Search Results - "Spiess, Joachim"

Modulation of Learning and Anxiety by Corticotropin-Releasing Factor (CRF) and Stress: Differential Roles of CRF Receptors 1 and 2 by Radulovic, Jelena, Ruhmann, Andreas, Liepold, Thomas, Spiess, Joachim

“…The differential modulation of learning and anxiety by corticotropin-releasing factor (CRF) through CRF receptor subtypes 1 (CRFR1) and 2 (CRFR2) is…”
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Time-dependent involvement of the dorsal hippocampus in trace fear conditioning in mice by Misane, Ilga, Tovote, Philip, Meyer, Michael, Spiess, Joachim, Ögren, Sven Ove, Stiedl, Oliver

“…Hippocampal and amygdaloid neuroplasticity are important substrates for Pavlovian fear conditioning. The hippocampus has been implicated in trace fear…”
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Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2 by Radulovic, Marko, Rosenfeld, Michael G, Spiess, Joachim, Kishimoto, Toshimitsu, Radulovic, Jelena, Lin, Chijen R, Schrick, Christina, Hooshmand, Farideh, Hermanson, Ola

“…Corticotropin-releasing hormone (Crh), a 41-residue polypeptide, activates two G-protein-coupled receptors, Crhr1 (refs 3-5) and Crhr2 (refs 6-9), causing…”
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Corticotropin-releasing factor receptors and urocortins, links between the brain and the heart by Yang, Li-Zhen, Tovote, Philip, Rayner, Martin, Kockskämper, Jens, Pieske, Burkert, Spiess, Joachim

“…Corticotropin-releasing factor (CRF), a 41 amino acid peptide, was discovered as a key signal in mediating neuroendocrine, autonomic, and behavioral responses…”
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Relationship between Fos Production and Classical Fear Conditioning: Effects of Novelty, Latent Inhibition, and Unconditioned Stimulus Preexposure by Radulovic, Jelena, Kammermeier, Jens, Spiess, Joachim

“…The relationship between FOS production in the sensory cortex and limbic system and the ability of C57BL/6N mice to acquire context- and tone-dependent…”
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Corticotropin-Releasing Factor Receptors Couple to Multiple G-Proteins to Activate Diverse Intracellular Signaling Pathways in Mouse Hippocampus: Role in Neuronal Excitability and Associative Learning by Blank, Thomas, Nijholt, Ingrid, Grammatopoulos, Dimitris K, Randeva, Harpal S, Hillhouse, Edward W, Spiess, Joachim

“…Corticotropin-releasing factor (CRF) exerts a key neuroregulatory control on stress responses in various regions of the mammalian brain, including the…”
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Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits by Blank, Thomas, Nijholt, Ingrid, Kye, Min-Jeong, Radulovic, Jelena, Spiess, Joachim

“…Cognitive deficits are among the most devastating changes associated with the aging process. Age-related decrement in performance on learning tasks is…”
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Urocortin 1 and Urocortin 2 induce macrophage apoptosis via CRFR2 by Tsatsanis, Christos, Androulidaki, Ariadne, Dermitzaki, Erini, Charalampopoulos, Ioannis, Spiess, Joachim, Gravanis, Achille, Margioris, Andrew N.

“…Macrophages undergo apoptosis as a mechanism of regulating their activation and the inflammatory reaction. Macrophages express the Corticotropin-Releasing…”
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cAMP‐ and Ca2+/calmodulin‐dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes by Yang, Li‐Zhen, Kockskämper, Jens, Khan, Shelina, Suarez, Jorge, Walther, Stefanie, Doleschal, Bernhard, Unterer, Gregor, Khafaga, Mounir, Mächler, Heinrich, Heinzel, Frank R., Dillmann, Wolfgang H., Pieske, Burkert, Spiess, Joachim

“…BACKGROUND AND PURPOSE Urocortin 2 is beneficial in heart failure, but the underlying cellular mechanisms are not completely understood. Here we have…”
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Transcriptional regulation of intronic calcium-activated potassium channel SK2 promoters by nuclear factor-kappa B and glucocorticoids by Kye, Min-Jeong, Spiess, Joachim, Blank, Thomas

“…Small-conductance Ca²⁺-activated K⁺ channels (SK) of the SK2 subtype are widely expressed in the central nervous system where they contribute to the control of…”
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Cortagine, a Specific Agonist of Corticotropin-Releasing Factor Receptor Subtype 1, Is Anxiogenic and Antidepressive in the Mouse Model by Tezval, Hossein, Jahn, Olaf, Todorovic, Cedomir, Sasse, Astrid, Eckart, Klaus, Spiess, Joachim, Rosenfeld, Michael G.

“…Two subtypes of the corticotropin-releasing factor (CRF) receptor, CRF1and CRF2, differentially modulate brain functions such as anxiety and memory. To…”
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Cholecystokinin-2 (CCK2) receptor-mediated anxiety-like behaviors in rats by Wang, Hong, Wong, Peter T.-H., Spiess, Joachim, Zhu, Yi Zhun

“…Cholecystokinin (CCK) is a neurotransmitter in the brain closely related to anxiety. Of the two CCK receptor subtypes, CCK2 receptors are most implicated in…”
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In vivo 3D MRI staining of the mouse hippocampal system using intracerebral injection of MnCl2 by Watanabe, Takashi, Radulovic, Jelena, Spiess, Joachim, Natt, Oliver, Boretius, Susann, Frahm, Jens, Michaelis, Thomas

“…The morphology and function of the hippocampal system of C57BL/6J mice (n = 8) was studied in vivo using T1-weighted 3D magnetic resonance imaging (MRI) (117…”
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Structural Requirements for Peptidic Antagonists of the Corticotropin-Releasing Factor Receptor (CRFR): Development of CRFR2β -selective Antisauvagine-30 by Ruhmann, Andreas, Bonk, Ines, Lin, Chijen R., Rosenfeld, Michael G., Spiess, Joachim

“…Different truncated and conformationally constrained analogs of corticotropin-releasing factor (CRF) were synthesized on the basis of the amino acid sequences…”
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Impairment of conditioned contextual fear of C57BL/6J mice by intracerebral injections of the NMDA receptor antagonist APV by Stiedl, Oliver, Birkenfeld, Karin, Palve, Markki, Spiess, Joachim

“…The effects of acute injections of the NMDA receptor antagonist APV on one-trial fear conditioning of C57BL/6J mice were investigated in a time, dose (0.4–3.2…”
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Generalization of fear responses in C57BL/6N mice subjected to one-trial foreground contextual fear conditioning by Radulovic, Jelena, Kammermeier, Jens, Spiess, Joachim

“…C57BL/6N mice were trained in a foreground contextual fear conditioning paradigm by a single exposure to a context (context 1) paired with an electric shock…”
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The role of CRF receptors in anxiety and depression: Implications of the novel CRF1 agonist cortagine by Todorovic, Cedomir, Jahn, Olaf, Tezval, Hossein, Hippel, Cathrin, Spiess, Joachim

“…Corticotropin-releasing factor (CRF), a 41 amino acid peptide exhibits its actions through two pharmacologically distinct CRF receptor subtypes CRF1 and CRF2…”
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Corticotropin-releasing factor receptor 1 and central heart rate regulation in mice during expression of conditioned fear by Stiedl, Oliver, Meyer, Michael, Jahn, Olaf, Ogren, Sven Ove, Spiess, Joachim

“…The present study was performed to 1) determine heart rate (HR) effects mediated through central corticotropin-releasing factor receptor subtypes 1 (CRF(1))…”
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Production of the Fos protein after contextual fear conditioning of C57BL/6N mice by Milanovic, Snezana, Radulovic, Jelena, Laban, Olgica, Stiedl, Oliver, Henn, Fritz, Spiess, Joachim

“…Male C57BL/6N mice were chosen to determine Fos production during acquisition of context-dependent fear and after re-exposure to the conditioning context…”
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Effect of Tone-Dependent Fear Conditioning on Heart Rate and Behavior of C57BL/6N Mice by Stiedl, Oliver, Spiess, Joachim

“…The effects of the temporal sequence of tone (conditioned stimulus [CS]) and footshock (unconditioned stimulus [US]) during training (acquisition) on…”
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