Search Results - "Speranza, Maria C"

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma by Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

“…Dexamethasone, a uniquely potent corticosteroid, is frequently administered to patients with brain tumors to decrease tumor-associated edema, but limited data…”
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Antigen presentation deficiency, mesenchymal differentiation, and resistance to immunotherapy in the murine syngeneic CT2A tumor model by Iorgulescu, J Bryan, Ruthen, Neil, Ahn, Ryuhjin, Panagioti, Eleni, Gokhale, Prafulla C, Neagu, Martha, Speranza, Maria C, Eschle, Benjamin K, Soroko, Kara M, Piranlioglu, Raziye, Datta, Meenal, Krishnan, Shanmugarajan, Yates, Kathleen B, Baker, Gregory J, Jain, Rakesh K, Suvà, Mario L, Neuberg, Donna, White, Forest M, Chiocca, E Antonio, Freeman, Gordon J, Sharpe, Arlene H, Wu, Catherine J, Reardon, David A

“…The GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct…”
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Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy by Passaro, Carmela, Alayo, Quazim, De Laura, Isabella, McNulty, John, Grauwet, Korneel, Ito, Hirotaka, Bhaskaran, Vivek, Mineo, Marco, Lawler, Sean E, Shah, Khalid, Speranza, Maria C, Goins, William, McLaughlin, Eric, Fernandez, Soledad, Reardon, David A, Freeman, Gordon J, Chiocca, E Antonio, Nakashima, Hiroshi

“…Glioblastoma (GBM) is resistant to standard of care. Immune checkpoints inhibitors (such as anti-PD-1 mAbs) efficiently restore antitumor T-cell activity. We…”
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Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles by Ricklefs, Franz L, Alayo, Quazim, Krenzlin, Harald, Mahmoud, Ahmad B, Speranza, Maria C, Nakashima, Hiroshi, Hayes, Josie L, Lee, Kyungheon, Balaj, Leonora, Passaro, Carmela, Rooj, Arun K, Krasemann, Susanne, Carter, Bob S, Chen, Clark C, Steed, Tyler, Treiber, Jeffrey, Rodig, Scott, Yang, Katherine, Nakano, Ichiro, Lee, Hakho, Weissleder, Ralph, Breakefield, Xandra O, Godlewski, Jakub, Westphal, Manfred, Lamszus, Katrin, Freeman, Gordon J, Bronisz, Agnieszka, Lawler, Sean E, Chiocca, E Antonio

“…Binding of programmed death ligand-1 (PD-L1) to programmed cell death protein-1 (PD1) leads to cancer immune evasion via inhibition of T cell function. One of…”
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Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma mouse models by Datta, Meenal, Chatterjee, Sampurna, Perez, Elizabeth M, Gritsch, Simon, Roberge, Sylvie, Duquette, Mark, Chen, Ivy X, Naxerova, Kamila, Kumar, Ashwin S, Ghosh, Mitrajit, Emblem, Kyrre E, Ng, Mei R, Ho, William W, Kumar, Pragya, Krishnan, Shanmugarajan, Dong, Xinyue, Speranza, Maria C, Neagu, Martha R, Iorgulescu, J Bryan, Huang, Raymond Y, Youssef, Gilbert, Reardon, David A, Sharpe, Arlene H, Freeman, Gordon J, Suvà, Mario L, Xu, Lei, Jain, Rakesh K

“…Immune checkpoint blockers (ICBs) have failed in all phase III glioblastoma trials. Here, we found that ICBs induce cerebral edema in some patients and mice…”
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Correction: Arming an Oncolytic Herpes Simplex Virus Type 1 with a Single-chain Fragment Variable Antibody against PD-1 for Experimental Glioblastoma Therapy by Passaro, Carmela, Alayo, Quazim, DeLaura, Isabel, McNulty, John, Grauwet, Korneel, Ito, Hirotaka, Bhaskaran, Vivek, Mineo, Marco, Lawler, Sean E, Shah, Khalid, Speranza, Maria C, Goins, William, McLaughlin, Eric, Fernandez, Soledad, Reardon, David A, Freeman, Gordon J, Chiocca, E Antonio, Nakashima, Hiroshi

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TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy by Liu, Heng-Jia, Lizotte, Patrick H, Du, Heng, Speranza, Maria C, Lam, Hilaire C, Vaughan, Spencer, Alesi, Nicola, Wong, Kwok-Kin, Freeman, Gordon J, Sharpe, Arlene H, Henske, Elizabeth P

“…Tuberous sclerosis complex (TSC) is an incurable multisystem disease characterized by mTORC1-hyperactive tumors. TSC1/2 mutations also occur in other…”
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Abstract 3242: Triple checkpoint blockade targeting PD-1, TIM-3, and LAG-3 reinvigorates ovarian cancer-infiltrating T cells by increasing T cell polyfunctionality and effector function by Kaufmann, Johanna K., Flynn, Brianna, Morse, Kevin, Speranza, Maria C., Zhou, Jing, Ramaswamy, Sridhar, Mackay, Sean, Coleman, Kevin G.

“…Abstract Co-expression of immune checkpoint receptors (ICRs) PD-1, TIM-3, and LAG-3 characterizes chronically activated and exhausted tumor-infiltrating T…”
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Abstract 417: Defining molecular mechanisms of resistance to glioblastoma immunity using a novel CRISPR/Cas9 in vivo loss-of-function screening platform by Neagu, Martha R., Manguso, Robert T., Pope, Hans, Speranza, Maria C., Freeman, Gordon J., Doench, John, Sharpe, Arlene H., Haining, William Nicholas

“…Abstract OVERVIEW: Despite the impact of cancer immunotherapy, expanding its clinical utility requires a rational method for identifying combination therapies…”
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AI-27BKM-120: AN ANTI-INVASIVE CANDIDATE FOR THE TREATMENT OF GLIOBLASTOMA by Speranza, Maria C., Nowicki, Michal O., Antonio Chiocca, E., Lawler, Sean E.

“…BKM-120 is a selective pan-class I phosphatidyl-inositol-3 kinase (PI3K) inhibitor. BKM-120 can penetrate the blood-brain barrier and it is currently in…”
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AI-27 BKM-120: AN ANTI-INVASIVE CANDIDATE FOR THE TREATMENT OF GLIOBLASTOMA by Speranza, M. C., Nowicki, M. O., Antonio Chiocca, E., Lawler, S. E.

“…BKM-120 is a selective pan-class I phosphatidyl-inositol-3 kinase (PI3K) inhibitor. BKM-120 can penetrate the blood-brain barrier and it is currently in…”
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