Search Results - "Spencer, Richard D."

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions by Cole, Kevin P., Groh, Jennifer McClary, Johnson, Martin D., Burcham, Christopher L., Campbell, Bradley M., Diseroad, William D., Heller, Michael R., Howell, John R., Kallman, Neil J., Koenig, Thomas M., May, Scott A., Miller, Richard D., Mitchell, David, Myers, David P., Myers, Steven S., Phillips, Joseph L., Polster, Christopher S., White, Timothy D., Cashman, Jim, Hurley, Declan, Moylan, Robert, Sheehan, Paul, Spencer, Richard D., Desmond, Kenneth, Desmond, Paul, Gowran, Olivia

“…Advances in drug potency and tailored therapeutics are promoting pharmaceutical manufacturing to transition from a traditional batch paradigm to more flexible…”
Get full text

API Continuous Cooling and Antisolvent Crystallization for Kinetic Impurity Rejection in cGMP Manufacturing by Johnson, Martin D, Burcham, Christopher L, May, Scott A, Calvin, Joel R, McClary Groh, Jennifer, Myers, Steven S, Webster, Luke P, Roberts, Jeffrey C, Reddy, Venkata Ramana, Luciani, Carla V, Corrigan, Aoife P, Spencer, Richard D, Moylan, Robert, Boyse, Raymond, Murphy, John D, Stout, James R

“…Crystallization of 204 kg of final active pharmaceutical ingredient was accomplished continuously using a cascade of mixed suspension mixed product removal…”
Get full text

Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing by Frederick, Michael O, Boyse, Raymond A, Braden, Timothy M, Calvin, Joel R, Campbell, Bradley M, Changi, Shujauddin M, Coffin, Stephanie R, Condon, Carmel, Gowran, Olivia, McClary Groh, Jennifer, Groskreutz, Stephen R, Harms, Zachary D, Humenik, Ashley A, Kallman, Neil J, Klitzing, Nicholas D, Kopach, Michael E, Kretsinger, Juliana K, Lambertus, Gordon R, Lampert, Jeffrey T, Maguire, Laura M, Moynihan, Humphrey A, Mullane, Nessa S, Murphy, John D, O’Mahony, Marie E, Richey, Rachel N, Seibert, Kevin D, Spencer, Richard D, Strege, Mark A, Tandogan, Nil, Torres Torres, Frank L, Tsukanov, Sergey V, Xia, Han

“…The large-scale manufacture of complex synthetic peptides is challenging due to many factors such as manufacturing risk (including failed product…”
Get full text

Development and Manufacturing GMP Scale-Up of a Continuous Ir-Catalyzed Homogeneous Reductive Amination Reaction by May, Scott A, Johnson, Martin D, Buser, Jonas Y, Campbell, Alison N, Frank, Scott A, Haeberle, Brian D, Hoffman, Philip C, Lambertus, Gordon R, McFarland, Adam D, Moher, Eric D, White, Timothy D, Hurley, D. Declan, Corrigan, Aoife P, Gowran, Olivia, Kerrigan, Niall G, Kissane, Marie G, Lynch, Regina R, Sheehan, Paul, Spencer, Richard D, Pulley, Shon R, Stout, James R

“…The design, development, and scale up of a continuous iridium-catalyzed homogeneous high pressure reductive amination reaction to produce 6, the penultimate…”
Get full text

Development of a Commercial Flow Barbier Process for a Pharmaceutical Intermediate by Braden, Timothy M, Johnson, Martin D, Kopach, Michael E, McClary Groh, Jennifer, Spencer, Richard D, Lewis, Jeffrey, Heller, Michael R, Schafer, John P, Adler, Jonathan J

“…A flow Barbier process was developed to produce a key intermediate in the edivoxetine·HCl registered sequence. The control strategy was developed based on a…”
Get full text

Development of Universal, Automated Sample Acquisition, Preparation, and Delivery Devices and Methods for Pharmaceutical Applications by Lambertus, Gordon R, Webster, Luke P, Braden, Timothy M, Campbell, Bradley M, McClary Groh, Jennifer, Maloney, Todd D, Milenbaugh, Paul, Spencer, Richard D, Sun, Wei-ming, Johnson, Martin D

“…Continued emphasis in the pharmaceutical industry toward development of hybrid and continuous processes has led to a resurgence in process analytical…”
Get full text

Operation Strategy Development for Grignard Reaction in a Continuous Stirred Tank Reactor by Wong, Sze-Wing, Changi, Shujauddin M, Shields, Richard, Bell, Willis, McGarvey, Bernard, Johnson, Martin D, Sun, Wei-Ming, Braden, Tim M, Kopach, Michael E, Spencer, Richard D, Flanagan, Gordon, Murray, Michael

“…This paper presents a case study in establishing the operation space of a Grignard reaction in a continuous stirred tank reactor (CSTR). The operation space is…”
Get full text

Continuous GMP Manufacturing for Grignard Reagent/Zincate Synthesis and Negishi Coupling Reaction by Calvin, Joel R., Boyse, Raymond, Braden, Timothy M., Brewer, Alison C., Changi, Shujauddin, Harrold, Donal, Johnson, Martin, Kerr, Mark S., Lambertus, Gordon R., Luciani, Carla V., May, Scott A., Moloney, Harold, Murphy, John D., Roberts, Jeffrey C., Schafer, John P., Spencer, Richard D., Webster, Luke P.

“…A synthetic route to API was designed containing a Negishi cross-coupling reaction, where the zincate reagent was generated by transmetalation of a Grignard…”
Get full text

Synthetic spectroscopic models related to coenzymes and base pairs. V. Emission properties of NADH. Studies of fluorescence lifetimes and quantum efficiencies of NADH, AcPyADH, [reduced acetylpyridineadenine dinucleotide] and simplified synthetic models by Scott, T. Gordon, Spencer, Richard D, Leonard, Nelson J, Weber, Gregorio

Get full text

Globulin-specific proteolytic activity in germinating pumpkin seeds as detected by a fluorescence assay method by Spencer, P W, Spencer, R D

“…The proteolytic activities of α-chymotrypsin, trypsin, pepsin, bromelain, and an extract from germinating pumpkin seeds (Cucurbita moschata) were determined by…”
Get full text

Flavin 1, N6-ethenoadenine Dinucleotide: Dynamic and Static Quenching of Fluorescence by Barrio, Jorge R., Tolman, Glen L., Leonard, Nelson J., Spencer, Richard D., Weber, Gregorio

“…Flavin 1,N6-ethenoadenine dinucleotide (ε FAD) was prepared by the action of chloroacetaldehyde on flavin adenine dinucleotide. This compound, which has two…”
Get full text

A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarction by Povsic, Thomas J., MD, PhD, FACC, O'Connor, Christopher M., MD, FACC, Henry, Timothy, MD, FACC, Taussig, Andrew, MD, FACC, Kereiakes, Dean J., MD, FACC, Fortuin, F. David, MD, FACC, Niederman, Alan, MD, FACC, Schatz, Richard, MD, FACC, Spencer, Richard, JD, Owens, Douglas, RN, Banks, Missy, BA, Joseph, Diane, BS, Roberts, Rhonda, MSPH, Alexander, John H., MD, MHS, FACC, Sherman, Warren, MD, FACC

“…Background We sought to determine the safety and preliminary efficacy of transcatheter intramyocardial administration of myoblasts in patients with heart…”
Get full text

Species Responsible for the Fluorescence of 1: N6‐Ethenoadenosine by Spencer, Richard D., Weber, Gregorio, Tolman, Glen L., Leonard, Nelson J., Barrio, Jorge R.

“…1 Fluorescence lifetimes and emission spectra of 1: N6‐ethenoadenosine 5′‐monophosphate (ɛAMP) in aqueous solution over the pH range 1.5 to 12.0 indicate the…”
Get full text

Fluorescence polarization: measurements with a photon-counting photometer by Jameson, D M, Weber, G, Spencer, R D, Mitchell, G

“…A T-format, photon-counting polarization photometer was constructed to facilitate precise polarization measurements at low signal-to-noise ratios. The…”
Get more information

Globulin-specific Proteolytic Activity in Germinating Pumpkin Seeds as Detected by a Fluorescence Assay Method 1 by Spencer, Patricia W., Spencer, Richard D.

“…The proteolytic activities of α-chymotrypsin, trypsin, pepsin, bromelain, and an extract from germinating pumpkin seeds ( Cucurbita moschata ) were determined…”
Get full text

Design, construction, and two applications for an automated flow-cell polarization fluorometer with digital read out: enzyme-inhibitor (antitrypsin) assay and antigen-antibody (insulin-insulin antiserum) assay by Spencer, R D, Toledo, F B, Williams, B T, Yoss, N L

Get more information

Flavin 1, N 6 -ethenoadenine dinucleotide: dynamic and static quenching of fluorescence by Barrio, J R, Tolman, G L, Leonard, N J, Spencer, R D, Weber, G

“…Flavin 1,N(6)-ethenoadenine dinucleotide (epsilonFAD) was prepared by the action of chloroacetaldehyde on flavin adenine dinucleotide. This compound, which has…”
Get full text

Direct fluorimetric assay for proteolytic activity against intact proteins by Spencer, P W, Titus, J S, Spencer, R D

Get more information