Search Results - "Spina, Catherine S."

Antibiotic treatment expands the resistance reservoir and ecological network of the phage metagenome by Modi, Sheetal R., Lee, Henry H., Spina, Catherine S., Collins, James J.

“…By exploring the phageome in mice, antibiotic treatment is shown to lead to enrichment of phage-encoded genes that are related to antibiotic resistance. Gut…”
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Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro by Torisawa, Yu-suke, Spina, Catherine S, Mammoto, Tadanori, Mammoto, Akiko, Weaver, James C, Tat, Tracy, Collins, James J, Ingber, Donald E

“…Bone marrow formed in a cylindrical PDMS device implanted in a mouse can be surgically removed and cultured for a week in vitro without losing any of the…”
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Silver enhances antibiotic activity against gram-negative bacteria by Morones-Ramirez, J Ruben, Winkler, Jonathan A, Spina, Catherine S, Collins, James J

“…A declining pipeline of clinically useful antibiotics has made it imperative to develop more effective antimicrobial therapies, particularly against…”
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Bactericidal antibiotics induce mitochondrial dysfunction and oxidative damage in Mammalian cells by Kalghatgi, Sameer, Spina, Catherine S, Costello, James C, Liesa, Marc, Morones-Ramirez, J Ruben, Slomovic, Shimyn, Molina, Anthony, Shirihai, Orian S, Collins, James J

“…Prolonged antibiotic treatment can lead to detrimental side effects in patients, including ototoxicity, nephrotoxicity, and tendinopathy, yet the mechanisms…”
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Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma by Powers, John T., Tsanov, Kaloyan M., Pearson, Daniel S., Roels, Frederik, Spina, Catherine S., Ebright, Richard, Seligson, Marc, de Soysa, Yvanka, Cahan, Patrick, Theißen, Jessica, Tu, Ho-Chou, Han, Areum, Kurek, Kyle C., LaPier, Grace S., Osborne, Jihan K., Ross, Samantha J., Cesana, Marcella, Collins, James J., Berthold, Frank, Daley, George Q.

“…Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN . MYCN is itself a target of let-7 , a tumour suppressor family of microRNAs…”
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Lin28 sustains early renal progenitors and induces Wilms tumor by Urbach, Achia, Yermalovich, Alena, Zhang, Jin, Spina, Catherine S, Zhu, Hao, Perez-Atayde, Antonio R, Shukrun, Rachel, Charlton, Jocelyn, Sebire, Neil, Mifsud, William, Dekel, Benjamin, Pritchard-Jones, Kathy, Daley, George Q

“…Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that…”
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SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production by Chen, Liyun, Shi, Victoria, Wang, Songyan, Sun, Lulu, Freeman, Rebecca, Yang, Jasmine, Inkman, Matthew J, Ghosh, Subhajit, Ruiz, Fiona, Jayachandran, Kay, Huang, Yi, Luo, Jingqin, Zhang, Jin, Cosper, Pippa, Luke, Clifford J, Spina, Catherine S, Grigsby, Perry W, Schwarz, Julie K, Markovina, Stephanie

“…Patients with cancer who have high serum levels of squamous cell carcinoma antigen 1 (SCCA1, now referred to as SERPINB3) commonly experience treatment…”
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Stereotactic body radiotherapy with periprostatic hydrogel spacer for localized prostate cancer: toxicity profile and early oncologic outcomes by Hwang, Mark E, Mayeda, Mark, Liz, Maria, Goode-Marshall, Brenda, Gonzalez, Lissette, Elliston, Carl D, Spina, Catherine S, Padilla, Oscar A, Wenske, Sven, Deutsch, Israel

“…Multiple phase I-II clinical trials have reported on the efficacy and safety of prostate stereotactic body radiotherapy (SBRT) for the treatment of prostate…”
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Enhancing Safety in AI-Driven Cone Beam CT-based Online Adaptive Radiation Therapy: Development and Implementation of an Interdisciplinary Workflow by Wang, Yi-Fang, Price, Michael J., Elliston, Carl D., Munbodh, Reshma, Spina, Catherine S., Horowitz, David P., Kachnic, Lisa A.

“…The emerging online adaptive radiation therapy (OART) treatment strategy based on cone beam computed tomography allows for real-time replanning according to a…”
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Potentiating antibacterial activity by predictably enhancing endogenous microbial ROS production by Brynildsen, Mark P, Winkler, Jonathan A, Spina, Catherine S, MacDonald, I Cody, Collins, James J

“…The first global metabolic models that incorporate reactive oxygen species in E. coli reveal targets for potentiating the action of antibacterials. The…”
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Blocking IL1 Beta Promotes Tumor Regression and Remodeling of the Myeloid Compartment in a Renal Cell Carcinoma Model: Multidimensional Analyses by Aggen, David H, Ager, Casey R, Obradovic, Aleksandar Z, Chowdhury, Nivedita, Ghasemzadeh, Ali, Mao, Wendy, Chaimowitz, Matthew G, Lopez-Bujanda, Zoila A, Spina, Catherine S, Hawley, Jessica E, Dallos, Matthew C, Zhang, Cheng, Wang, Vinson, Li, Hu, Guo, Xinzheng V, Drake, Charles G

“…Intratumoral immunosuppression mediated by myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) represents a potential mechanism of…”
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Mechanisms of Immune Modulation by Radiation by Spina, Catherine S., Drake, Charles G.

“…Radiation is a known immune modulator that drives both local and systemic immunologic effects. There is increasing interest and investigation into harnessing…”
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Dosimetric feasibility of neurovascular bundle-sparing stereotactic body radiotherapy with periprostatic hydrogel spacer for localized prostate cancer to preserve erectile function by Hwang, Mark E, Mayeda, Mark, Shaish, Hiram, Elliston, Carl D, Spina, Catherine S, Wenske, Sven, Deutsch, Israel

“…We aim to test the hypothesis that neurovascular bundle (NVB) displacement by rectal hydrogel spacer combined with NVB delineation as an organ at risk (OAR) is…”
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The Significance of a Pathologic Complete Response in Patients With Soft Tissue Sarcoma by Spina, Catherine S, DeLaney, Thomas F

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Preliminary efficacy of [90Y]DOTA-biotin-avidin radiotherapy against non-muscle invasive bladder cancer by Alì, Alessandra, Leibowitz, Dev, Bhatt, Nikunj, Doubrovin, Mikhail, Spina, Catherine S., Bates-Pappas, Gleneara E., Taub, Robert N., McKiernan, James M., Mintz, Akiva, Molotkov, Andrei

“…   Purpose Bladder cancer represents 3% of all new cancer diagnoses per year. We propose intravesical radionuclide therapy using the β-emitter 90 Y linked to…”
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Differential Immune Modulation With Carbon-Ion Versus Photon Therapy by Spina, Catherine S., Tsuruoka, Chizuru, Mao, Wendy, Sunaoshi, M. Masaaki, Chaimowitz, Matthew, Shang, Yi, Welch, David, Wang, Yi-Fang, Venturini, Nicholas, Kakinuma, Shizuko, Drake, Charles G.

“…Radiation therapy (RT) modulates the immune characteristics of the tumor microenvironment (TME). It is not known whether these effects are dependent on the…”
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Velocity-based Adaptive Registration and Fusion for Fractionated Stereotactic Radiosurgery Using the Small Animal Radiation Research Platform by Black, Paul J., Smith, Deborah R., Chaudhary, Kunal, Xanthopoulos, Eric P., Chin, Christine, Spina, Catherine S., Hwang, Mark E., Mayeda, Mark, Wang, Yi-Fang, Connolly, Eileen P., Wang, Tony J.C., Wuu, Cheng-Shie, Hei, Tom K., Cheng, Simon K., Wu, Cheng-Chia

“…To implement Velocity-based image fusion and adaptive deformable registration to enable treatment planning for preclinical murine models of fractionated…”
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Combined local and systemic attacks by Spina, Catherine S., Drake, Charles G.

“…Intratumoral injection of a hydrogel impregnated with radioisotope-labelled catalase and an immunostimulant, along with systemic immune checkpoint blockade,…”
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Temporalis muscle width as a measure of sarcopenia correlates with overall survival in patients with newly diagnosed glioblastoma by Hsieh, Kristin, Hwang, Mark E., Estevez-Inoa, Gabrielle, Save, Akshay V., Saraf, Anurag, Spina, Catherine S., Cheng, Simon K., Wang, Tony J. C., Wu, Cheng-Chia

“…Objective Sarcopenia has been shown to correlate with poor oncologic outcomes, but the optimal method to evaluate sarcopenia and its use as a prognostic tool…”
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Combined administration of testosterone plus an ornithine decarboxylase inhibitor as a selective prostate‐sparing anabolic therapy by Jasuja, Ravi, Costello, James C., Singh, Rajan, Gupta, Vandana, Spina, Catherine S., Toraldo, Gianluca, Jang, Hyeran, Li, Hu, Serra, Carlo, Guo, Wen, Chauhan, Pratibha, Narula, Navjot S., Guarneri, Tyler, Ergun, Ayla, Travison, Thomas G., Collins, James J., Bhasin, Shalender

“…Summary Because of its anabolic effects on muscle, testosterone is being explored as a function‐promoting anabolic therapy for functional limitations…”
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