Search Results - "Spiera, R."

Clinical Outcomes of Remission Induction Therapy for Severe Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Miloslavsky, E. M., Specks, U., Merkel, P. A., Seo, P., Spiera, R., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St.Clair, E. W., Tchao, N. K., Viviano, L., Ding, L., Sejismundo, L. P., Mieras, K., Iklé, D., Jepson, B., Mueller, M., Brunetta, P., Allen, N. B., Fervenza, F. C., Geetha, D., Keogh, K., Kissin, E. Y., Monach, P. A., Peikert, T., Stegeman, C., Ytterberg, S. R., Stone, J. H.

“…Objective To evaluate the reasons that complete remission is not achieved or maintained with original treatment in some patients with antineutrophil…”
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Rituximab for the Treatment of Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Miloslavsky, E. M., Specks, U., Merkel, P. A., Seo, P., Spiera, R., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St.Clair, E. W., Tchao, N. K., Viviano, L., Ding, L., Iklé, D., Villarreal, M., Jepson, B., Brunetta, P., Allen, N. B., Fervenza, F. C., Geetha, D., Keogh, K., Kissin, E. Y., Monach, P. A., Peikert, T., Stegeman, C., Ytterberg, S. R., Stone, J. H.

“…Objective Disease relapses are frequent in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). This study was undertaken to evaluate outcomes in…”
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Outcomes of Nonsevere Relapses in Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Treated With Glucocorticoids by Miloslavsky, E. M., Specks, U., Merkel, P. A., Seo, P., Spiera, R., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St.Clair, E. W., Tchao, N. K., Ding, L., Iklé, D., Villareal, M., Lim, N., Brunetta, P., Fervenza, F. C., Monach, P. A., Stone, J. H.

“…Objective Nonsevere relapses are more common than severe relapses in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV), but their clinical…”
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A prospective, double-blind, randomized, placebo controlled trial of methotrexate in the treatment of giant cell arteritis (GCA) by SPIERA, R. F, MITNICK, H. J, KUPERSMITH, M, RICHMOND, M, SPIERA, H, PETERSON, M. G. E, PAGET, S. A

“…To determine if methotrexate has disease-controlling and corticosteroid (cs)-sparing effects in the treatment of giant cell arteritis (GCA). This was a…”
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Immunoglobulin (Ig)M antibodies to proteinase 3 in granulomatosis with polyangiitis and microscopic polyangiitis by Clain, J. M., Hummel, A. M., Stone, J. H., Fervenza, F. C., Hoffman, G. S., Kallenberg, C. G. M., Langford, C. A., McCune, W. J., Merkel, P. A., Monach, P. A., Seo, P., Spiera, R. F., St Clair, E. W., Ytterberg, S. R., Specks, U.

“…Summary Anti‐neutrophil cytoplasmic antibodies (ANCA) appear to play an important role in the pathogenesis of ANCA‐associated vasculitis (AAV). However, ANCA…”
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Silicone gel filled breast implants and connective tissue disease: an overview by Spiera, R F, Gibofsky, A, Spiera, H

“…To review the literature examining the association of silicone gel filled implants and connective tissue disease. Computerized literature searches and manual…”
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Glycosylation of proteinase 3 (PR3) is not required for its reactivity with antineutrophil cytoplasmic antibodies (ANCA) in Wegener's granulomatosis by Finkielman, J D, Merkel, P A, Schroeder, D, Hoffman, G S, Spiera, R, St Clair, E W, Davis, Jr, J C, McCune, W J, Lears, A, Ytterberg, S R, Hummel, A M, Viss, M A, Peikert, T, Stone, J H, Specks, U

“…The glycosylation status of autoantigens appears to be crucial for the pathogenesis of some autoimmune diseases, since carbohydrates play a crucial role in the…”
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Trial of Tocilizumab in Giant-Cell Arteritis by Stone, John H, Tuckwell, Katie, Dimonaco, Sophie, Klearman, Micki, Aringer, Martin, Blockmans, Daniel, Brouwer, Elisabeth, Cid, Maria C, Dasgupta, Bhaskar, Rech, Juergen, Salvarani, Carlo, Schett, Georg, Schulze-Koops, Hendrik, Spiera, Robert, Unizony, Sebastian H, Collinson, Neil

“…Treatment of giant-cell arteritis with tocilizumab, an interleukin-6 receptor alpha inhibitor, while prednisone was tapered over a 26-week period resulted in…”
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Brief Report: A Prospective Open‐Label Phase IIa Trial of Tocilizumab in the Treatment of Polymyalgia Rheumatica by Lally, Lindsay, Forbess, Lindsy, Hatzis, Christopher, Spiera, Robert

“…Objective Interleukin‐6 (IL‐6) is a pivotal cytokine in the pathogenesis of polymyalgia rheumatica (PMR), yet the efficacy of IL‐6 blockade with tocilizumab…”
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Visual performance in giant cell arteritis (temporal arteritis) after 1 year of therapy by Kupersmith, Mark J, Langer, Regina, Mitnick, Hal, Spiera, Robert, Spiera, Harry, Richmond, Marjorie, Paget, Stephen

“…AIMS To determine if patients with giant cell arteritis (GCA) treated with corticosteroids develop delayed visual loss or drug related ocular complications…”
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Sleep-Related Hypoxia, Right Ventricular Dysfunction, and Survival in Patients With Group 1 Pulmonary Arterial Hypertension by Lowery, Megan M, Hill, Nicholas S, Wang, Lu, Rosenzweig, Erika B, Bhat, Aparna, Erzurum, Serpil, Finet, J Emanuel, Jellis, Christine L, Kaur, Sunjeet, Kwon, Deborah H, Nawabit, Rawan, Radeva, Milena, Beck, Gerald J, Frantz, Robert P, Hassoun, Paul M, Hemnes, Anna R, Horn, Evelyn M, Leopold, Jane A, Rischard, Franz P, Mehra, Reena

“…Group 1 pulmonary arterial hypertension (PAH) is a progressive fatal condition characterized by right ventricular (RV) failure with worse outcomes in…”
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Methotrexate in giant-cell arteritis by Morgan, S L, Alarcón, G S

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A randomised, double-blind, placebo-controlled phase 3 study of lenabasum in diffuse cutaneous systemic sclerosis: RESOLVE-1 design and rationale by Spiera, Robert, Khanna, Dinesh, Kuwana, Masataka, Furst, Daniel E, Frech, Tracy M, Hummers, Laura, Stevens, Wendy, Matucci-Cerinic, Marco, Baron, Murray, Distler, Oliver, Dgetluck, Nancy, Bloom, Bradley J, Dinh, Quinn, White, Barbara, Denton, Christopher P

“…The multi-systemic, heterogenous nature of diffuse cutaneous systemic sclerosis (dcSSc) presents challenges in designing clinical studies that can demonstrate…”
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Integration of capillary microscopy and dermoscopy into the rheumatology fellow curriculum by Hatzis, Christopher, Lerner, Daniele, Paget, Stephen, Cutolo, Maurizio, Smith, Vanessa, Spiera, Robert, Gordon, Jessica

“…This study evaluates a novel, three-part nailfold capillaroscopy training curriculum for adult and paediatric rheumatology fellows. All rheumatology fellows…”
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Etanercept plus Standard Therapy for Wegener's Granulomatosis by Wegener's Granulomatosis Etanercept Trial (WGET) Research Group

“…This randomized trial examined the effect of adding etanercept to standard therapy in order to maintain disease remissions in patients with Wegener's…”
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Increased rho kinase activity in temporal artery biopsies from patients with giant cell arteritis by Lally, Lindsay, Pernis, Alessandra, Narula, Navneet, Huang, Wei-Ti, Spiera, Robert

“…Aberrant rho kinase (ROCK) activity is implicated in the pathogenesis of several vascular diseases and is associated with Th17 differentiation. Th17 immune…”
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Methotrexate in giant-cell arteritis by Spiera, R F, Paget, S, Spiera, H

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Randomised, double-blind, placebo-controlled trial of IL1-trap, rilonacept, in systemic sclerosis. A phase I/II biomarker trial by Mantero, Julio C, Kishore, Nina, Ziemek, Jessica, Stifano, Giuseppina, Zammitti, Christopher, Khanna, Dinesh, Gordon, Jessica K, Spiera, Robert, Zhang, Yuqing, Simms, Robert W, Lafyatis, Robert

“…This clinical trial was designed to study the safety and efficacy of blocking IL-1 in skin fibrosis of patients with diffuse cutaneous systemic sclerosis…”
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Brief Communication: High Incidence of Venous Thrombotic Events among Patients with Wegener Granulomatosis: The Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study by Merkel, Peter A., Lo, Grace H., Holbrook, Janet T., Tibbs, Andrea K., Allen, Nancy B., Davis, John C., Hoffman, Gary S., McCune, W. Joseph, St. Clair, E. William, Specks, Ulrich, Spiera, Robert, Petri, Michelle, Stone, John H.

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P12. Increased rho kinase (ROCK) activity in temporal arterial biopsies from patients with giant cell arteritis by Lally, L., Narula, N., Pernis, A. B., Huang, W.-T., Udeh, U., Spiera, R. F.

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