Search Results - "Spiller, Cassy M."

Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse by Feng, Chun-Wei, Burnet, Guillaume, Spiller, Cassy M, Cheung, Fiona Ka Man, Chawengsaksophak, Kallayanee, Koopman, Peter, Bowles, Josephine

“…In mice, the entry of germ cells into meiosis crucially depends on the expression of stimulated by retinoic acid gene 8 ( ). is expressed specifically in…”
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Transcriptomic analysis of mRNA expression and alternative splicing during mouse sex determination by Zhao, Liang, Wang, Chenwei, Lehman, Melanie L., He, Mingyu, An, Jiyuan, Svingen, Terje, Spiller, Cassy M., Ng, Ee Ting, Nelson, Colleen C., Koopman, Peter

“…Mammalian sex determination hinges on sexually dimorphic transcriptional programs in developing fetal gonads. A comprehensive view of these programs is crucial…”
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Sex determination in mammalian germ cells by Spiller, Cassy M, Bowles, Josephine

“…Germ cells are the precursors of the sperm and oocytes and hence are critical for survival of the species. In mammals, they are specified during fetal life,…”
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Endogenous Nodal signaling regulates germ cell potency during mammalian testis development by Spiller, Cassy M, Feng, Chun-Wei, Jackson, Andrew, Gillis, Ad J M, Rolland, Antoine D, Looijenga, Leendert H J, Koopman, Peter, Bowles, Josephine

“…Germ cells, the embryonic precursors of sperm or oocytes, respond to molecular cues that regulate their sex-specific development in the fetal gonads. In males…”
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Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G₁/G₀ Arrest During Fetal Development in Mice by Spiller, Cassy M, Wilhelm, Dagmar, Koopman, Peter

“…During mouse germ cell development, the first sign of sex differentiation occurs when XY germ cells enter G₁/G₀ arrest from 12.5 days postcoitum (dpc)…”
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Mice Lacking Hbp1 Function Are Viable and Fertile by Spiller, Cassy M, Wilhelm, Dagmar, Jans, David A, Bowles, Josephine, Koopman, Peter

“…Fetal germ cell development is tightly regulated by the somatic cell environment, and is characterised by cell cycle states that differ between XY and XX…”
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AOP Key Event Relationship report: Linking decreased retinoic acid levels with disrupted meiosis in developing oocytes by Kam Draskau, Monica, Ravn Ballegaard, Anne-Sofie, Ramhøj, Louise, Bowles, Josephine, Svingen, Terje, Spiller, Cassy M.

“…[Display omitted] •The first case study to develop and publish an individual KER as a stand-alone unit of information under the AOP framework overseen by the…”
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Nodal/Cripto signaling in fetal male germ cell development: implications for testicular germ cell tumors by Spiller, Cassy M, Bowles, Josephine, Koopman, Peter

“…Testicular cancer is the most frequent cancer in young men aged 15-40 years and accounts for 1% of all cancer diagnosed in males. Testicular germ cell tumors…”
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Isolation and Culture Techniques for Fetal Mouse Germ Cells by Burnet, Guillaume, Bowles, Josephine, Spiller, Cassy M

“…The fetal gonad contains a great variety of differentiating cell populations, of which germ cells make up a relatively small percentage. In order to study germ…”
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Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation by Combes, Alexander N, Spiller, Cassy M, Harley, Vincent R, Sinclair, Andrew H, Dunwoodie, Sally L, Wilhelm, Dagmar, Koopman, Peter

“…Sex determination is regulated by a molecular antagonism between testis- and ovary-determining pathways in the supporting cell lineage of the gonadal…”
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Germ cell neoplasia in situ: The precursor cell for invasive germ cell tumors of the testis by Spiller, Cassy M., Bowles, Josephine

“…•GCNIS cells arise from blocked fetal germ cell differentiation.•GCNIS cells persist in the neonatal and adult testis in a dormant, non-proliferative…”
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Loss of Wnt5a Disrupts Primordial Germ Cell Migration and Male Sexual Development in Mice1 by Chawengsaksophak, Kallayanee, Svingen, Terje, Ng, Ee Ting, Epp, Trevor, Spiller, Cassy M, Clark, Charlotte, Cooper, Helen, Koopman, Peter

“…Disruptions in the regulatory pathways controlling sex determination and differentiation can cause disorders of sex development, often compromising…”
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Developmental biology meets toxicology: contributing reproductive mechanisms to build adverse outcome pathways by Draskau, Monica Kam, Spiller, Cassy M, Boberg, Julie, Bowles, Josephine, Svingen, Terje

“…Abstract An adverse outcome pathway (AOP) is a simplified description of the sequence of mechanistic events that lead to a particular toxicological effect,…”
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Perinatal exposure to environmental chemicals that disrupt thyroid function can perturb testis development by Draskau, Monica K., Strand, Ida W., Davila, Raul Ayala, Ballegaard, Anne-Sofie R., Pedersen, Mikael, Ramhøj, Louise, Rising, Sofie, Tran, Kieu-mi, Axelstad, Marta, Bowles, Josephine, Rosenmai, Anna K., Spiller, Cassy M., Svingen, Terje

“…Thyroid hormones (THs) are essential for normal growth and development. Their role in skeletal and brain development is well established, with congenital…”
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Mouse Fetal Germ Cell Isolation and Culture Techniques by Spiller, Cassy M, Burnet, Guillaume, Bowles, Josephine

“…The fetal gonad contains a great variety of differentiating cell populations, of which germ cells make up a small percentage. In order to study germ…”
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Retinoic Acid Antagonizes Testis Development in Mice by Bowles, Josephine, Feng, Chun-Wei, Ineson, Jessica, Miles, Kim, Spiller, Cassy M., Harley, Vincent R., Sinclair, Andrew H., Koopman, Peter

“…Mammalian sex determination depends on a complex interplay of signals that promote the bipotential fetal gonad to develop as either a testis or an ovary, but…”
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Generation and characterization of a Ddx4‐iCre transgenic line for deletion in the germline beginning at genital ridge colonization by Burnet, Guillaume, Feng, Chun‐Wei Allen, Cheung, Ka Man Fiona, Bowles, Josephine, Spiller, Cassy M.

“…Summary Germline‐specific Cre lines are useful for analyses of primordial germ cell, spermatogonial and oogonial development, but also for whole‐body deletions…”
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Loss of Wnt5a Disrupts Primordial Germ Cell Migration and Male Sexual Development in Mice by CHAWENGSAKSOPHAK, Kallayanee, SVINGEN, Terje, EE TING NG, EPP, Trevor, SPILLER, Cassy M, CLARK, Charlotte, COOPER, Helen, KOOPMAN, Peter

“…Disruptions in the regulatory pathways controlling sex determination and differentiation can cause disorders of sex development, often compromising…”
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Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa by Nixon, Brett, Paul, Jonathan W, Spiller, Cassy M, Attwell-Heap, Abigail G, Ashman, Leonie K, Aitken, R. John

“…Mammalian spermatozoa must become `capacitated' in the female reproductive tract before they gain the ability to fertilize the oocyte. The attainment of a…”
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Regulation of germ cell meiosis in the fetal ovary by Spiller, Cassy M, Bowles, Josephine, Koopman, Peter

“…Fertility depends on correct regulation of meiosis, the special form of cell division that gives rise to haploid gametes. In female mammals, germ cells enter…”
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