Search Results - "Spencer, Sandra E."

Proteomic analysis of archival breast cancer clinical specimens identifies biological subtypes with distinct survival outcomes by Asleh, Karama, Negri, Gian Luca, Spencer Miko, Sandra E., Colborne, Shane, Hughes, Christopher S., Wang, Xiu Q., Gao, Dongxia, Gilks, C. Blake, Chia, Stephen K. L., Nielsen, Torsten O., Morin, Gregg B.

“…Despite advances in genomic classification of breast cancer, current clinical tests and treatment decisions are commonly based on protein level information…”
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Loss of m1acp3Ψ Ribosomal RNA Modification Is a Major Feature of Cancer by Babaian, Artem, Rothe, Katharina, Girodat, Dylan, Minia, Igor, Djondovic, Sara, Milek, Miha, Spencer Miko, Sandra E., Wieden, Hans-Joachim, Landthaler, Markus, Morin, Gregg B., Mager, Dixie L.

“…The ribosome is an RNA-protein complex that is essential for translation in all domains of life. The structural and catalytic core of the ribosome is its…”
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Characterizing the secretome of EGFR mutant lung adenocarcinoma by Luu, Jennifer K, Johnson, Fraser D, Jajarmi, Jana, Sihota, Tianna, Shi, Rocky, Lu, Daniel, Farnsworth, Dylan, Spencer, Sandra E, Negri, Gian Luca, Morin, Gregg B, Lockwood, William W

“…Lung cancer is the leading cause of cancer related death worldwide, mainly due to the late stage of disease at the time of diagnosis. Non-invasive biomarkers…”
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Dependence of human cell survival and proliferation on the CASP3 prodomain by Eskandari, Ebrahim, Negri, Gian Luca, Tan, Susanna, MacAldaz, Margarita E., Ding, Shengsen, Long, Justin, Nielsen, Karina, Spencer, Sandra E., Morin, Gregg B., Eaves, Connie J.

“…Mechanisms that regulate cell survival and proliferation are important for both the development and homeostasis of normal tissue, and as well as for the…”
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Characterization of a small molecule inhibitor of disulfide reductases that induces oxidative stress and lethality in lung cancer cells by Johnson, Fraser D., Ferrarone, John, Liu, Alvin, Brandstädter, Christina, Munuganti, Ravi, Farnsworth, Dylan A., Lu, Daniel, Luu, Jennifer, Sihota, Tianna, Jansen, Sophie, Nagelberg, Amy, Shi, Rocky, Forcina, Giovanni C., Zhang, Xu, Cheng, Grace S.W., Spencer Miko, Sandra E., de Rappard-Yuswack, Georgia, Sorensen, Poul H., Dixon, Scott J., Guha, Udayan, Becker, Katja, Djaballah, Hakim, Somwar, Romel, Varmus, Harold, Morin, Gregg B., Lockwood, William W.

“…Phenotype-based screening can identify small molecules that elicit a desired cellular response, but additional approaches are required to characterize their…”
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PeptideRanger: An R Package to Optimize Synthetic Peptide Selection for Mass Spectrometry Applications by Riley, Ryan M., Spencer Miko, Sandra E., Morin, Ryan D., Morin, Gregg B., Negri, Gian Luca

“…Targeted and semitargeted mass spectrometry-based approaches are reliable methods to consistently detect and quantify low abundance proteins including proteins…”
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Mass Spectrometry Acquisition and Fractionation Recommendations for TMT11 and TMT16 Labeled Samples by Riley, Ryan M., Negri, Gian Luca, Cheng, S.-W. Grace, Spencer Miko, Sandra E., Morin, Ryan D., Morin, Gregg B.

“…Proteome coverage and accurate protein quantification are both important for evaluating biological systems; however, compromises between quantification,…”
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Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma by Mooney, Brian, Negri, Gian Luca, Shyp, Taras, Delaidelli, Alberto, Zhang, Hai-Feng, Spencer Miko, Sandra E, Weiner, Amber K, Radaoui, Alexander B, Shraim, Rawan, Lizardo, Michael M, Hughes, Christopher S, Li, Amy, El-Naggar, Amal M, Rouleau, Melanie, Li, Wei, Dimitrov, Dimiter S, Kurmasheva, Raushan T, Houghton, Peter J, Diskin, Sharon J, Maris, John M, Morin, Gregg B, Sorensen, Poul H

“…Ewing sarcoma is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. Although the survival rate of patients…”
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The proteome of clear cell ovarian carcinoma by Ji, Jennifer X, Cochrane, Dawn R, Negri, Gian Luca, Colborne, Shane, Spencer Miko, Sandra E, Hoang, Lynn N, Farnell, David, Tessier‐Cloutier, Basile, Huvila, Jutta, Thompson, Emily, Leung, Samuel, Chiu, Derek, Chow, Christine, Ta, Monica, Köbel, Martin, Feil, Lucas, Anglesio, Michael, Goode, Ellen L, Bolton, Kelly, Morin, Gregg B, Huntsman, David G

“…Clear cell ovarian carcinoma (CCOC) is the second most common subtype of epithelial ovarian carcinoma. Late‐stage CCOC is not responsive to gold‐standard…”
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Metal Cationization Extractive Electrospray Ionization Mass Spectrometry of Compounds Containing Multiple Oxygens by Swanson, Kenneth D., Spencer, Sandra E., Glish, Gary L.

“…Extractive electrospray ionization is an ambient ionization technique that allows real-time sampling of liquid samples, including organic aerosols. Similar to…”
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A Framework for Quality Control in Quantitative Proteomics by Tsantilas, Kristine A., Merrihew, Gennifer E., Robbins, Julia E., Johnson, Richard S., Park, Jea, Plubell, Deanna L., Canterbury, Jesse D., Huang, Eric, Riffle, Michael, Sharma, Vagisha, MacLean, Brendan X., Eckels, Josh, Wu, Christine C., Bereman, Michael S., Spencer, Sandra E., Hoofnagle, Andrew N., MacCoss, Michael J.

“…A thorough evaluation of the quality, reproducibility, and variability of bottom-up proteomics data is necessary at every stage of a workflow, from planning to…”
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Phase Ib pharmacodynamic study of the MNK inhibitor Tomivosertib (eFT508) combined with paclitaxel in patients with refractory metastatic breast cancer by Ferrario, Cristiano, Mackey, John, Gelmon, Karen A., Levasseur, Nathalie, Sorensen, Poul H., Oo, Htoo Z., Negri, Gian L., Tse, Veronica W. L., Spencer, Sandra E., Cheng, Grace, Morin, Gregg B., del Rincon, Sonia, Cotechini, Tiziana, Gonçalves, Christophe, Hindmarch, Charles C.T., Miller, Wilson H., Amiri, Mehdi, Basiri, Tayebeh, Villareal-Corpuz, Victor, Sperry, Sam, Gregorczyk, Kevin, Spera, Gonzalo, Sonenberg, Nahum, Pollak, Michael

“…Purpose: Preclinical data motivate clinical evaluation of inhibitors of mitogen-activated protein kinase-interacting kinases 1 and 2 (MNK1/2). We conducted a…”
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Miniature Flow-Through Low-Temperature Plasma Ionization Source for Ambient Ionization of Gases and Aerosols by Spencer, Sandra E, Santiago, Brandon G, Glish, Gary L

“…The design and operation of an inexpensive, miniature low-temperature plasma ion source is detailed. The miniature low-temperature plasma ion source is…”
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Changes in the tumour microenvironment mark the transition from serous borderline tumour to low‐grade serous carcinoma by Vallejos, Rodrigo, Zhantuyakova, Almira, Negri, Gian Luca, Martin, Spencer D, Spencer, Sandra E, Thornton, Shelby, Leung, Samuel, Lynch, Branden, Qin, Yimei, Chow, Christine, Liang, Brooke, Zdravko, Sabrina, Douglas, J Maxwell, Milne, Katy, Mateyko, Bridget, Nelson, Brad H, Howitt, Brooke E, Kommoss, Felix KF, Horn, Lars‐Christian, Hoang, Lien, Singh, Naveena, Morin, Gregg B, Huntsman, David G, Cochrane, Dawn

“…Low‐grade serous ovarian carcinoma (LGSC) is a rare and lethal subtype of ovarian cancer. LGSC is pathologically, biologically, and clinically distinct from…”
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Low-Temperature Plasma Ionization-Mass Spectrometry for the Analysis of Compounds in Organic Aerosol Particles by Spencer, Sandra E, Tyler, Chelsea A, Tolocka, Michael P, Glish, Gary L

“…Low-temperature plasma ionization, a technique that causes minimal fragmentation during ionization, is investigated as an ionization technique for mass…”
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Automated Trapping Column Exchanger for High-Throughput Nanoflow Liquid Chromatography by Spencer, Sandra E, Corso, Thomas N, Bollinger, James G, Henderson, Clark M, Hoofnagle, Andrew N, MacCoss, Michael J

“…As compared to conventional high-performance liquid chromatography (HPLC) techniques, nanoflow HPLC exhibits improved sensitivity and limits of detection…”
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Matrix-assisted laser desorption/ionization–time of flight-mass spectrometry profiling of trace constituents of condom lubricants in the presence of biological fluids by Spencer, Sandra E, Kim, Sin Young, Kim, Seoung Bum, Schug, Kevin A

“…Abstract The use of condoms in sexual assault cases has become increasingly common due to the heightened awareness of the use of DNA as evidence in criminal…”
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Antimony(III)- D, L-Tartrates Exhibit Proton-Assisted Enantioselective Binding in Solution and in the Gas Phase by Wijeratne, Aruna B., Spencer, Sandra E., Gracia, Jose, Armstrong, Daniel W., Schug, Kevin A.

“…The negative ion mode ESI mass spectral analysis of antimony(III)-D- and - L-tartrate (“tartar emetic”), in association with leucine enantiomeric isotopomers,…”
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Hemolysis, Fish Mortality, and LC-ESI-MS of Cultured Crude and Fractionated Golden Alga (Prymnesium parvum) by Schug, Kevin A., Skingel, Theodore R., Spencer, Sandra E., Serrano, Carlos A., Le, Cuong Q., Schug, Christopher A., Valenti Jr, Theodore W., Brooks, Bryan W., Mydlarz, Laura D., Grover, James P.

“…Erythrocyte lysis and fish mortality assays, in combination with high performance liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS)…”
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Abstract PS18-06: Proteomic analysis of breast cancer formalin-fixed paraffin-embedded clinical specimens identifies biologically-important subtypes with distinct clinical outcomes by Asleh, Karama, Negri, Gian Luca, Miko, Sandra E. Spencer, Colborne, Shane, Hughes, Christopher S., Wang, Xiu Q., Gao, Dongxia, Gilks, C. Blake, Chia, Stephen K.L., Nielsen, Torsten O., Morin, Gregg B.

“…Background: Genomic classification of breast cancer has advanced breast cancer diagnosis and outcomes. However, extensive heterogeneity still exists beyond…”
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