Search Results - "Speranta Avram"

Chondroitin Sulfate Proteoglycans : Structure-Function Relationship with Implication in Neural Development and Brain Disorders by Avram, Speranta, Shaposhnikov, Sergey, Buiu, Catalin, Mernea, Maria

“…Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix components that contain two structural parts with distinct functions: a protein core and…”
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Copper(II) species with 1‐(o‐tolyl)biguanide: Structural characterization, ROS scavenging, antibacterial activity, biocompatibility and in silico studies by Maxim, Catalin, Badea, Mihaela, Rostas, Arpad Mihai, Chifiriuc, Mariana Carmen, Pircalabioru, Gratiela Gradisteanu, Avram, Speranța, Olar, Rodica

“…The species cis‐[Cu(tbg)2](ClO4)2 (CuTP) (tbg: 1‐(o‐tolyl)biguanide) was designed as a novel antimicrobial and biocompatible agent. The single‐crystal X‐ray…”
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The applications of machine learning in HIV neutralizing antibodies research—A systematic review by Dănăilă, Vlad-Rareş, Avram, Speranţa, Buiu, Cătălin

“…Machine learning algorithms play an essential role in bioinformatics and allow exploring the vast and noisy biological data in unrivaled ways. This paper is a…”
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In Silico and In Vitro Experimental Studies of New Dibenz[ b , e ]oxepin-11(6 H )one O-(arylcarbamoyl)-oximes Designed as Potential Antimicrobial Agents by Vlad, Ilinca Margareta, Nuta, Diana Camelia, Chirita, Cornel, Caproiu, Miron Teodor, Draghici, Constantin, Dumitrascu, Florea, Bleotu, Coralia, Avram, Speranța, Udrea, Ana Maria, Missir, Alexandru Vasile, Marutescu, Luminita Gabriela, Limban, Carmen

“…In a drug-repurposing-driven approach for speeding up the development of novel antimicrobial agents, this paper presents for the first time in the scientific…”
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Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9H-carbazol Derivatives and 1,3,4-Oxadiazole Scaffolds by Bordei Telehoiu, Alexandra T., Nuță, Diana C., Căproiu, Miron T., Dumitrascu, Florea, Zarafu, Irina, Ioniță, Petre, Bădiceanu, Carmellina D., Avram, Speranța, Chifiriuc, Mariana C., Bleotu, Coralia, Limban, Carmen

“…In this paper, we aimed to exploit and combine in the same molecule the carbazole and the 1,3,4-oxadiazole pharmacophores, to obtain novel carprofen…”
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Interaction of anti-inflammatory drug nimesulide with ionic and non-ionic surfactant micelles: Insights from spectral and bioinformatics approach by Enache, Mirela, Andriesei, Bianca Mihaela, Oancea, Alexandra, Udrea, Ana-Maria, Raducan, Adina, Oancea, Petruta, Avram, Speranța

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Bioinformatics Tools for the Analysis of Active Compounds Identified in Ranunculaceae Species by Mareş, Cătălina, Udrea, Ana-Maria, Şuţan, Nicoleta Anca, Avram, Speranţa

“…The chemical compounds from extracts of three Ranunculaceae species, Rchb., L. and Waldst. & Kit. ex Willd., respectively, were isolated using the HPLC…”
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Photosensitizers-Loaded Nanocarriers for Enhancement of Photodynamic Therapy in Melanoma Treatment by Udrea, Ana Maria, Smarandache, Adriana, Dinache, Andra, Mares, Catalina, Nistorescu, Simona, Avram, Speranta, Staicu, Angela

“…Malignant melanoma poses a significant global health burden. It is the most aggressive and lethal form of skin cancer, attributed to various risk factors such…”
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Potential Therapeutic Approaches to Alzheimer's Disease By Bioinformatics, Cheminformatics And Predicted Adme-Tox Tools by Avram, Speranta, Mernea, Maria, Limban, Carmen, Borcan, Florin, Chifiriuc, Carmen

“…Background: Alzheimer’s disease (AD) is considered a severe, irreversible and progressive neurodegenerative disorder. Currently, the pharmacological management…”
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Design of a Synthetic Long Peptide Vaccine Targeting HPV-16 and -18 Using Immunoinformatic Methods by Tîrziu, Alexandru, Avram, Speranța, Madă, Leonard, Crișan-Vida, Mihaela, Popovici, Casiana, Popovici, Dan, Faur, Cosmin, Duda-Seiman, Corina, Păunescu, Virgil, Vernic, Corina

“…Human papillomavirus types 16 and 18 cause the majority of cervical cancers worldwide. Despite the availability of three prophylactic vaccines based on…”
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Natural Compounds Therapeutic Features in Brain Disorders by Experimental, Bioinformatics and Cheminformatics Methods by Avram, Speranta, Puia, Alin, Udrea, Ana Maria, Mihailescu, Dan, Mernea, Maria, Dinischiotu, Anca, Oancea, Florin, Stiens, Johan

“…Synthetic compounds with pharmaceutical applications in brain disorders are daily designed and synthesized, with well first effects but also seldom severe side…”
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Target Prediction of 5,10,15,20-Tetrakis(4'-Sulfonatophenyl)-Porphyrin Using Molecular Docking by Udrea, Ana-Maria, Dinache, Andra, Staicu, Angela, Avram, Speranta

“…Photodynamic therapy has the potential to be a new and effective cancer treatment. Even if in vitro and in vivo research show promise, the molecular mechanism…”
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COMPUTATIONAL APPROACHES OF NEW PERSPECTIVES IN THE TREATMENT OF DEPRESSION DURING PREGNANCY by UDREA, ANA-MARIA

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Synthesis and Bioinformatic Characterization of New Schiff Bases with Possible Applicability in Brain Disorders by Avram, Speranta, Udrea, Ana Maria, Nuta, Diana Camelia, Limban, Carmen, Balea, Adrian Cosmin, Caproiu, Miron Teodor, Dumitrascu, Florea, Buiu, Cătălin, Bordei, Alexandra Teodora

“…(1) Background: The research aims to find new treatments for neurodegenerative diseases, in particular, Alzheimer’s disease. (2) Methods: This article presents…”
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In Silico and Experimental Investigation of the Biological Potential of Some Recently Developed Carprofen Derivatives by Dumitrascu, Florea, Udrea, Ana-Maria, Caira, Mino R, Nuta, Diana Camelia, Limban, Carmen, Chifiriuc, Mariana Carmen, Popa, Marcela, Bleotu, Coralia, Hanganu, Anamaria, Dumitrescu, Denisa, Avram, Speranta

“…The efficient regioselective bromination and iodination of the nonsteroidal anti-inflammatory drug (NSAID) carprofen were achieved by using bromine and iodine…”
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Advanced Bioinformatics Tools in the Pharmacokinetic Profiles of Natural and Synthetic Compounds with Anti-Diabetic Activity by Udrea, Ana Maria, Gradisteanu Pircalabioru, Gratiela, Boboc, Anca Andreea, Mares, Catalina, Dinache, Andra, Mernea, Maria, Avram, Speranta

“…Diabetes represents a major health problem, involving a severe imbalance of blood sugar levels, which can disturb the nerves, eyes, kidneys, and other organs…”
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Biogenic synthesis of noble metal nanoparticles using Melissa officinalis L. and Salvia officinalis L. extracts and evaluation of their biosafety potential by Manolescu, Denisa, Uță, Georgiana, Șuțan, Anca, Ducu, Cătălin, Din, Alin, Moga, Sorin, Negrea, Denis, Biță, Andrei, Bejenaru, Ludovic, Bejenaru, Cornelia, Avram, Speranța

“…In this study we targeted the noble metal nanoparticles (MNPs) biogenic synthesis capacity of two medicinal species with therapeutic potential, namely Melissa…”
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Learning the Relationship between the Primary Structure of HIV Envelope Glycoproteins and Neutralization Activity of Particular Antibodies by Using Artificial Neural Networks by Buiu, Cătălin, Putz, Mihai V, Avram, Speranta

“…The dependency between the primary structure of HIV envelope glycoproteins (ENV) and the neutralization data for given antibodies is very complicated and…”
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Current Perspectives on Biological Screening of Newly Synthetised Sulfanilamide Schiff Bases as Promising Antibacterial and Antibiofilm Agents by Coanda, Maria, Limban, Carmen, Draghici, Constantin, Ciobanu, Anne-Marie, Grigore, Georgiana Alexandra, Popa, Marcela, Stan, Miruna, Larion, Cristina, Avram, Speranta, Mares, Catalina, Ciornei, Mariana-Catalina, Dabu, Aura, Hudita, Ariana, Galateanu, Bianca, Pintilie, Lucia, Nuta, Diana Camelia

“…Growing resistance to antimicrobials, combined with pathogens that form biofilms, presents significant challenges in healthcare. Modifying current…”
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3D-ALMOND-QSAR Models to Predict the Antidepressant Effect of Some Natural Compounds by Avram, Speranta, Stan, Miruna Silvia, Udrea, Ana Maria, Buiu, Cătălin, Boboc, Anca Andreea, Mernea, Maria

“…The current treatment of depression involves antidepressant synthetic drugs that have a variety of side effects. In searching for alternatives, natural…”
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