Search Results - "Spillings, Belinda L"
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Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions
Published in mBio (30-03-2021)“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2…”
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Protocol to quantify glycan-mediated binding between viral particles and human peripheral blood mononuclear cells using nanoluciferase
Published in STAR protocols (15-12-2023)“…Prior to receptor engagement, a specific, non-electrostatic glycan-glycan interaction between viral particles and host cells may lengthen the dwell time of the…”
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Protocol to visualize glycan-mediated binding between virus and human blood mononuclear cells using thin-section transmission electron microscopy
Published in STAR protocols (15-12-2023)“…Glycan-glycan interactions between viral particles and host cells may lengthen the dwell time of the virus on the cell surface to facilitate cellular receptor…”
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Complement Receptor 3 Mediates HIV-1 Transcytosis across an Intact Cervical Epithelial Cell Barrier: New Insight into HIV Transmission in Women
Published in mBio (22-02-2022)“…Transmission of HIV across the mucosal surface of the female reproductive tract to engage subepithelial CD4-positive T cells is not fully understood. Cervical…”
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Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2
Published in Clinical & translational immunology (2021)“…Objectives A major COVID‐19 vaccine strategy is to induce antibodies that prevent interaction between the Spike protein's receptor‐binding domain (RBD) and…”
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Calcium Contributes to Polarized Targeting of HIV Assembly Machinery by Regulating Complex Stability
Published in JACS Au (28-02-2022)“…Polarized or precision targeting of protein complexes to their destinations is fundamental to cellular homeostasis, but the mechanism underpinning directional…”
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The effect of a single blood meal on the phenotypic expression of insecticide resistance in the major malaria vector Anopheles funestus
Published in Malaria journal (31-10-2008)“…Anopheles funestus is a major malaria vector in southern Africa. Vector control relies on the use of insecticide chemicals to significantly reduce the number…”
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A comparison of DNA sequencing and the hydrolysis probe analysis (TaqMan assay) for knockdown resistance (kdr) mutations in Anopheles gambiae from the Republic of the Congo
Published in Malaria journal (12-10-2010)“…Knockdown resistance (kdr) caused by a single base pair mutation in the sodium channel gene is strongly associated with pyrethroid insecticide resistance in…”
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Host glycocalyx captures HIV proximal to the cell surface via oligomannose-GlcNAc glycan-glycan interactions to support viral entry
Published in Cell reports (Cambridge) (01-02-2022)“…Here, we present ultrastructural analyses showing that incoming HIV are captured near the lymphocyte surface in a virion-glycan-dependent manner. Biophysical…”
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Identification and characterization of microRNAs expressed in the African malaria vector Anopheles funestus life stages using high throughput sequencing
Published in Malaria journal (08-11-2016)“…Over the past several years, thousands of microRNAs (miRNAs) have been identified in the genomes of various insects through cloning and sequencing or even by…”
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A New Species Concealed by Anopheles funestus Giles, a Major Malaria Vector in Africa
Published in The American journal of tropical medicine and hygiene (01-09-2009)“…The major malaria vector Anopheles funestus belongs to a group of morphologically similar species that are commonly distinguished from one another through the…”
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Multiple insecticide resistance in Anopheles gambiae (Diptera: Culicidae) from Pointe Noire, Republic of the Congo
Published in Vector borne and zoonotic diseases (Larchmont, N.Y.) (01-08-2011)“…Successful implementation of an integrated vector control program will rely on availability of accurate vector information in the specific location. However,…”
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A comparison of DNA sequencing and the hydrolysis probe analysis mutations in Anopheles gambiae from the Republic of the Congo
Published in Malaria journal (12-10-2010)“…Background Knockdown resistance (kdr) caused by a single base pair mutation in the sodium channel gene is strongly associated with pyrethroid insecticide…”
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