Search Results - "Spencer, Nick J"

The Diverse Metabolic Roles of Peripheral Serotonin by Martin, Alyce M., Young, Richard L., Leong, Lex, Rogers, Geraint B., Spencer, Nick J., Jessup, Claire F., Keating, Damien J.

“…Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with important signaling roles in a range of physiological pathways. Almost all…”
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Identification of different types of spinal afferent nerve endings that encode noxious and innocuous stimuli in the large intestine using a novel anterograde tracing technique by Spencer, Nick J, Kyloh, Melinda, Duffield, Michael

“…In mammals, sensory stimuli in visceral organs, including those that underlie pain perception, are detected by spinal afferent neurons, whose cell bodies lie…”
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Optogenetic Induction of Colonic Motility in Mice by Hibberd, Timothy J., Feng, Jing, Luo, Jialie, Yang, Pu, Samineni, Vijay K., Gereau, Robert W., Kelley, Nigel, Hu, Hongzhen, Spencer, Nick J.

“…Strategies are needed to increase gastrointestinal transit without systemic pharmacologic agents. We investigated whether optogenetics, focal application of…”
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The role of enteric inhibitory neurons in intestinal motility by Costa, Marcello, Spencer, Nick J., Brookes, Simon J.H.

“…The enteric nervous system controls much of the mixing and propulsion of nutrients along the digestive tract. Enteric neural circuits involve intrinsic sensory…”
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First translational consensus on terminology and definitions of colonic motility in animals and humans studied by manometric and other techniques by Corsetti, Maura, Costa, Marcello, Bassotti, Gabrio, Bharucha, Adil E., Borrelli, Osvaldo, Dinning, Phil, Di Lorenzo, Carlo, Huizinga, Jan D., Jimenez, Marcel, Rao, Satish, Spiller, Robin, Spencer, Nick J., Lentle, Roger, Pannemans, Jasper, Thys, Alexander, Benninga, Marc, Tack, Jan

“…Alterations in colonic motility are implicated in the pathophysiology of bowel disorders, but high-resolution manometry of human colonic motor function has…”
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Postoperative ileus—An ongoing conundrum by Wattchow, David, Heitmann, Paul, Smolilo, David, Spencer, Nick J., Parker, Dominic, Hibberd, Timothy, Brookes, Simon S. J., Dinning, Phil G., Costa, Marcello

“…Background Postoperative ileus is common and is a major clinical problem. It has been widely studied in patients and in experimental models in laboratory…”
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Translating peripheral bladder afferent mechanosensitivity to neuronal activation within the lumbosacral spinal cord of mice by Grundy, Luke, Harrington, Andrea M., Caldwell, Ashlee, Castro, Joel, Staikopoulos, Vasiliki, Zagorodnyuk, Vladimir P., Brookes, Simon J.H., Spencer, Nick J., Brierley, Stuart M.

“…Primary afferent neurons transduce distension of the bladder wall into action potentials that are relayed into the spinal cord and brain, where autonomic…”
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Tetrodotoxin‐resistant mechanosensitivity and L‐type calcium channel‐mediated spontaneous calcium activity in enteric neurons by Amedzrovi Agbesi, Richard J., El Merhie, Amira, Spencer, Nick J., Hibberd, Tim, Chevalier, Nicolas R.

“…Gut motility undergoes a switch from myogenic to neurogenic control in late embryonic development. Here, we report on the electrical events that underlie this…”
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How should we define a nociceptor in the gut-brain axis? by Spencer, Nick J, Hibberd, Tim, Xie, Zili, Hu, Hongzhen

“…In the past few years, there has been extraordinary interest in how the gut communicates with the brain. This is because substantial and gathering data has…”
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Visceral pain – Novel approaches for optogenetic control of spinal afferents by Spencer, Nick J., Hibberd, Tim J., Lagerström, Malin, Otsuka, Yoichiro, Kelley, Nigel

“…[Display omitted] •Anterograde tracing can be reliably performed from dorsal root ganglia (DRG).•Channelrhodopsin or Archaerhodopsin can now be selectively…”
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Identifying unique subtypes of spinal afferent nerve endings within the urinary bladder of mice by Spencer, Nick J., Greenheigh, Sarah, Kyloh, Melinda, Hibberd, Tim J., Sharma, Harman, Grundy, Luke, Brierley, Stuart M., Harrington, Andrea M., Beckett, Elizabeth A., Brookes, Simon J., Zagorodnyuk, Vladimir P.

“…Spinal afferent neurons are responsible for the transduction and transmission of noxious (painful) stimuli and innocuous stimuli that do not reach conscious…”
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Novel insights into mechanisms of inhibition of colonic motility by loperamide by Parkar, Nabil, Spencer, Nick J, Wiklendt, Luke, Olson, Trent, Young, Wayne, Janssen, Patrick, McNabb, Warren C, Dalziel, Julie E

“…It is well known that opiates slow gastrointestinal (GI) transit, via suppression of enteric cholinergic neurotransmission throughout the GI tract,…”
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Circadian rhythms in colonic function by Hibberd, Timothy J, Ramsay, Stewart, Spencer-Merris, Phaedra, Dinning, Phil G, Zagorodnyuk, Vladimir P, Spencer, Nick J

“…A rhythmic expression of clock genes occurs within the cells of multiple organs and tissues throughout the body, termed "peripheral clocks." Peripheral clocks…”
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Roles of three distinct neurogenic motor patterns during pellet propulsion in guinea‐pig distal colon by Costa, Marcello, Keightley, Lauren J., Wiklendt, Lukasz, Hibberd, Timothy J., Arkwright, John W., Omari, Taher, Wattchow, David A., Zagorodnyuk, Vladimir, Brookes, Simon J. H., Dinning, Phil G., Spencer, Nick J.

“…Key points Enteric neural circuits enable isolated preparations of guinea‐pig distal colon to propel solid and fluid contents by a self‐sustaining…”
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Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model by Parkar, Nabil, Dalziel, Julie E, Spencer, Nick J, Janssen, Patrick, McNabb, Warren C, Young, Wayne

“…Gastrointestinal (GI) motility is largely dependent upon activity within the enteric nervous system (ENS) and is an important part of the digestive process…”
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Modification of Neurogenic Colonic Motor Behaviours by Chemogenetic Ablation of Calretinin Neurons by Feng, Jing, Hibberd, Tim J, Luo, Jialie, Yang, Pu, Xie, Zili, Travis, Lee, Spencer, Nick J, Hu, Hongzhen

“…How the enteric nervous system determines the pacing and propagation direction of neurogenic contractions along the colon remains largely unknown. We used a…”
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Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry by Chen, Bao Nan, Humenick, Adam G, Hibberd, Timothy James, Yew, Wai Ping, Wattchow, David A, Dinning, Phil G, Costa, Marcello, Spencer, Nick J, Brookes, Simon J H

“…Viscerofugal neurons (VFNs) have cell bodies in the myenteric plexus and axons that project to sympathetic prevertebral ganglia. In animals they activate…”
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Prevalence of childhood disability and the characteristics and circumstances of disabled children in the UK: secondary analysis of the Family Resources Survey by Blackburn, Clare M, Spencer, Nick J, Read, Janet M

“…Robust data on the prevalence of childhood disability and the circumstances and characteristics of disabled children is crucial to understanding the…”
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Characterization of projections of longitudinal muscle motor neurons in human colon by Humenick, Adam, Chen, Bao Nan, Lauder, Chris I. W., Wattchow, David A., Zagorodnyuk, Vladimir P., Dinning, Phil G., Spencer, Nick J., Costa, Marcello, Brookes, Simon J. H.

“…Background The enteric nervous system contains inhibitory and excitatory motor neurons which modulate smooth muscle contractility. Cell bodies of longitudinal…”
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Anatomical distribution of CGRP-containing lumbosacral spinal afferent neurons in the mouse uterine horn by Dodds, Kelsi N., Kyloh, Melinda A., Travis, Lee, Cox, Mack, Hibberd, Tim J., Spencer, Nick J.

“…Sensory stimuli from the uterus are detected by spinal afferent neurons whose cell bodies arise from thoracolumbar and lumbosacral dorsal root ganglia (DRG)…”
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