Search Results - "Spijker, Henri J"

Atom Transfer Radical Polymerization of Adenine, Thymine, Cytosine, and Guanine Nucleobase Monomers by Spijker, Henri J, van Delft, Floris L, van Hest, Jan C. M

“…Methacrylate monomers functionalized with thymine, adenine, cytosine, and guanine were prepared by alkylation of the nucleobases with 3-bromopropyl…”
Get full text

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 by Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H

“…Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and…”
Get full text

A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines by Coumans, Ruud G. E, Ariaans, Gerry J. A, Spijker, Henri J, Renart Verkerk, Pascal, Beusker, Patrick H, Kokke, Bas P. A, Schouten, Jan, Blomenröhr, Marion, van der Lee, Miranda M. C, Groothuis, Patrick G, Ubink, Ruud, Dokter, Wim H. A, Timmers, C. Marco

“…Engineering cysteines at specific sites in antibodies to create well-defined ADCs for the treatment of cancer is a promising approach to increase the…”
Get full text

Synthesis and assembly behavior of nucleobase-functionalized block copolymers by Spijker, Henri J., Dirks, A. J., van Hest, Jan C. M.

“…Block copolymers consisting of a poly(ethylene glycol) chain and a thymine‐ or adenine‐functional polymethacrylate block have been prepared with atom transfer…”
Get full text

Unusual rate enhancement in the thymine assisted ATRP process of adenine monomers by Spijker, Henri J., Dirks, A. (Ton) J., van Hest, Jan C.M.

“…Thymine and adenine monomers were synthesized and polymerized using ATRP in a controlled fashion. In addition a thymine functionalized block copolymer was…”
Get full text

Unusual rate enhancement in the thymine assisted ATRP process of adenine monomers : Controlled macromolecular synthesis and controlled architectures: Supramolecular polymer assemblies by SPIJKER, Henri J, DIRKS, A. J, VAN HEST, Jan C. M

Get full text