Search Results - "Spieß, Birgit"

Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species by Dudakova, Anna, Spiess, Birgit, Tangwattanachuleeporn, Marut, Sasse, Christoph, Buchheidt, Dieter, Weig, Michael, Groß, Uwe, Bader, Oliver

“…The incidence of azole resistance in species has increased over the past years, most importantly for . This is partially attributable to the global spread of…”
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Diagnosis of invasive aspergillosis in hematological malignancy patients: Performance of cytokines, Asp LFD, and Aspergillus PCR in same day blood and bronchoalveolar lavage samples by Heldt, Sven, Prattes, Juergen, Eigl, Susanne, Spiess, Birgit, Flick, Holger, Rabensteiner, Jasmin, Johnson, Gemma, Prüller, Florian, Wölfler, Albert, Niedrist, Tobias, Boch, Tobias, Neumeister, Peter, Strohmaier, Heimo, Krause, Robert, Buchheidt, Dieter, Hoenigl, Martin

“…•Blood and BALF biomarkers for diagnosis of invasive aspergillosis were evaluated.•Biomarkers showed overall better performance in BALF compared to blood.•In…”
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Diagnostic performance of the molecular BCR-ABL1 monitoring system may impact on inclusion of CML patients in stopping trials by Spiess, Birgit, Rinaldetti, Sébastien, Naumann, Nicole, Galuschek, Norbert, Kossak-Roth, Ute, Wuchter, Patrick, Tarnopolscaia, Irina, Rose, Diana, Voskanyan, Astghik, Fabarius, Alice, Hofmann, Wolf-Karsten, Saußele, Susanne, Seifarth, Wolfgang

“…In chronic myeloid leukemia (CML), the duration of deep molecular response (MR) before treatment cessation (MR4 or deeper, corresponding to BCR-ABL1 ≤ 0.01% on…”
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Multicenter evaluation of a lateral-flow device test for diagnosing invasive pulmonary aspergillosis in ICU patients by Eigl, Susanne, Prattes, Juergen, Lackner, Michaela, Willinger, Birgit, Spiess, Birgit, Reinwald, Mark, Selitsch, Brigitte, Meilinger, Michael, Neumeister, Peter, Reischies, Frederike, Wölfler, Albert, Raggam, Reinhard B, Flick, Holger, Eschertzhuber, Stephan, Krause, Robert, Buchheidt, Dieter, Thornton, Christopher R, Lass-Flörl, Cornelia, Hoenigl, Martin

“…The incidence of invasive pulmonary aspergillosis (IPA) in intensive care unit (ICU) patients is increasing, and early diagnosis of the disease and treatment…”
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Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients by Spiess, Birgit, Kleiner, Helga, Flach, Johanna, Fabarius, Alice, Saussele, Susanne, Hofmann, Wolf-Karsten, Seifarth, Wolfgang

“…Separase, a cysteine endopeptidase, is a key player in mitotic sister chromatid separation, replication fork dynamics, and DNA repair. Aberrant expression…”
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Diagnostic performance of an Aspergillus-specific nested PCR assay in cerebrospinal fluid samples of immunocompromised patients for detection of central nervous system aspergillosis by Reinwald, Mark, Buchheidt, Dieter, Hummel, Margit, Duerken, Matthias, Bertz, Hartmut, Schwerdtfeger, Rainer, Reuter, Stefan, Kiehl, Michael G, Barreto-Miranda, Manuel, Hofmann, Wolf-Karsten, Spiess, Birgit

“…Central nervous system (CNS) invasive aspergillosis (IA) is a fatal complication in immunocompromised patients. Confirming the diagnosis is rarely accomplished…”
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The benefit of quality control charts (QCC) for routine quantitative BCR-ABL1 monitoring in chronic myeloid leukemia by Spiess, Birgit, Naumann, Nicole, Galuschek, Norbert, Rinaldetti, Sébastien, Kossak-Roth, Ute, Tarnopolscaia, Irina, Felde, Elena, Fabarius, Alice, Hofmann, Wolf-Karsten, Saußele, Susanne, Seifarth, Wolfgang

“…Quantitative real-time polymerase chain reaction (qRT-PCR) is state of the art in molecular monitoring of minimal residual disease in chronic myeloid leukemia…”
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Proteins Marking the Sequence of Genotoxic Signaling from Irradiated Mesenchymal Stromal Cells to CD34+ Cells by Kohl, Vanessa, Drews, Oliver, Costina, Victor, Bierbaum, Miriam, Jawhar, Ahmed, Roehl, Henning, Weiss, Christel, Brendel, Susanne, Kleiner, Helga, Flach, Johanna, Spiess, Birgit, Seifarth, Wolfgang, Nowak, Daniel, Hofmann, Wolf-Karsten, Fabarius, Alice, Popp, Henning D.

“…Non-targeted effects (NTE) of ionizing radiation may initiate myeloid neoplasms (MN). Here, protein mediators (I) in irradiated human mesenchymal stromal cells…”
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Development of Novel PCR Assays To Detect Azole Resistance-Mediating Mutations of the Aspergillus fumigatus cyp51A Gene in Primary Clinical Samples from Neutropenic Patients by SPIESS, Birgit, SEIFARTH, Wolfgang, MERKER, Natalia, HOWARD, Susan J, REINWALD, Mark, DIETZ, Anne, HOFMANN, Wolf-Karsten, BUCHHEIDT, Dieter

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Incidence of Cyp51 A key mutations in Aspergillus fumigatus-a study on primary clinical samples of immunocompromised patients in the period of 1995-2013 by Spiess, Birgit, Postina, Patricia, Reinwald, Mark, Cornely, Oliver A, Hamprecht, Axel, Hoenigl, Martin, Lass-Flörl, Cornelia, Rath, Peter-Michael, Steinmann, Jörg, Miethke, Thomas, Lauten, Melchior, Will, Silke, Merker, Natalia, Hofmann, Wolf-Karsten, Buchheidt, Dieter

“…As the incidence of azole resistance in Aspergillus fumigatus is rising and the diagnosis of invasive aspergillosis (IA) in immunocompromised patients is…”
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DNA Microarray-Based Detection and Identification of Fungal Pathogens in Clinical Samples from Neutropenic Patients by SPIESS, Birgit, SEIFARTH, Wolfgang, HUMMEL, Margit, FRANK, Oliver, FABARIUS, Alice, CHUN ZHENG, MÖRZ, Handan, HEHLMANN, Rüdiger, BUCHHEIDT, Dieter

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Comparison of Two Molecular Assays for Detection and Characterization of Aspergillus fumigatus Triazole Resistance and Cyp51A Mutations in Clinical Isolates and Primary Clinical Samples of Immunocompromised Patients by Postina, Patricia, Skladny, Julian, Boch, Tobias, Cornely, Oliver A, Hamprecht, Axel, Rath, Peter-Michael, Steinmann, Jörg, Bader, Oliver, Miethke, Thomas, Dietz, Anne, Merker, Natalia, Hofmann, Wolf-Karsten, Buchheidt, Dieter, Spiess, Birgit

“…In hematological patients, the incidence of invasive aspergillosis (IA) caused by azole resistant (ARAf) is rising. As the diagnosis of IA is rarely based on…”
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Comprehensive Analysis of Human Endogenous Retrovirus Transcriptional Activity in Human Tissues with a Retrovirus-Specific Microarray by SEIFARTH, Wolfgang, FRANK, Oliver, ZEILFELDER, Udo, SPIESS, Birgit, GREENWOOD, Alex D, HEHLMANN, Rüdiger, LEIB-MÖSCH, Christine

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A new aberrantly spliced BCR‐ABL1 transcript variant (e13a1) identified in routine monitoring using different quantitative reverse transcription polymerase chain reaction techniques in a patient with chronic myeloid leukemia by Naumann, Nicole, Bross‐Bach, Ulrike, Seifarth, Wolfgang, Fabarius, Alice, Hofmann, Wolf‐Karsten, Saußele, Susanne, Spiess, Birgit

“…Quantitative reverse transcription polymerase chain reaction (qRT‐PCR) of BCR‐ABL1 transcript level is an essential part of routine disease monitoring in…”
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Effect of ABCG2, OCT1, and ABCB1 (MDR1) Gene Expression on Treatment-Free Remission in a EURO-SKI Subtrial by Rinaldetti, Sébastien, Pfirrmann, Markus, Manz, Kirsi, Guilhot, Joelle, Dietz, Christian, Panagiotidis, Panayiotidis, Spiess, Birgit, Seifarth, Wolfgang, Fabarius, Alice, Müller, Martin, Pagoni, Maria, Dimou, Maria, Dengler, Jolanta, Waller, Cornelius F., Brümmendorf, Tim H., Herbst, Regina, Burchert, Andreas, Janβen, Carsten, Goebeler, Maria Elisabeth, Jost, Philipp J., Hanzel, Stefan, Schafhausen, Philippe, Prange-Krex, Gabriele, Illmer, Thomas, Janzen, Viktor, Klausmann, Martine, Eckert, Robert, Büschel, Gerd, Kiani, Alexander, Hofmann, Wolf-Karsten, Mahon, François-Xavier, Saussele, Susanne

“…Within the EURO-SKI trial, 132 chronic phase CML patients discontinued imatinib treatment. RNA was isolated from peripheral blood in order to analyze the…”
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Development of a LightCycler PCR Assay for Detection and Quantification of Aspergillus fumigatus DNA in Clinical Samples from Neutropenic Patients by SPIESS, Birgit, BUCHHEIDT, Dieter, BAUST, Corinna, SKLADNY, Heyko, SEIFARTH, Wolfgang, ZEILFELDER, Udo, LEIB-MÖSCH, Christine, MÖRZ, Handan, HEHLMANN, Rüdiger

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Performance of the Bronchoalveolar Lavage Fluid Aspergillus Galactomannan Lateral Flow Assay With Cube Reader for Diagnosis of Invasive Pulmonary Aspergillosis: A Multicenter Cohort Study by Jenks, Jeffrey D, Prattes, Juergen, Frank, Johanna, Spiess, Birgit, Mehta, Sanjay R, Boch, Tobias, Buchheidt, Dieter, Hoenigl, Martin

“…Abstract Background The Aspergillus Galactomannan Lateral Flow Assay (LFA) is a rapid test for the diagnosis of invasive aspergillosis (IA) that has been…”
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Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology by Hoenigl, Martin, Salmanton-García, Jon, Walsh, Thomas J, Nucci, Marcio, Neoh, Chin Fen, Jenks, Jeffrey D, Lackner, Michaela, Sprute, Rosanne, Al-Hatmi, Abdullah M S, Bassetti, Matteo, Carlesse, Fabianne, Freiberger, Tomas, Koehler, Philipp, Lehrnbecher, Thomas, Kumar, Anil, Prattes, Juergen, Richardson, Malcolm, Revankar, Sanjay, Slavin, Monica A, Stemler, Jannik, Spiess, Birgit, Taj-Aldeen, Saad J, Warris, Adilia, Woo, Patrick C Y, Young, Jo-Anne H, Albus, Kerstin, Arenz, Dorothee, Arsic-Arsenijevic, Valentina, Bouchara, Jean-Philippe, Chinniah, Terrence Rohan, Chowdhary, Anuradha, de Hoog, G Sybren, Dimopoulos, George, Duarte, Rafael F, Hamal, Petr, Meis, Jacques F, Mfinanga, Sayoki, Queiroz-Telles, Flavio, Patterson, Thomas F, Rahav, Galia, Rogers, Thomas R, Rotstein, Coleman, Wahyuningsih, Retno, Seidel, Danila, Cornely, Oliver A

“…With increasing numbers of patients needing intensive care or who are immunosuppressed, infections caused by moulds other than Aspergillus spp or Mucorales are…”
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Galactomannan testing and Aspergillus PCR in same-day bronchoalveolar lavage and blood samples for diagnosis of invasive aspergillosis by Eigl, Susanne, Hoenigl, Martin, Spiess, Birgit, Heldt, Sven, Prattes, Juergen, Neumeister, Peter, Wolfler, Albert, Rabensteiner, Jasmin, Prueller, Florian, Krause, Robert, Reinwald, Mark, Flick, Holger, Buchheidt, Dieter, Boch, Tobias

“…Abstract In recent years galactomannan antigen testing (GM) and also Aspergillus PCR have become increasingly important for diagnosis of invasive aspergillosis…”
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The evolving landscape of new diagnostic tests for invasive aspergillosis in hematology patients: strengths and weaknesses by Buchheidt, Dieter, Reinwald, Mark, Hoenigl, Martin, Hofmann, Wolf-Karsten, Spiess, Birgit, Boch, Tobias

“…The diagnosis of invasive aspergillosis in hematologic patients is a complex composite of clinical preconditions and features, imaging findings, biomarker…”
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