Search Results - "Spiers, JP"

The relationship between the MMP system, adrenoceptors and phosphoprotein phosphatases by Rietz, A, Spiers, JP

“…The MMPs and their inhibitors [tissue inhibitor of MMPs (TIMPs) ] form the mainstay of extracellular matrix homeostasis. They are expressed in response to…”
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Differential interactions of antiretroviral agents with LXR, ER and GR nuclear receptors: potential contributing factors to adverse events by Svärd, J, Blanco, F, Nevin, D, Fayne, D, Mulcahy, F, Hennessy, M, Spiers, J P

“…Background and Purpose Antiretroviral (ARV) drugs activate pregnane X receptors and constitutive androstane receptors, increasing the risk of drug interactions…”
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St John's Wort increases expression of P‐glycoprotein: Implications for drug interactions by Hennessy, M., Kelleher, D., Spiers, J. P., Barry, M., Kavanagh, P., Back, D., Mulcahy, F., Feely, J.

“…Aims  St John's Wort (SJW) is widely used in the treatment of depression but concerns have been raised about its potential to interact with other drugs…”
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Okadaic acid induces matrix metalloproteinase-9 expression in fibroblasts: crosstalk between protein phosphatase inhibition and [beta]-adrenoceptor signalling by Rietz, A, Volkov, Y, Davies, A, Hennessy, M, Spiers, JP

“…BACKGROUND AND PURPOSE Interactions between protein phosphatase inhibition and matrix metalloproteinase (MMP)-9 expression have implications for tissue…”
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Okadaic acid induces matrix metalloproteinase‐9 expression in fibroblasts: crosstalk between protein phosphatase inhibition and β‐adrenoceptor signalling by Rietz, A, Volkov, Y, Davies, A, Hennessy, M, Spiers, JP

“…BACKGROUND AND PURPOSE Interactions between protein phosphatase inhibition and matrix metalloproteinase (MMP)‐9 expression have implications for tissue…”
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Alterations in vascular matrix metalloproteinase due to ageing and chronic hypertension : effects of endothelin receptor blockade by SPIERS, James P, KELSO, Elizabeth J, SIAH, Wei F, EDGE, Gillian, GUOJIE SONG, MCDERMOTT, Barbara J, HENNESSY, Martina

“…To determine the effects of age and dual endothelin (ET)A/ETB receptor antagonism (bosentan) on aortic matrix metalloproteinase (MMP) abundance and tissue…”
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Antivirals and nuclear receptor activation of CYP3A4 and 2B6 by Svard, J, Spiers, JP, Mulcahy, F, Hennessy, M

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Intracellular accumulation of nelfinavir and its relationship to P-glycoprotein expression and function in HIV-infected patients by HENNESSY, Martina, CLARKE, Susan, SPIERS, J. Paul, KELLEHER, Dermot, MULCAHY, Fiona, HOGGARD, Patrick, BACK, David, BARRY, Michael

“…To compare plasma and intracellular nelfinavir pharmacokinetics, and determine their relationship to P-glycoprotein (P-gp) expression and function in…”
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Protease inhibitor-induced cardiotoxicity: direct effects on cell viability and intracellular calcium levels by Spiers, JP, Edwards, C, Rietz, A, Jan, E, Mulcahy, F, Hennessy, M, Volkov, Y, Davies, AM

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Endothelin(A) receptor subtype mediates endothelin-induced contractility in left ventricular cardiomyocytes isolated from rabbit myocardium by Kelso, E J, McDermott, B J, Silke, B, Spiers, J P

“…Endothelin (ET)-1 is a potent positive inotropic agent, the effects of which are mediated by increases in cytosolic Ca(2+) in the myocardium. The object of…”
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Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics by HENNESSY, Martina, CLARKE, Susan, HAGGARD, Patrick, BACK, David, BARRY, Michael, SPIERS, J. Paul, MULCAHY, Fiona, KELLEHER, Dermot, MEADON, Emma, MAHER, Bridget, BERGIN, Colm, KHOO, Saye, TJIA, John

“…To determine intracellular concentrations of indinavir (IDV) and investigate the relationship between plasma and intracellular IDV pharmacokinetics in…”
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Inotropic response to endothelin‐1, isoprenaline and calcium in cardiomyocytes isolated from endotoxin treated rats: effects of ethyl‐isothiourea and dexamethasone by Spiers, J P, Kelso, E J, Allen, J D, Silke, B, McDermott, B J

“…The contractile effects of endothelin‐1, isoprenaline and extracellular calcium were assessed on ventricular cardiomyocytes isolated from…”
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Myocardial Expression of the Endothelin System in Endotoxin- Treated Rats by Spiers, James Paul, Dorman, Alastair, Allen, John Desmond, Kelso, Elizabeth Jane, Silke, Bernard, McDermott, Barbara Jean

“…Although circulating plasma levels of endothelin (ET)-1 are elevated in endotoxemia, little is known about the myocardial expression of the ET system in…”
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Receptor-mediated effects of endothelin on the L-type Ca++ current in ventricular cardiomyocytes by Kelso, E J, Spiers, J P, McDermott, B J, Scholfield, C N, Silke, B

“…The purpose of this study was to establish whether specific receptor subtypes are responsible for mediating the effects of endothelin-1 (ET-1) and endothelin-3…”
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Stimulation of L-type Ca2+ current by the endothelin receptor A-selective antagonist, BQ-123, in ventricular cardiomyocytes isolated from rabbit myocardium by KELSO, E. J, SPIERS, J. P, MCDERMOTT, B. J, SCHOLFIELD, C. N, SILKE, B

“…BQ-123 is extensively used as an antagonist at endothelin (ET) receptors, having selectivity at the ET(A) receptor subtype. In this study, the effects of…”
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Endothelin‐1 mediated inhibition of the acetylcholine‐activated potassium current from rabbit isolated atrial cardiomyocytes by Spiers, J. Paul, Kelso, Elizabeth J., McDermott, Barbara J., Scholfield, C. Norman, Silke, Bernard

“…1 Endothelin‐1 is a 21 amino acid peptide with potent inotropic and chronotropic actions in the heart. Relatively little is known about the underlying…”
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Acute and chronic effects of rilmenidine on baroreflex function in conscious dogs by Spiers, J P, Harron, D W, Wilson, R

“…The effects of acute and chronic administration of rilmenidine on blood pressure, heart rate and baroreflex function were assessed in two groups of six…”
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UK-52,046 (a novel alpha 1-adrenoceptor antagonist) and the role of alpha-adrenoceptor stimulation and blockade on atrioventricular conduction by Spiers, J P, Harron, D W, Wilson, R, Allen, J D

“…The effects of increasing intravenous (i.v.) doses of prazosin, phenylephrine, flecainide, and UK-52,046 on blood pressure (BP), heart rate (HR) and the…”
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Resuscitation of hemorrhagic shock with hypertonic saline/dextran or lactated Ringer's supplemented with AICA riboside by Spiers, J P, Fabian, T C, Kudsk, K A, Proctor, K G

“…Anesthetized and ventilated swine were bled 23 ml/kg (34% of calculated blood volume) to a mean arterial pressure < 50 mm Hg. After 60 min, a bolus of either…”
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