Search Results - "Sphyris, N"

GD3 synthase regulates epithelial–mesenchymal transition and metastasis in breast cancer by Sarkar, T R, Battula, V L, Werden, S J, Vijay, G V, Ramirez-Peña, E Q, Taube, J H, Chang, J T, Miura, N, Porter, W, Sphyris, N, Andreeff, M, Mani, S A

“…The epithelial–mesenchymal transition (EMT) bestows cancer cells with increased stem cell properties and metastatic potential. To date, multiple extracellular…”
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Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties by Paranjape, A N, Soundararajan, R, Werden, S J, Joseph, R, Taube, J H, Liu, H, Rodriguez-Canales, J, Sphyris, N, Wistuba, I, Miura, N, Dhillon, J, Mahajan, N, Mahajan, K, Chang, J T, Ittmann, M, Maity, S N, Logothetis, C, Tang, D G, Mani, S A

“…Advanced prostate adenocarcinomas enriched in stem-cell features, as well as variant androgen receptor (AR)-negative neuroendocrine (NE)/small-cell prostate…”
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Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth by Werden, S J, Sphyris, N, Sarkar, T R, Paranjape, A N, LaBaff, A M, Taube, J H, Hollier, B G, Ramirez-Peña, E Q, Soundararajan, R, den Hollander, P, Powell, E, Echeverria, G V, Miura, N, Chang, J T, Piwnica-Worms, H, Rosen, J M, Mani, S A

“…Metastatic competence is contingent upon the aberrant activation of a latent embryonic program, known as the epithelial–mesenchymal transition (EMT), which…”
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p73α is a candidate effector in the p53 independent apoptosis pathway of cisplatin damaged primary murine colonocytes by Oniscu, A, Sphyris, N, Morris, R G, Bader, S, Harrison, D J

“…Aims: Colonocytes were derived from wild-type (wt) and p53 deficient mice to investigate p53 dependent and independent death pathways after cisplatin…”
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Mutational analysis of the Ricinus lectin B-chains: galactose-binding ability of the 2 gamma subdomain of Ricinus communis agglutinin B-chain by Sphyris, N. (University of Warwick, Coventry, UK.), Lord, J.M, Wales, R, Roberts, L.M

“…Ricin B-chain (RTB) is a galactose-specific lectin that folds into two globular domains, each of which binds a single galactoside. The two binding sites are…”
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NOTUM from Apc-mutant cells biases clonal competition to initiate cancer by Flanagan, Dustin J., Pentinmikko, Nalle, Luopajärvi, Kalle, Willis, Nicky J., Gilroy, Kathryn, Raven, Alexander P., Mcgarry, Lynn, Englund, Johanna I., Webb, Anna T., Scharaw, Sandra, Nasreddin, Nadia, Hodder, Michael C., Ridgway, Rachel A., Minnee, Emma, Sphyris, Nathalie, Gilchrist, Ella, Najumudeen, Arafath K., Romagnolo, Beatrice, Perret, Christine, Williams, Ann C., Clevers, Hans, Nummela, Pirjo, Lähde, Marianne, Alitalo, Kari, Hietakangas, Ville, Hedley, Ann, Clark, William, Nixon, Colin, Kirschner, Kristina, Jones, E. Yvonne, Ristimäki, Ari, Leedham, Simon J., Fish, Paul V., Vincent, Jean-Paul, Katajisto, Pekka, Sansom, Owen J.

“…The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice…”
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pIgR: Frenemy of Inflammation, EMT, and HCC Progression by Sphyris, Nathalie, Mani, Sendurai A.

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p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells by SPHYRIS, Nathalie, HARRISON, David J

“…In a primary culture model for pancreatic acinar-ductal transdifferentiation, cells exhibited increased proliferation, changes in nuclearity and polyploidy. We…”
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Improved retention of zymogen granules in cultured murine pancreatic acinar cells and induction of acinar-ductal transdifferentiation in vitro by Sphyris, Nathalie, Logsdon, Craig D, Harrison, David J

“…To establish a primary culture model for murine pancreatic acinar cells and to investigate the effects of different culture conditions on the phenotype and…”
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p73[alpha] is a candidate effector in the p53 independent apoptosis pathway of cisplatin damaged primary murine colonocytes by Oniscu, A, Sphyris, N, Morris, R G, Bader, S, Harrison, D J

“…Aims: Colonocytes were derived from wild-type (wt) and p53 deficient mice to investigate p53 dependent and independent death pathways after cisplatin…”
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p73alpha is a candidate effector in the p53 independent apoptosis pathway of cisplatin damaged primary murine colonocytes by Oniscu, A, Sphyris, N, Morris, R G, Bader, S, Harrison, D J

“…Colonocytes were derived from wild-type (wt) and p53 deficient mice to investigate p53 dependent and independent death pathways after cisplatin treatment, and…”
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Apoptosis in vivo and in vitro: conflict or complementarity? by Clarke, Alan R., Sphyris, Nathalie, Harrison, David J.

“…Apoptosis is a genetically encoded series of events that culminates in cellular suicide. It is implicated in a wide variety of biological processes, including…”
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Glutathione and p53 independently mediate responses against oxidative stress in ES cells by Coe, Jonathan P, Rahman, Irfan, Sphyris, Nathalie, Clarke, Alan R, Harrison, David J

“…We have investigated the roles of the antioxidant glutathione and p53 in the response of embryonic stem (ES) cells to oxidative stress. ES cells express γGCS,…”
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