The pattern of myelin proteins in triethyltin (TET) intoxication

Myelin proteins isolated from the brain of Wistar rats intoxicated chronically with triethyltin sulfate (TET) according to the technique of ETO et al. (1971) were investigated. Among the various protein fractions, the Agraval protein happened to be most evidently affected, demonstrating considerably...

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Bibliographic Details
Published in:	Experimental pathology (1981) Vol. 23; no. 3; p. 193
Main Authors:	Wender, M, Zgorzalewicz, B, Piechowski, A, Spieszalski, W, Bucholc, M
Format:	Journal Article
Language:	English
Published:	Germany 1983
Subjects:	Animals Myelin Basic Protein - analysis Myelin Proteins - analysis Myelin Sheath - analysis Myelin Sheath - pathology Nerve Fibers, Myelinated - pathology Optic Nerve - analysis Optic Nerve - pathology Rats Rats, Inbred Strains Trialkyltin Compounds - poisoning Triethyltin Compounds - poisoning Vacuoles - ultrastructure
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Summary:	Myelin proteins isolated from the brain of Wistar rats intoxicated chronically with triethyltin sulfate (TET) according to the technique of ETO et al. (1971) were investigated. Among the various protein fractions, the Agraval protein happened to be most evidently affected, demonstrating considerably reduced percentages. However the results did not prove that any of the individual myelin proteins was specifically affected by TET intake. The interesting point in chronic TET poisoning was that some clinical symptoms as well as disturbances in myelin proteins demonstrated a clear tendency to retrogression despite of the continued intoxication. These observations indicate obviously that during chronic TET intake, some kind of biochemical adaptation to the noxious action of the poison on the myelin sheath takes place.
ISSN:	0232-1513
DOI:	10.1016/S0232-1513(83)80057-7