Search Results - "Spina, E."

Efficacy of Antidepressants: Issues Related to Bias in Clinical Trials by Spina, E

“…[...]concerns over potential adverse effects of antidepressants, including an increased risk of "suicidality" in younger populations, have continued to darken…”
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The economic burden of preventable adverse drug reactions: a systematic review of observational studies by Formica, D, Sultana, J, Cutroneo, P M, Lucchesi, S, Angelica, R, Crisafulli, S, Ingrasciotta, Y, Salvo, F, Spina, E, Trifirò, G

“…Adverse drug reactions (ADRs) are an important cause of morbidity and mortality worldwide. They are associated with healthcare costs due to hospital admissions…”
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Mutations in the estrogen receptor alpha hormone binding domain promote stem cell phenotype through notch activation in breast cancer cell lines by Gelsomino, L., Panza, S., Giordano, C., Barone, I., Gu, G., Spina, E., Catalano, S., Fuqua, S., Andò, S.

“…The detection of recurrent mutations affecting the hormone binding domain (HBD) of estrogen receptor alpha (ERα/ESR1) in endocrine therapy-resistant and…”
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High-density neutrophils in MGUS and multiple myeloma are dysfunctional and immune-suppressive due to increased STAT3 downstream signaling by Romano, A., Parrinello, N. L., Simeon, V., Puglisi, F., La Cava, P., Bellofiore, C., Giallongo, C., Camiolo, G., D’Auria, F., Grieco, V., Larocca, F., Barbato, A., Cambria, D., La Spina, E., Tibullo, D., Palumbo, G. A., Conticello, C., Musto, P., Di Raimondo, F.

“…To understand neutrophil impairment in the progression from MGUS through active MM, we investigated the function of mature, high-density neutrophils (HDNs),…”
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Early atypical injection‐site reactions to COVID‐19 vaccine: a case series by Vaccaro, M., Bertino, L., Squeri, R., Genovese, C., Isola, S., Spatari, G., Spina, E., Cutroneo, P.

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First-admissions in Psychiatry: a cluster analysis of a sample of inpatients from 2019 to 2021 by La Spina, E., Mastrangelo, M., Montalbani, B., Mancinelli, I., Del Casale, A., Comparelli, A., Pompili, M.

“…Introduction Only a few studies analyse the clinical and psychopathological characteristics of first-admitted inpatients regardless of diagnosis. Objectives…”
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Progressive thrombosis of cervical and intracranial arteries related to Ponatinib treatment for Chronic Myeloid Leukemia by Spina, E, Renna, R, Lanterna, LA, Colleoni, ML, Andreone, V

“…Ponatinib is a third-generation Tyrosine Kinase Inhibitor (TKI), approved as first-line treatment for Chronic Myeloid Leukaemia (CML) chronic phase. Here we…”
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Antiepileptic drugs: indications other than epilepsy by Spina, Edoardo, Perugi, Giulio

“…Antiepileptic drugs (AEDs) are increasingly used for the treatment of several non-epileptic neurological conditions and psychiatric disorders. Most of the…”
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Tools for optimising pharmacotherapy in psychiatry (therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests): focus on antidepressants by Eap, C. B., Gründer, G., Baumann, P., Ansermot, N., Conca, A., Corruble, E., Crettol, S., Dahl, M. L., de Leon, J., Greiner, C., Howes, O., Kim, E., Lanzenberger, R., Meyer, J. H., Moessner, R., Mulder, H., Müller, D. J., Reis, M., Riederer, P., Ruhe, H. G., Spigset, O., Spina, E., Stegman, B., Steimer, W., Stingl, J., Suzen, S., Uchida, H., Unterecker, S., Vandenberghe, F., Hiemke, C.

“…Objectives: More than 40 drugs are available to treat affective disorders. Individual selection of the optimal drug and dose is required to attain the highest…”
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CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants:a first step towards subpopulation-specific dosages by Kirchheiner, J., Brøsen, K., Dahl, M. L., Gram, L. F., Kasper, S., Roots, I., Sjöqvist, F., Spina, E., Brockmöller, J.

“…Objective: This review aimed to provide distinct dose recommendations for antidepressants based on the genotypes of cytochrome P450 enzymes CYP2D6 and CYP2C19…”
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The effect of lamotrigine augmentation of clozapine in a sample of treatment-resistant schizophrenic patients: A double-blind, placebo-controlled study by Zoccali, R, Muscatello, M.R, Bruno, A, Cambria, R, Micò, U, Spina, E, Meduri, M

“…Abstract Based on the evidence that lamotrigine added to clozapine in refractory schizophrenic patients has reported promising results, the present 24-week…”
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High-resolution profiling of linear B-cell epitopes from mucin-associated surface proteins (MASPs) of Trypanosoma cruzi during human infections by Durante, Ignacio M, La Spina, Pablo E, Carmona, Santiago J, Agüero, Fernán, Buscaglia, Carlos A

“…The Trypanosoma cruzi genome bears a huge family of genes and pseudogenes coding for Mucin-Associated Surface Proteins (MASPs). MASP molecules display a…”
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Salivary Gland Ultrasound in Primary Sjögren’s Syndrome: Current and Future Perspectives by Lorenzon, Michele, Spina, Erica, Franco, Francesco Tulipano Di, Giovannini, Ivan, De Vita, Salvatore, Zabotti, Alen

“…Salivary gland ultrasound (SGUS) is the imaging modality of choice for the assessment of parotid and submandibular gland parenchyma. Being highly effective,…”
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Motor performance deterioration accelerates after 50 years of age in Charcot‐Marie‐Tooth type 1A patients by Tozza, S., Bruzzese, D., Pisciotta, C., Iodice, R., Esposito, M., Dubbioso, R., Ruggiero, L., Topa, A., Spina, E., Santoro, L., Manganelli, F.

“…Background and purpose The aim of our study was to describe, by a case‐control and cross‐sectional design, the correlation between clinical impairment and age…”
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Can valproic acid be an inducer of clozapine metabolism? by Diaz, F J, Eap, C B, Ansermot, N, Crettol, S, Spina, E, de Leon, J

“…Prior clozapine studies indicated no effects, mild inhibition or induction of valproic acid (VPA) on clozapine metabolism. The hypotheses that (i) VPA is a net…”
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Pharmacokinetics of Paliperidone Palmitate in Schizophrenic Patients: Data from a Routine Therapeutic Drug Monitoring Service by Santoro, V, Bruno, A, Muscatello, M.R, D’Amico, G, Nucifora, D, Zoccali, R, Spina, E

“…Methods Samples sent to the Clinical Pharmacology Unit, Messina University Hospital, for routine TDM from schizophrenic patients receiving depot injections of…”
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Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005 by Savica, R., Beghi, E., Mazzaglia, G., Innocenti, F., Brignoli, O., Cricelli, C., Caputi, A. P., Musolino, R., Spina, E., Trifirò, G.

“…To evaluate prevalence of use and prescribing patterns of antiepileptic drugs (AEDs) in Italian general practice. Primary care data were obtained from the…”
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EKG Parameters in Children and Adolescents Treated with Second-Generation Antipsychotics: A 24-Months Prospective Follow-Up Study by Lamberti, M, Gagliano, A, Italiano, D, Morello, A, Guerriero, L, D’Amico, G, Germanò, E, Calabrò, M, Persico, A, Spina, E

“…Background Second-generation antipsychotics (APs) are increasingly prescribed in pediatric patients for the treatment of a number of psychiatric disorders…”
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EKG parameters in children and adolescents treated with second-generation antipsychotics: a 1-year prospective follow-up study by Lamberti, M, Gagliano, A, Italiano, D, Morello, A, Guerriero, L, D’Amico, G, Germanò, E, Calabrò, M, Spina, E, Persico, A

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Estimating the size of the effects of co-medications on plasma clozapine concentrations using a model that controls for clozapine doses and confounding variables by Diaz, F J, Santoro, V, Spina, E, Cogollo, M, Rivera, T E, Botts, S, de Leon, J

“…The purpose of this study was to estimate the effect sizes of drug interactions on plasma clozapine concentrations, adjusting for potentially confounding…”
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