

“…Overexpression of CK1δ has been associated to the development of cancer and neurodegenerative disorders, making ligands of this protein very promising drug…”
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“Dual Anta-Inhibitors” of the A[sub.2A] Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies by Spinaci, Andrea, Buccioni, Michela, Catarzi, Daniela, Cui, Chang, Colotta, Vittoria, Dal Ben, Diego, Cescon, Eleonora, Francucci, Beatrice, Grieco, Ilenia, Lambertucci, Catia, Marucci, Gabriella, Bassani, Davide, Pavan, Matteo, Varano, Flavia, Federico, Stephanie, Spalluto, Giampiero, Moro, Stefano, Volpini, Rosaria

“…Based on a screening of a chemical library of A[sub.2A] adenosine receptor (AR) antagonists, a series of di- and tri-substituted adenine derivatives were…”
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