Search Results - "Spichty, Martin"

A single-chain and fast-responding light-inducible Cre recombinase as a novel optogenetic switch by Duplus-Bottin, Hélène, Spichty, Martin, Triqueneaux, Gérard, Place, Christophe, Mangeot, Philippe Emmanuel, Ohlmann, Théophile, Vittoz, Franck, Yvert, Gaël

“…Optogenetics enables genome manipulations with high spatiotemporal resolution, opening exciting possibilities for fundamental and applied biological research…”
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Physical and functional interaction between SET1/COMPASS complex component CFP-1 and a Sin3S HDAC complex in C. elegans by Beurton, Flore, Stempor, Przemyslaw, Caron, Matthieu, Appert, Alex, Dong, Yan, Chen, Ron A-j, Cluet, David, Couté, Yohann, Herbette, Marion, Huang, Ni, Polveche, Hélène, Spichty, Martin, Bedet, Cécile, Ahringer, Julie, Palladino, Francesca

“…Abstract The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3…”
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Assigning function to natural allelic variation via dynamic modeling of gene network induction by Richard, Magali, Chuffart, Florent, Duplus‐Bottin, Hélène, Pouyet, Fanny, Spichty, Martin, Fulcrand, Etienne, Entrevan, Marianne, Barthelaix, Audrey, Springer, Michael, Jost, Daniel, Yvert, Gaël

“…More and more natural DNA variants are being linked to physiological traits. Yet, understanding what differences they make on molecular regulations remains…”
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Long Distance Charge Transport through DNA: Quantification and Extension of the Hopping Model by Giese, Bernd, Spichty, Martin

“…Long distance charge transport through DNA occurs by a hopping mechanism. If the positive charge is injected into a guanine base, all guanines act as charge…”
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Automated high-throughput quantification of mitotic spindle positioning from DIC movies of Caenorhabditis embryos by Cluet, David, Stébé, Pierre-Nicolas, Riche, Soizic, Spichty, Martin, Delattre, Marie

“…The mitotic spindle is a microtubule-based structure that elongates to accurately segregate chromosomes during anaphase. Its position within the cell also…”
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Electron Transfer through DNA in the Course of Radical-Induced Strand Cleavage by Meggers, Eric, Kusch, Dirk, Spichty, Martin, Wille, Uta, Giese, Bernd

“…No benefit from base stacking is observed for rates of electron transfer in DNA. This conclusion was drawn from experiments with a new DNA assay in which a…”
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Mechanistic Course of the Asymmetric Methoxyselenenylation Reaction by Wirth, Thomas, Fragale, Gianfranco, Spichty, Martin

“…In alkoxyselenenylation reactions of alkenes intermediate seleniranium ions 1 are formed. In competition experiments it was shown that the formation of these…”
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Role of Conformational Heterogeneity in Domain Swapping and Adapter Function of the Cks Proteins by Seeliger, Markus A., Spichty, Martin, Kelly, Sadie E., Bycroft, Mark, Freund, Stefan M.V., Karplus, Martin, Itzhaki, Laura S.

“…Cks proteins are adapter molecules that coordinate the assembly of multiprotein complexes. They share the ability to domain swap by exchanging a β-strand, β4…”
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Deconstructing Best-in-Class Neoglycoclusters as a Tool for Dissecting Key Multivalent Processes in Glycosidase Inhibition by Liang, Yan, Schettini, Rosaria, Kern, Nicolas, Manciocchi, Luca, Izzo, Irene, Spichty, Martin, Bodlenner, Anne, Compain, Philippe

“…Multivalency represents an appealing option to modulate selectivity in enzyme inhibition and transform moderate glycosidase inhibitors into highly potent ones…”
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Thermodynamics and kinetics of large-time-step molecular dynamics by Rao, Francesco, Spichty, Martin

“…Molecular dynamics (MD) simulations provide essential information about the thermodynamics and kinetics of proteins. Technological advances in both hardware…”
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Structure-activity relationship and molecular modelling studies of quinazolinedione derivatives MMV665916 as potential antimalarial agent by Mourot, Laura, Schmitt, Marjorie, Mouray, Elisabeth, Spichty, Martin, Florent, Isabelle, Albrecht, Sébastien

“…[Display omitted] •A new series of 27 quinazolinedione derivatives of MMV665916 were designed and readily synthesized.•All compounds displayed antiplasmodial…”
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Conformational Dynamics in a Methacrylate-Derived Radical: A Computational and EPR Study by Spichty, Martin, Giese, Bernd, Matsumoto, Akikazu, Fischer, Hanns, Gescheidt, Georg

“…Dynamic phenomena are established for the [D 3]methyl (2SR,3RS)-2-methyl-4,4,4-trichlorobutanoate-2-yl radical (1). This is revealed by EPR spectroscopy and…”
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A conceptually improved TD-DFT approach for predicting the maximum absorption wavelength of cyanine dyes by Meguellati, Kamel, Ladame, Sylvain, Spichty, Martin

“…Cyanine dyes have found valuable applications in modern bioresearch because of their biocompatibility, high molar absorptivity and moderate fluorescence…”
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Titration of Apparent In‐Cellula Affinities of Protein‐Protein Interactions by Cluet, David, Vergier, Blandine, Levy, Nicolas‐Pierre, Dehau, Lucie, Thurman, Alexandre, Amri, Ikram, Spichty, Martin

“…A genetic assay permits simultaneous quantification of two interacting proteins and their bound fraction at the single‐cell level using flow cytometry…”
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Topological Dynamics of a Radical Ion Pair: Experimental and Computational Assessment at the Relevant Nanosecond Timescale by Quast, Helmut, Gescheidt, Georg, Spichty, Martin

“…Chemical processes mostly happen in fluid environments where reaction partners encounter via diffusion. The bimolecular encounters take place at a nanosecond…”
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A Differential Fluctuation Theorem by Maragakis, Paul, Spichty, Martin, Karplus, Martin

“…We derive a nonequilibrium thermodynamics identity (the “differential fluctuation theorem”) that connects forward and reverse joint probabilities of…”
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A Quantitative Tri-fluorescent Yeast Two-hybrid System: From Flow Cytometry to In cellula Affinities by Cluet, David, Amri, Ikram, Vergier, Blandine, Léault, Jérémie, Audibert, Astrid, Grosjean, Clémence, Calabrési, Dylan, Spichty, Martin

“…We present a novel quantitative yeast two-hybrid (qY2H) system based on fluorescent fusion proteins. It permits simultaneous quantification of Bait, Prey and…”
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Eicosapentaenoic acid modulates the synergistic action of CREB1 and ID/E2A family members in the rat pup brain and mouse embryonic stem cells by Rossi, Maurizio, Spichty, Martin, Attorri, Lucilla, Distante, Chiara, Nervi, Clara, Salvati, Serafina, Vitelli, Luigi

“…The aim of this study was to investigate the molecular mechanism by which eicosapentaenoic acid (EPA) may exert neuroprotective effects through an “EPA-cyclic…”
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Methionine-Based Radicals: Time Scales and Species by Neshchadin, Dmytro, Kelterer, Anne-Marie, Houée-Levin, Chantal, Stadler, Eduard, Spichty, Martin, Gescheidt, Georg

“…l -Methionine is an amino acid, which provides anti-oxidative properties. We report on radicals and radical cations being likely (short-lived) intermediates…”
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Conformational Free-Energy Difference of a Miniprotein from Nonequilibrium Simulations by Spichty, Martin, Cecchini, Marco, Karplus, Martin

“…Conformational free-energy differences are essential thermodynamic quantities for understanding the function of many biomolecules. They are accessible from…”
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