Search Results - "Spiegelman, George"

The world of subinhibitory antibiotic concentrations by Davies, Julian, Spiegelman, George B, Yim, Grace

“…Although antibiotics have long been known to have multiple effects on bacterial cells at low concentrations, it is only with the advent of genome transcription…”
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The mycobacterial antibiotic resistance determinant WhiB7 acts as a transcriptional activator by binding the primary sigma factor SigA (RpoV) by Burian, Ján, Yim, Grace, Hsing, Michael, Axerio-Cilies, Peter, Cherkasov, Artem, Spiegelman, George B, Thompson, Charles J

“…Tuberculosis therapeutic options are limited by the high intrinsic antibiotic resistance of Mycobacterium tuberculosis. The putative transcriptional regulator…”
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Delineation of the roles played by RasG and RasC in cAMP-dependent signal transduction during the early development of Dictyostelium discoideum by Bolourani, Parvin, Spiegelman, George B, Weeks, Gerald

“…On starvation, the cellular slime mold Dictyostelium discoideum initiates a program of development leading to formation of multicellular structures. The…”
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The genetic core of the universal ancestor by Harris, J Kirk, Kelley, Scott T, Spiegelman, George B, Pace, Norman R

“…Molecular analysis of conserved sequences in the ribosomal RNAs of modern organisms reveals a three-domain phylogeny that converges in a universal ancestor for…”
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Ras Proteins Have Multiple Functions in Vegetative Cells of Dictyostelium by Bolourani, Parvin, Spiegelman, George, Weeks, Gerald

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Transcription Modulation of Salmonella enterica Serovar Typhimurium Promoters by Sub-MIC Levels of Rifampin by YIM, Grace, DE LA CRUZ, Fernando, SPIEGELMAN, George B, DAVIES, Julian

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Rap1 Activation in Response to cAMP Occurs Downstream of Ras Activation during Dictyostelium Aggregation by Bolourani, Parvin, Spiegelman, George B., Weeks, Gerald

“…We have used a doubly disrupted rasC–/rasG– strain of Dictyostelium discoideum, which ectopically expresses the carA gene, to explore the relationship between…”
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Separate mechanisms are involved in rifampicin upmodulated and downmodulated gene expression in Salmonella Typhimurium by Yim, Grace, Spiegelman, George B., Davies, Julian E.

“…Sub-MIC antibiotics differentially modulate transcription of subsets of genes by unknown mechanisms. Paradoxically, the RNA polymerase inhibitor rifampicin is…”
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Chemoattractant-induced Ras activation during Dictyostelium aggregation by Kae, Helmut, Lim, Chinten James, Spiegelman, George B, Weeks, Gerald

“…Ras proteins are highly conserved molecular switches that regulate cellular response to external stimuli. Dictyostelium discoideum contains an extensive family…”
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Culture-Independent Molecular Analysis of Microbial Constituents of the Healthy Human Outer Ear by FRANK, Daniel N, SPIEGELMAN, George B, DAVIS, William, WAGNER, Eileen, LYONS, Eric, PACE, Norman R

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An A257V Mutation in the Bacillus subtilis Response Regulator Spo0A Prevents Regulated Expression of Promoters with Low-Consensus Binding Sites by SEREDICK, Steve D, SEREDIEK, Barbara M, BAKER, David, SPIEGELMAN, George B

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Cyclic AMP signalling in Dictyostelium: G-proteins activate separate Ras pathways using specific RasGEFs by Kae, Helmut, Kortholt, Arjan, Rehmann, Holger, Insall, Robert H, Van Haastert, Peter J M, Spiegelman, George B, Weeks, Gerald

“…In general, mammalian Ras guanine nucleotide exchange factors (RasGEFs) show little substrate specificity, although they are often thought to regulate specific…”
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Roles played by Ras subfamily proteins in the cell and developmental biology of microorganisms by Weeks, Gerald, Spiegelman, George B.

“…The Ras subfamily proteins are monomeric GTPases that function as molecular switches in cellular signal transduction pathways. This review describes our…”
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Using Invention to Change How Students Tackle Problems by Taylor, Jared L, Smith, Karen M, van Stolk, Adrian P, Spiegelman, George B

“…Invention activities challenge students to tackle problems that superficially appear unrelated to the course material but illustrate underlying fundamental…”
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RasC is required for optimal activation of adenylyl cyclase and Akt/PKB during aggregation by Lim, Chinten James, Spiegelman, George B., Weeks, Gerald

“…Disruption of Dictyostelium rasC, encoding a Ras subfamily protein, generated cells incapable of aggregation. While rasC expression is enriched in a cell…”
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Money as Social Exergy by Spiegelman, George, Spiegelman, Eli, Spiegelman, Jonah

“…It has been proposed that open thermodynamic systems will act to dissipate available energy gradients by self-organizing into coherent structures that, with…”
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An activated Ras protein alters cell adhesion by dephosphorylating Dictyostelium DdCAD-1 by Secko, David M, Siu, Chi-Hung, Spiegelman, George B, Weeks, Gerald

“…1 Department of Microbiology and Immunology, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, British Columbia V6T…”
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Evidence for a role for the Dictyostelium Rap1 in cell viability and the response to osmotic stress by Kang, Rujun, Kae, Helmut, Ip, Hermia, Spiegelman, George B, Weeks, Gerald

“…The Dictyostelium genome contains a single rapA gene, which encodes a Rap1 monomeric G protein. As attempts at generating rapA-null Dictyostelium cells had…”
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Soj Antagonizes Spo0A Activation of Transcription in Bacillus subtilis by MCLEOD, Brett N, SPIEGELMAN, George B

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Dimer formation and transcription activation in the sporulation response regulator Spo0A by Lewis, Richard J, Scott, David J, Brannigan, James A, Ladds, Joanne C, Cervin, Marguerite A, Spiegelman, George B, Hoggett, James G, Barák, Imrich, Wilkinson, Anthony J

“…The response regulator Spo0A is the master control element in the initiation of sporulation in Bacillus subtilis. Like many other multi-domain response…”
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