Search Results - "Spijker, Henri"

Design, Synthesis, and Evaluation of Linker-Duocarmycin Payloads: Toward Selection of HER2-Targeting Antibody–Drug Conjugate SYD985 by Elgersma, Ronald C, Coumans, Ruud G. E, Huijbregts, Tijl, Menge, Wiro M. P. B, Joosten, John A. F, Spijker, Henri J, de Groot, Franciscus M. H, van der Lee, Miranda M. C, Ubink, Ruud, van den Dobbelsteen, Diels J, Egging, David F, Dokter, Wim H. A, Verheijden, Gijs F. M, Lemmens, Jacques M, Timmers, C. Marco, Beusker, Patrick H

“…Antibody–drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and…”
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Preclinical profile of the HER2-targeting ADC SYD983/SYD985: introduction of a new duocarmycin-based linker-drug platform by Dokter, Wim, Ubink, Ruud, van der Lee, Miranda, van der Vleuten, Monique, van Achterberg, Tanja, Jacobs, Danielle, Loosveld, Eline, van den Dobbelsteen, Diels, Egging, David, Mattaar, Ellen, Groothuis, Patrick, Beusker, Patrick, Coumans, Ruud, Elgersma, Ronald, Menge, Wiro, Joosten, John, Spijker, Henri, Huijbregts, Tijl, de Groot, Vincent, Eppink, Michel, de Roo, Guy, Verheijden, Gijs, Timmers, Marco

“…A linker-drug platform was built on the basis of a cleavable linker-duocarmycin payload for the development of new-generation antibody-drug conjugates (ADC). A…”
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A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines by Coumans, Ruud G. E, Ariaans, Gerry J. A, Spijker, Henri J, Renart Verkerk, Pascal, Beusker, Patrick H, Kokke, Bas P. A, Schouten, Jan, Blomenröhr, Marion, van der Lee, Miranda M. C, Groothuis, Patrick G, Ubink, Ruud, Dokter, Wim H. A, Timmers, C. Marco

“…Engineering cysteines at specific sites in antibodies to create well-defined ADCs for the treatment of cancer is a promising approach to increase the…”
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Atom Transfer Radical Polymerization of Adenine, Thymine, Cytosine, and Guanine Nucleobase Monomers by Spijker, Henri J, van Delft, Floris L, van Hest, Jan C. M

“…Methacrylate monomers functionalized with thymine, adenine, cytosine, and guanine were prepared by alkylation of the nucleobases with 3-bromopropyl…”
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Synthesis and assembly behavior of nucleobase-functionalized block copolymers by Spijker, Henri J., Dirks, A. J., van Hest, Jan C. M.

“…Block copolymers consisting of a poly(ethylene glycol) chain and a thymine‐ or adenine‐functional polymethacrylate block have been prepared with atom transfer…”
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Abstract 4640: Development of antibody-drug conjugate technology based on novel DNA-interacting agents and unique linker technology by De Groot, Vincent F.M.H., Beusker, Patrick, Joosten, John, Spijker, Henri, Coumans, Ruud, Menge, Wiro, Elgersma, Ronald

“…Abstract Antibody-Drug Conjugation (ADC) is gaining momentum as a next generation antibody therapeutics approach in oncology. Tumor specific delivery of the…”
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Abstract 4397: Development of antibody-drug conjugate technology based on novel linkers & DNA alkylating duocarmycin derivatives by de Groot, Vincent F.M.H, Beusker, Patrick, Joosten, John, Spijker, Henri, Coumans, Ruud, Menge, Wiro, Elgersma, Ronald

“…Abstract Antibody-Drug Conjugation (ADC) is gaining momentum as a next generation antibody therapeutics approach in oncology. Tumor specific delivery of the…”
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Unusual rate enhancement in the thymine assisted ATRP process of adenine monomers by Spijker, Henri J., Dirks, A. (Ton) J., van Hest, Jan C.M.

“…Thymine and adenine monomers were synthesized and polymerized using ATRP in a controlled fashion. In addition a thymine functionalized block copolymer was…”
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Unusual rate enhancement in the thymine assisted ATRP process of adenine monomers : Controlled macromolecular synthesis and controlled architectures: Supramolecular polymer assemblies by SPIJKER, Henri J, DIRKS, A. J, VAN HEST, Jan C. M

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