Path integration following temporal lobectomy in humans

Path integration following temporal lobectomy in humans

Path integration, a component of spatial navigation, is the process used to determine position information on the basis of information about distance and direction travelled derived from self-motion cues. Following on from studies in the animal literature that seem to support the role of the hippoca...

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Bibliographic Details
Published in:Neuropsychologia Vol. 39; no. 5; pp. 452 - 464
Main Authors: Worsley, Claire L, Recce, Michael, Spiers, Hugo Jo, Marley, Justin, Polkey, Charles Eo, Morris, Robin G
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 01-01-2001
Elsevier Science
Subjects:
Adult
Adult and adolescent clinical studies
Biological and medical sciences
Dead reckoning
Female
Humans
Locomotion
Male
Medical sciences
Memory
Mental Processes
Middle Aged
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Space Perception
Spatial memory
Spatial navigation
Temporal Lobe - physiology
Temporal Lobe - surgery
Temporal lobes
Temporal lobes
Spatial navigation
Dead reckoning
Spatial memory
Human
Temporal lobe
Memory disorder
Nervous system diseases
Navigation
Cognitive disorder
Temporal lobectomy
Central nervous system disease
Spatial orientation
Laterality
Cerebral disorder
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Summary:Path integration, a component of spatial navigation, is the process used to determine position information on the basis of information about distance and direction travelled derived from self-motion cues. Following on from studies in the animal literature that seem to support the role of the hippocampal formation in path integration, this facility was investigated in humans with focal brain lesions. Thirty-three neurosurgical patients (17 left temporal lobectomy, LTL; 16 right temporal lobectomy, RTL) and 16 controls were tested on a number of blindfolded tasks designed to investigate path integration and on a number of additional control tasks (assessing mental rotation and left–right orientation). In a test of the ability to compute a homing vector, the subjects had to return to the start after being led along a route consisting of two distances and one turn. Patients with RTL only were impaired at estimating the turn required to return to the start. On a second task, route reproduction was tested by requiring the subjects to reproduce a route consisting of two distances and one turn; the RTL group only were also impaired at reproducing the turn, but this impairment did not correlate with the homing vector deficit. There were no group differences on tasks where subjects were required to reproduce a single distance or a single turn. The results indicate that path integration is impaired in RTL patients only and suggest that the right temporal lobe plays a role in idiothetic spatial memory.
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ISSN:0028-3932
1873-3514
DOI:10.1016/S0028-3932(00)00140-8