Search Results - "Spina, C A"

Heterogeneous Clearance Rates of Long-Lived Lymphocytes Infected with HIV: Intrinsic Stability Predicts Lifelong Persistence by Strain, M. C., Günthard, H. F., Havlir, D. V., Ignacio, C. C., Smith, D. M., Leigh-Brown, A. J., Macaranas, T. R., Lam, R. Y., Daly, O. A., Fischer, M., Opravil, M., Levine, H., Bacheler, L., Spina, C. A., Richman, D. D., Wong, J. K.

“…Viral replication and latently infected cellular reservoirs persist in HIV-infected patients achieving undetectable plasma virus levels with potent…”
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Recovery of Replication-Competent HIV Despite Prolonged Suppression of Plasma Viremia by Wong, Joseph K., Hezareh, Marjan, Gunthard, Huldrych F., Havlir, Diane V., Ignacio, Caroline C., Spina, Celsa A., Richman, Douglas D.

“…In evaluating current combination drug regimens for treatment of human immunodeficiency virus (HIV) disease, it is important to determine the existence of…”
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The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes by SPINA, C. A, KWOH, T. J, CHOWERS, M. Y, GUTALLI, J. C, RICHMAN, D. D

“…The viral regulatory gene, nef, is unique to the human immunodeficiency viruses (HIV) and their related primate lentiviruses. Expression of the nef gene has…”
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Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene by CHOWERS, M. Y, SPINA, C. A, KWOH, T. J, FITCH, N. J. S, RICHMAN, D. D, GUATELLI, J. C

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Effect of Influenza Vaccination on Viral Replication and Immune Response in Persons Infected with Human Immunodeficiency Virus Receiving Potent Antiretroviral Therapy by Günthard, Huldrych F., Wong, Joseph K., Spina, Celsa A., Ignacio, Caroline, Kwok, Shirley, Christopherson, Cindy, Hwang, Jimmy, Haubrich, Richard, Havlir, Diane, Richman, Douglas D.

“…Nineteen patients infected with human immunodeficiency virus (HIV) with varying levels of viral suppression achieved with antiretroviral therapy were evaluated…”
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Establishment of a stable, inducible form of human immunodeficiency virus type 1 DNA in quiescent CD4 lymphocytes in vitro by Spina, C A, Guatelli, J C, Richman, D D

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Producer-cell modification of human immunodeficiency virus type 1: Nef is a virion protein by Pandori, M W, Fitch, N J, Craig, H M, Richman, D D, Spina, C A, Guatelli, J C

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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function by Appay, V, Nixon, D F, Donahoe, S M, Gillespie, G M, Dong, T, King, A, Ogg, G S, Spiegel, H M, Conlon, C, Spina, C A, Havlir, D V, Richman, D D, Waters, A, Easterbrook, P, McMichael, A J, Rowland-Jones, S L

“…The use of peptide-human histocompatibility leukocyte antigen (HLA) class I tetrameric complexes to identify antigen-specific CD8(+) T cells has provided a…”
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Inhibition of HIV replication by pokeweed antiviral protein targeted to CD4+ cells by monoclonal antibodies by Zarling, J.M, Moran, P.A, Haffar, O, Sias, J, Richman, D.D, Spina, C.A, Myers, D.E, Kuebelbeck, V, Ledbetter, J.A, Uckun, F.M

“…Functional impairment and selective depletion of CD4+ T cells, the hallmark of AIDS, are at least partly caused by human immunodeficiency virus (HIV-1) type I…”
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Viral dynamics of acute HIV-1 infection by Little, S J, McLean, A R, Spina, C A, Richman, D D, Havlir, D V

“…Viral dynamics were intensively investigated in eight patients with acute HIV infection to define the earliest rates of change in plasma HIV RNA before and…”
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Evolution of Envelope Sequences of Human Immunodeficiency Virus Type 1 in Cellular Reservoirs in the Setting of Potent Antiviral Therapy by Günthard, H F, Frost, S D, Leigh-Brown, A J, Ignacio, C C, Kee, K, Perelson, A S, Spina, C A, Havlir, D V, Hezareh, M, Looney, D J, Richman, D D, Wong, J K

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Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro by Spina, C A, Prince, H E, Richman, D D

“…The ability of HIV-1 to establish an infection and replicate to high copy number in CD4 lymphocytes is dependent on both the activation state of the cell and…”
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Alterations in cytotoxic and phenotypic subsets of natural killer cells in acquired immune deficiency syndrome (AIDS) by PLAEGER-MARSHALL, S, SPINA, C. A, GIORGI, J. V, MITSUYASU, R, WOLFE, P, GOTTLIEB, M, BEALL, G

“…Testing of cytotoxic function using a panel of natural killer (NK)-sensitive target cells, including a unique herpes simplex virus-infected Raji-cell target,…”
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In vitro differentiation of monocytoid THP-1 cells affects their permissiveness for HIV strains: a model system for studying the cellular basis of HIV differential tropism by Meylan, P R, Spina, C A, Richman, D D, Kornbluth, R S

“…The prototypic macrophage-tropic HIV-1 isolate, HIV-1BaL, cannot replicate in the monocytoid cell line THP-1. After induction of differentiation by a phorbol…”
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The use of three baseline values in intervention studies: application to evaluation of immune modulation therapies by Korn, E L, Dorey, F, Spina, C A, Fahey, J L

“…In studying the effects of a treatment intervention on immunological parameters, we have found that three baseline values are a practical number to obtain on…”
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Cell surface CD4 downregulation and resistance to superinfection induced by a defective provirus of HIV-1 by Little, S J, Riggs, N L, Chowers, M Y, Fitch, N J, Richman, D D, Spina, C A, Guatelli, J C

“…Proviral sequences encoding defective HIV-1 regulatory genes have been detected previously in infected individuals; however, the role of these defective…”
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Patient with 13 Chromosome Deletion: Evidence that the Retinoblastoma Gene is a Recessive Cancer Gene by Benedict, William F., Murphree, A. Linn, Banerjee, Ashutosh, Spina, Celsa A., Sparkes, Maryellen C., Sparkes, Robert S.

“…Although a constitutional chromosomal deletion including 13q14 has been found to date in all retinoblastoma patients whose esterase D activity is 50 percent of…”
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Depletion of latent HIV-1 infection in vivo: a proof-of-concept study by Lehrman, Ginger, Hogue, Ian B, Palmer, Sarah, Jennings, Cheryl, Spina, Celsa A, Wiegand, Ann, Landay, Alan L, Coombs, Robert W, Richman, Douglas D, Mellors, John W, Coffin, John M, Bosch, Ronald J, Margolis, David M

“…Persistent infection in resting CD4+ T cells prevents eradication of HIV-1. Since the chromatin remodeling enzyme histone deacetylase 1 (HDAC1) maintains…”
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Memory CD8 + T cells vary in differentiation phenotype in different persistent virus infections by Appay, Victor, Dunbar, P. Rod, Callan, Margaret, Klenerman, Paul, Gillespie, Geraldine M.A, Papagno, Laura, Ogg, Graham S, King, Abigail, Lechner, Franziska, Spina, Celsa A, Little, Susan, Havlir, Diane V, Richman, Douglas D, Gruener, Norbert, Pape, Gerd, Waters, Anele, Easterbrook, Philippa, Salio, Mariolina, Cerundolo, Vincenzo, McMichael, Andrew J, Rowland-Jones, Sarah L

“…The viruses HIV-1, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and hepatitis C virus (HCV) are characterized by the establishment of lifelong infection in…”
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Lymphocyte cytotoxicity in the peritoneal cavity and blood of patients with ovarian cancer by Berek, J S, Bast, Jr, R C, Lichtenstein, A, Hacker, N F, Spina, C A, Lagasse, L D, Knapp, R C, Zighelboim, J

“…After an intensive course of combination chemotherapy, 16 patients with minimal residual ovarian cancer that was documented at second-look laparotomy, had an…”
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